Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100175
Funder
Australian Research Council
Funding Amount
$347,070.00
Summary
Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used ....Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used to produce structures wherein living cells are spatially organised in combination with appropriate biomaterials and bioactive components, such as drugs or growth factors, in order to influence subsequent biological behaviour.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100026
Funder
Australian Research Council
Funding Amount
$3,722,989.00
Summary
ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative m ....ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative medicine; and additive manufactured tools for surgical planning and education. Highly experienced researchers and industry partners with teams of exceptional post-doctoral fellows and doctoral students would drive each technology. Anticipated impacts are that Australia will be a world-leader in additive biomanufacturing, and that the research will change the fields of science, health and biotechnology.Read moreRead less
Future neural electrodes: probing the electrical activity of nerves using 3D graphene networks. This research aims to develop a totally new type of neural electrode that will for the first time, allow reliable and long-term stimulation and recording. The approach incorporates graphene based biomaterials with tunable electrical and biological properties within supportive three-dimensional cellular microenvironments, greatly enhancing the electrical interactions between cells and the electrode. Th ....Future neural electrodes: probing the electrical activity of nerves using 3D graphene networks. This research aims to develop a totally new type of neural electrode that will for the first time, allow reliable and long-term stimulation and recording. The approach incorporates graphene based biomaterials with tunable electrical and biological properties within supportive three-dimensional cellular microenvironments, greatly enhancing the electrical interactions between cells and the electrode. The electrical properties of nerve cells will be probed using our three-dimensional graphene network, providing insight into the the brain-machine interface. This project is important as it directly addresses the inherent limitations of current electrode designs.Read moreRead less
Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these in ....Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these investigations a new biomimetic analogue of the perilymph (cochlea fluid) is intended to be developed. Additionally, the project aims to investigate two strategies to minimise impedance changes: small pulse electrode cleaning and antifouling coatings. Understanding and control of factors influencing electrode stability aim to facilitate next-generation implant designs.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100024
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, internatio ....ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, international collaborations and a generation of industry-ready researchers critical for growing Australia’s industry. The advances in materials and savings in time for procedures will reduce costs.
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Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Novel antimicrobial surface coatings for biomedical applications. There are currently no effective biomaterial coatings to reduce device related infections. Such materials are needed to address the high rates of infection that can occur. The melimine technology proposed here has the potential to significantly reduce rates of infection, reduce health care costs and advantage the Australian biomaterials industry.
A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boo ....A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boost skin healing rate. This knowledge may ultimately be used to develop wound dressings that maximise healing rate for various skin defects such as chronic wounds and decrease health care costs.Read moreRead less
Novel Antimicrobial Biomaterials. There is a clear need for new materials that repel bacteria. Infections associated with biomaterials incur a high cost in terms of human health and well being, but such infections also increase the burden on the health care system by extending hospital stays and significantly elevating costs. The cost of a catheter-related blood stream infection is around $50,000 for patients in intensive care units. If all medical devices are considered, the cost of related inf ....Novel Antimicrobial Biomaterials. There is a clear need for new materials that repel bacteria. Infections associated with biomaterials incur a high cost in terms of human health and well being, but such infections also increase the burden on the health care system by extending hospital stays and significantly elevating costs. The cost of a catheter-related blood stream infection is around $50,000 for patients in intensive care units. If all medical devices are considered, the cost of related infections is then approximately $20 billion. The technology proposed here has the potential to reduce biomaterial related infection rates, improve health care and reduce health care costs. Read moreRead less