Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to b ....Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to build a laser device that incorporates a deformable mirror to investigate the interplay between aberrations and visual clarity. This new knowledge is a vital next step to improve laser eye-surgery success.Read moreRead less
Studying cell mechanics with a biophotonics-based tool. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise ....Studying cell mechanics with a biophotonics-based tool. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise conditioning protocols, thereby improving the properties of engineered tissue.
During this study we will develop optical tools that have applications in the life sciences, in the development of advanced materials and in nanotechnology. Our project will promote Australian research in these fields.Read moreRead less
Spectroscopy of complex and biological micro-objects for biosensing applications. The optically based test for specific DNA binding resulting from the conclusion of this project is of great potential benefit to all Australians as DNA is the building block of all living organisms. The technique developed and resulting biosensor will provide an invaluable tool for the determination and analysis of specific DNA reactions. The general technique developed for the genetic targeting of specific DNA rea ....Spectroscopy of complex and biological micro-objects for biosensing applications. The optically based test for specific DNA binding resulting from the conclusion of this project is of great potential benefit to all Australians as DNA is the building block of all living organisms. The technique developed and resulting biosensor will provide an invaluable tool for the determination and analysis of specific DNA reactions. The general technique developed for the genetic targeting of specific DNA reactions makes the detection of diseases and toxins like Chlamydia and anthrax, for example cheap, quick and accurate, keeping Australian's healthy, and strengthening national security.Read moreRead less
Joint Theoretical and Experimental Electron Momentum Spectroscopic Studies for DNA Bases. The study of DNA structure is an area of intense research activity and continues to reveal new levels of complexity and diversity. Recent experiments (Science, 2002) provided direct evidences of the adenine non-planarity, indicating non-rigidity of DNA bases. Electron momentum spectroscopy (EMS) has been identified to be an appropriate technique in the study of chemical binding mechanism and orbitals at mol ....Joint Theoretical and Experimental Electron Momentum Spectroscopic Studies for DNA Bases. The study of DNA structure is an area of intense research activity and continues to reveal new levels of complexity and diversity. Recent experiments (Science, 2002) provided direct evidences of the adenine non-planarity, indicating non-rigidity of DNA bases. Electron momentum spectroscopy (EMS) has been identified to be an appropriate technique in the study of chemical binding mechanism and orbitals at molecular level. The aims of the project is to study orbitals and interactions of DNA and RNA bases such as adenine, thymine (uracil), guanine and cytosine using momentum space quantum mechanics and EMS experimental techniques. The outcome of the project will improve our understanding of the DNA double helical strand structure.Read moreRead less
Implementing large-scale solid-state quantum computation. The goal of quantum computing research is to harness the properties of quantum mechanics to build computers that are exponentially more powerful than the computers of today. Along the way, many spin-off technologies for conventional computing and nanotechnology are expected. Realising the quantum computing dream is a daunting experimental challenge requiring both theoretical assurance that it is possible in principle, and theoretical guid ....Implementing large-scale solid-state quantum computation. The goal of quantum computing research is to harness the properties of quantum mechanics to build computers that are exponentially more powerful than the computers of today. Along the way, many spin-off technologies for conventional computing and nanotechnology are expected. Realising the quantum computing dream is a daunting experimental challenge requiring both theoretical assurance that it is possible in principle, and theoretical guidance as to the best method. We seek to provide this theoretical support for solid-state systems, and broaden the range of problems that such systems are demonstrably suited to tackle.Read moreRead less
Atom Location by Channelling Enhanced Microanalysis using Inner-shell Electron Energy Loss Spectroscopy. The technique of Atom Location by Channelling Enhanced Microanalysis (ALCHEMI) has been explored extensively using Electron Energy Dispersive X-ray (EDX) measurements by many authors. The extension of this method to Electron Energy Loss Spectroscopy (EELS) is difficult due to the more complicated formulation of inner-shell ionization required under such experimental conditions. Issues such ....Atom Location by Channelling Enhanced Microanalysis using Inner-shell Electron Energy Loss Spectroscopy. The technique of Atom Location by Channelling Enhanced Microanalysis (ALCHEMI) has been explored extensively using Electron Energy Dispersive X-ray (EDX) measurements by many authors. The extension of this method to Electron Energy Loss Spectroscopy (EELS) is difficult due to the more complicated formulation of inner-shell ionization required under such experimental conditions. Issues such as the "delocalization" of the ionization interaction and the significance of channelling of the scattered electron need to be addressed so that this method may be generally applicable. It is the aim of this project to extend this commonly used method to the topical field of EELS.Read moreRead less
