Surface Engineered Biomaterials to Control Inflammation. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedica ....Surface Engineered Biomaterials to Control Inflammation. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation and subsequent foreign body reaction (FBR) medical implants and tissue engineering constructs.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
Substrate-integrated wearable antennas for unobtrusive activity monitoring. This project aims to develop a novel class of wearable textile antennas that can form robust connections with miniature battery-less motion sensors for non-invasive activity monitoring of older people. In contrast to bulky body worn sensors that must be strapped on, it is anticipated that the garment-integrated textile antennas patterned through computerised embroidery will lead to low-cost, low-profile, and flexible ant ....Substrate-integrated wearable antennas for unobtrusive activity monitoring. This project aims to develop a novel class of wearable textile antennas that can form robust connections with miniature battery-less motion sensors for non-invasive activity monitoring of older people. In contrast to bulky body worn sensors that must be strapped on, it is anticipated that the garment-integrated textile antennas patterned through computerised embroidery will lead to low-cost, low-profile, and flexible antennas that are truly wearable with exceptional performance and scalable manufacturing techniques. The outcomes from the project are expected to underpin innovative applications, such as aged care, providing a means for caregivers to automatically monitor health and physical activity and intervene as required. Such applications would support ageing Australians to live with greater independence and safety.Read moreRead less
A nanoengineered solution to drug delivery in bone. This project presents an exciting new approach of applying nanotechnology to bone research. By combining our expertise in nanoengineering of new materials, mathematical modelling and bone biology, this project will result in a well-characterised model for drug delivery into bone and lead to a new therapeutic approach for treating bone diseases.
Dynamic terahertz superlenses for sub-wavelength sensing and imaging. We propose to develop a 'dynamic terahertz superlens' that will dramatically enhance the performance of existing T-ray imaging systems used for biosensing of cells, DNA and proteins. The science of the superlens is remarkable in that it enables image resolution shorter than the wavelength.
Unified framework of intestinal motility. The project aims to establish how a few fundamental mechanisms determine the large repertoire of intestinal motor patterns responsible for moving nutrients along the digestive tract. The project will combine experimental and theoretical data, with biomechanical and electrophysiological models to create a new understanding of this essential function of the body.
Functional characterisation of poly-histidine triad proteins. This project aims to understand the role and function of a novel family of surface proteins produced by Streptococci. These so-called polyhistidine triad proteins are known to contribute to capacity to cause disease in animals and humans, but we need to know how they work, as they may be excellent targets for novel drugs or vaccines.
Novel perspectives on the function of AB5 toxin B subunits in pathogenic bacterial. AB5 toxins are produced by bacteria that cause important diseases in humans and livestock. This project tests the hypothesis that the components of the toxins responsible for binding to host cells and tissues also directly contribute to cellular damage, thereby providing a better understanding of how AB5 toxin-producing bacteria cause disease.
Numerical simulation of seismic waves in the regional and global earth with 3D Gaussian quadrature grids. The ability to realistically model the propagation of seismic waves through the global 3D earth, taking account of all internal and surface complexity, is extremely important for predicting the response to earthquakes and imaging the interior structure. This will lead to fundamental new knowledge on Earth constitution and heterogeneity, and will have spin-off benefits in others areas such as ....Numerical simulation of seismic waves in the regional and global earth with 3D Gaussian quadrature grids. The ability to realistically model the propagation of seismic waves through the global 3D earth, taking account of all internal and surface complexity, is extremely important for predicting the response to earthquakes and imaging the interior structure. This will lead to fundamental new knowledge on Earth constitution and heterogeneity, and will have spin-off benefits in others areas such as exploring for oil and minerals, and better understanding of seismic hazard. The numerical modelling and seismic data analysis will be done on a supercomputer, thus providing important training for research students. Read moreRead less
Bacterial poly-histidine triad proteins. The poly-histidine triad (Pht) proteins are a poorly characterised family of surface proteins expressed by the genus Streptococcus and other Gram-positive genera. Recent studies suggest an important role for Pht proteins in survival of these bacteria in low zinc (Zn) environments. The project hypothesis is that Pht proteins specifically recruit Zn from the extracellular environment and somehow make it available to ATP binding cassette (ABC) transport syst ....Bacterial poly-histidine triad proteins. The poly-histidine triad (Pht) proteins are a poorly characterised family of surface proteins expressed by the genus Streptococcus and other Gram-positive genera. Recent studies suggest an important role for Pht proteins in survival of these bacteria in low zinc (Zn) environments. The project hypothesis is that Pht proteins specifically recruit Zn from the extracellular environment and somehow make it available to ATP binding cassette (ABC) transport systems located in the bacterial plasma membrane, beneath the cell wall, facilitating Zn uptake by the bacterium. The aim of this project is to conduct comprehensive molecular characterization of the interactions between Pht proteins, Zn and ABC transporters, and the role of the histidine triad motifs in these interactions.Read moreRead less