Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer t ....Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer tissue state and morphology indirectly based on phase delay, speckle, and angle-resolved scattering. We will break new ground in correlating the structure and function of in situ epithelial tissue and cells to light scattering enabling, e.g., the detection of mitosis and apoptosis in cells buried in thick, turbid media, and of cancers and precancers in vivo.Read moreRead less
Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currentl ....Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currently not possible. We also plan to make advances in the key area of scanning delay line technology by employing acousto-optics in OCT for the first time. Acousto-optics conveys advantages in no-moving-parts, scan-speed and accuracy.Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Quantum and Geometric Aspects of Gauge Theories, Supergravity and String Theory. A central problem of modern high-energy physics is the unification of gravity with the other fundamental interactions that is consistent at the quantum level. Led by a team of internationally recognized experts, this project will yield breakthroughs in supergravity and string theory - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, ....Quantum and Geometric Aspects of Gauge Theories, Supergravity and String Theory. A central problem of modern high-energy physics is the unification of gravity with the other fundamental interactions that is consistent at the quantum level. Led by a team of internationally recognized experts, this project will yield breakthroughs in supergravity and string theory - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, a fertile environment will be provided for the training of graduate students. They will be ideally placed to lead Australia's involvement in the revolution sparked by the expected experimental confirmation of supersymmetry with the Large Hadron Collider. Read moreRead less
Progress in Supersymmetry and Supergravity: Continuing Einstein's Legacy. 2005 is the International Year of Physics in recognition of Einstein's revolutionary contributions. His unfinished quest for a unified description of Nature has become the hottest topic in modern physics. Led by a team of internationally recognized experts, this project will yield breakthroughs in supersymmetry and supergravity - crucial ingredients of current approaches to unification. As well as putting Australia at the ....Progress in Supersymmetry and Supergravity: Continuing Einstein's Legacy. 2005 is the International Year of Physics in recognition of Einstein's revolutionary contributions. His unfinished quest for a unified description of Nature has become the hottest topic in modern physics. Led by a team of internationally recognized experts, this project will yield breakthroughs in supersymmetry and supergravity - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, a fertile environment will be provided for the training of graduate students. They will be ideally placed to lead Australia's involvement in the revolution sparked by the expected experimental confirmation of supersymmetry with the next generation of particle accelerators.Read moreRead less
Low Energy Effective Actions in Supersymmetric Gauge Theories. The quest for a unified quantum theory of all the fundamental interactions of Nature, including gravity, is a major goal of modern physics. Superstring theory is at present the only plausible candidate. This theory makes nontrivial predictions (non-renormalization theorems) about the low energy structure of certain supersymmetric gauge theories (the Standard Model of particle physics is a special gauge theory). This project will deve ....Low Energy Effective Actions in Supersymmetric Gauge Theories. The quest for a unified quantum theory of all the fundamental interactions of Nature, including gravity, is a major goal of modern physics. Superstring theory is at present the only plausible candidate. This theory makes nontrivial predictions (non-renormalization theorems) about the low energy structure of certain supersymmetric gauge theories (the Standard Model of particle physics is a special gauge theory). This project will develop new tools for the computation of low energy effective actions, which will then be used for a detailed analysis of the non-renormalization theorems governing the low energy dynamics of supersymmetric gauge theories. This research is at the forefront of modern particle physics.Read moreRead less
Atomic Ionization on the Attosecond Time Scale. Electrons emit light, carry electric current, and bind atoms together to form molecules. Insight into their atomic-scale motion is the key to understanding the functioning of biological systems, developing efficient sources of x-ray light, and speeding up electronics. Capturing this electron motion requires attosecond (one quintillionth of a second) time resolution. Our research aims to understand and accurately model fundamental atomic processes ....Atomic Ionization on the Attosecond Time Scale. Electrons emit light, carry electric current, and bind atoms together to form molecules. Insight into their atomic-scale motion is the key to understanding the functioning of biological systems, developing efficient sources of x-ray light, and speeding up electronics. Capturing this electron motion requires attosecond (one quintillionth of a second) time resolution. Our research aims to understand and accurately model fundamental atomic processes taking place on the attosecond time scale. This research project will further enhance our reputation in an area where Australian theorists are preeminent, and the research training will produce PhD graduates with the skills essential in a multitude of nano-technology applications. Read moreRead less
Spin-dependent interactions: a fundamental basis for spin-electronics. This project will establish a comprehensive understanding of spin-dependent interactions and correlated behaviour of multi-electron systems that are responsible for spin-relaxation, spin transport and spin coherence in spin-electronic devices. Our approach is based on the spin-resolved two-electron coincidence spectroscopy that is inherently suited for studying electronic correlations. Systematic investigations of spin-depend ....Spin-dependent interactions: a fundamental basis for spin-electronics. This project will establish a comprehensive understanding of spin-dependent interactions and correlated behaviour of multi-electron systems that are responsible for spin-relaxation, spin transport and spin coherence in spin-electronic devices. Our approach is based on the spin-resolved two-electron coincidence spectroscopy that is inherently suited for studying electronic correlations. Systematic investigations of spin-dependent interactions in atoms, molecules and ultrathin films will increase understanding of magnetic (spin) properties of artificially structured materials with reduced dimensionality for the benefit of nanotechnology. This understanding will be used to design and control, at the quantum mechanical level, the building blocks of spin-electronic devices.Read moreRead less
Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understandi ....Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understanding of cells, the building blocks of life. We will achieve this by: 1. Developing a microscope that combines microscopic resolution with rapid imaging; 2: Developing the capability to image both within the cell and its surrounding environment; and 3. Using our microscope to make discoveries in biology.Read moreRead less