The phase and inverse scattering problem for electrons multiply scattered by non-periodic solids. Theoretical methods for the inversion of multiple scattering of electrons in non-periodic solids will be obtained. This will vastly extend the range of utility of atomic resolution electron microscopy and electron tomography, where single scattering conditions are usually assumed. We will further develop our recent novel solutions to the phase problem from images and diffraction patterns (needed as ....The phase and inverse scattering problem for electrons multiply scattered by non-periodic solids. Theoretical methods for the inversion of multiple scattering of electrons in non-periodic solids will be obtained. This will vastly extend the range of utility of atomic resolution electron microscopy and electron tomography, where single scattering conditions are usually assumed. We will further develop our recent novel solutions to the phase problem from images and diffraction patterns (needed as a prelude to the inversion) that are robust in the presence of discontinuities in the phase (such as vortices). These phase retrieval methods will be useful not only for problems in electron optics but also in visible, x-ray, neutron and atom optics.Read moreRead less
Atomic resolution imaging and spectroscopy. This project will enhance Australia's reputation in atomic resolution imaging, positioning Australia as a major contributor to significant world research outcomes in the physical sciences. It contributes to the quality of our culture through the advancement of knowledge through the solution of problems of high scientific merit, provides training at the postdoctoral level and will produce several PhD graduates of the highest quality. This project streng ....Atomic resolution imaging and spectroscopy. This project will enhance Australia's reputation in atomic resolution imaging, positioning Australia as a major contributor to significant world research outcomes in the physical sciences. It contributes to the quality of our culture through the advancement of knowledge through the solution of problems of high scientific merit, provides training at the postdoctoral level and will produce several PhD graduates of the highest quality. This project strengthens collaborative international links with one of the worlds leading research facilities located at the Oak Ridge National Laboratory. The potential practical applications of this work should lead to direct economic benefits to Australia.Read moreRead less
Imaging in three dimensions beyond the nanoscale. After two decades of research the first wave of applications in nanotechnology and nanobiology is breaking. The economic stakes are high: nanostructured electronics and photonics will be the next epoch after transistors (1947) and the microprocessor (1971), and designer therapies and drugs will be in high demand. Immediately key to further progress in both areas is the ability to characterize structure in three dimensions at and beyond the nanosc ....Imaging in three dimensions beyond the nanoscale. After two decades of research the first wave of applications in nanotechnology and nanobiology is breaking. The economic stakes are high: nanostructured electronics and photonics will be the next epoch after transistors (1947) and the microprocessor (1971), and designer therapies and drugs will be in high demand. Immediately key to further progress in both areas is the ability to characterize structure in three dimensions at and beyond the nanoscale. This research project places Australia at the forefront in this endeavour, builds on the national knowledge and skills base in atomic resolution imaging and expands international collaborative research links.Read moreRead less
Quantum Nanotechnology: Concepts to Devices. Just as the technological advances of the past few decades at the micro level fundamentally changed our lives, so too the emerging era of 'quantum nanotechnology' promises to revolutionise our society in the 21st century. This Fellowship will explore and develop critical areas of quantum nanotechnology - absolutely secure communication, nanoscopic level imaging, and exponentially fast computers. Such technology will have far reaching applications in a ....Quantum Nanotechnology: Concepts to Devices. Just as the technological advances of the past few decades at the micro level fundamentally changed our lives, so too the emerging era of 'quantum nanotechnology' promises to revolutionise our society in the 21st century. This Fellowship will explore and develop critical areas of quantum nanotechnology - absolutely secure communication, nanoscopic level imaging, and exponentially fast computers. Such technology will have far reaching applications in all areas of society and provide significant National benefit.Read moreRead less