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The Associations Between Cognitive Decline And Genetic Polymorphisms, Hormones And Cardiovascular Risk Factors In Women.
Funder
National Health and Medical Research Council
Funding Amount
$358,079.00
Summary
Dementia, a major cause of morbidity and mortality in ageing women, has been linked to hormonal changes and genes. If factors associated with impaired cognition and early Alzheimer's disease could be identified then early interventions could be offered to those at risk. In this study we determine the genetic, medical and lifestyle factors which may be associated with cognitive decline and early Alzheimer's disease in women from pre-menopause into their post-menopausal years.
Melanomas are common cancers arising from the pigment cells of the skin. Sunlight is the principal environmental causal factor for this group of cancers, although there is increasing evidence that the effect of sunlight on the pigment cells is not the same for all people. We aim to answer the question. Does host phenotype predict the response of melanocytes to sunlight and in so doing, contribute information that may assist the development of effective prevention strategies
Epigenetic Hyperglycemic Cell Memory Causes Vascular Complications In Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$332,140.00
Summary
This project seeks to identify how epigenetic change in response to hyperglycemia can cause vascular complications of diabetes, and how this contributes to “hyperglycemic memory”; a phenomena where cells may undergo gene modifications which increase risk to further complications later in a patients life. These studies are the first of their kind and will characterize the types of epigenetic change that can cause human disease.
Cellular And Molecular Determinants That Regulate Osteoblasts At The Endosteal Niche During HSC Mobilisation
Funder
National Health and Medical Research Council
Funding Amount
$178,523.00
Summary
Treatments for leukaemia (e.g. chemotherapy) severely deplete immune and blood cells from patients. Transplantation of new blood forming cells (blood stem cells) into these patients is essential, but challenges are faced with isolating sufficient numbers in ways that preserve their ability to reconstitute the blood post transplant. My research aims to advance understanding of current methods used to isolate these cells and ultimately to improve the success of blood stem cell transplantation.
Defining Treatment Targets To Optimise The Management Of Early Midfoot Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Midfoot osteoarthritis (OA) is a common cause of foot pain and responsible for significant pain and disability. This project will investigate the early structural and functional changes in the midfoot joints and determine the relationships between foot joint loading, structural changes, symptoms and functional impairment. This will identify modifiable factors involved in midfoot OA and define treatment targets to inform the development of effective interventions.
High-risk Doctors: Early Identification And Intervention To Protect Patients From Harm
Funder
National Health and Medical Research Council
Funding Amount
$224,786.00
Summary
When a doctor's health or performance falters, patient safety may be placed at risk. Previous research tells us that some doctors are at higher risk of running into difficulty than others. Regulators, like the Medical Board, collect masses of information, but this information is rarely used to try and identify and intervene early BEFORE harm occurs. Our research seeks to change this by identifying which doctors are at greatest risk and why, and how they can be supported back into safe practice.