Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Development and commercialization of novel diagnostic assays for the early detection of acute dengue virus infection. Dengue is an emerging disease of the tropics and is endemic in more than 100 countries with up to 100 million cases annually. Of these, 500,000 result in dengue haemorrhagic fever (DHF), a serious life-threatening complication of dengue virus infection. Dengue activity in northern Australia has increased in recent years with suggestions that it may be coming endemic in this count ....Development and commercialization of novel diagnostic assays for the early detection of acute dengue virus infection. Dengue is an emerging disease of the tropics and is endemic in more than 100 countries with up to 100 million cases annually. Of these, 500,000 result in dengue haemorrhagic fever (DHF), a serious life-threatening complication of dengue virus infection. Dengue activity in northern Australia has increased in recent years with suggestions that it may be coming endemic in this country. Early diagnosis, using NS1 based assays should facilitate containment of such outbreaks through earlier identification, treatment, isolation and strategic mosquito control.Read moreRead less
Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social ....Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social benefits for patients, their families, hospitals and their staff, governments and healthcare organisations could thus result. The developed technology would be non-invasive, compact and relatively inexpensive, and could thus be used in rural and regional hospitals, thereby also benefiting patients in those communities. Read moreRead less
Hybrid Imaging System for Breast Cancer Detection. Due to the ever increasing number of breast cancer mortalities in Australia, there is an urgent need for an efficient and reliable diagnostic imaging system. This research utilises a novel method to build an imaging system, which is accurate and reliable in the early detection of tumours. The work of this fellowship will improve quality of life of Australian women and put us at the international forefront of research in medical imaging, enhancin ....Hybrid Imaging System for Breast Cancer Detection. Due to the ever increasing number of breast cancer mortalities in Australia, there is an urgent need for an efficient and reliable diagnostic imaging system. This research utilises a novel method to build an imaging system, which is accurate and reliable in the early detection of tumours. The work of this fellowship will improve quality of life of Australian women and put us at the international forefront of research in medical imaging, enhancing our already significant international presence in the area. The project will potentially lead to valuable intellectual property for commercialisation opportunities besides strengthening key international collaborations.Read moreRead less
Correction of the Effects of Gradient Field Nonlinearity in Magnetic Resonance Imaging - A Complete 3-Dimensional Approach. The outcomes of this research will have direct benefits to various areas of diagnostic and interventional medicine especially in neurological diseases such as Alzheimer's disease, stroke, multiple sclerosis or brain tumors. The techniques developed in this project will in general enable MRI to provide a higher quality service to the community.
Peripheral aberrations of the human eye. This project will benefit Australia from several perspectives. It will make an important contribution to understanding limitations to peripheral vision of the eye, particularly as a result of refractive surgical intervention. This is important because many Australians will require such surgery. Being able to better measure and correct peripheral aberrations will lead to improved imaging of the eye and thus contribute to improved detection and diagnosis of ....Peripheral aberrations of the human eye. This project will benefit Australia from several perspectives. It will make an important contribution to understanding limitations to peripheral vision of the eye, particularly as a result of refractive surgical intervention. This is important because many Australians will require such surgery. Being able to better measure and correct peripheral aberrations will lead to improved imaging of the eye and thus contribute to improved detection and diagnosis of ophthalmic disease. The study will benefit ophthalmologists, optometrists, and engineers involved in designing visual instruments. This project will provide training in adaptive optics for graduate students not available in any other Australian institution.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560680
Funder
Australian Research Council
Funding Amount
$901,862.00
Summary
Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials. State-of-the-art vibrational mapping and imaging equipment (integrated with a field-emission scanning electron microscope (FESEM) and an atomic force microscope (AFM)) will provide enabling technologies for cutting-edge research in disease diagnosis, identification of pathogens, mapping of the entry and distribution of pharmaceutics into cells, and materials research. An InVia Renishaw Raman spectrometer (sub ....Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials. State-of-the-art vibrational mapping and imaging equipment (integrated with a field-emission scanning electron microscope (FESEM) and an atomic force microscope (AFM)) will provide enabling technologies for cutting-edge research in disease diagnosis, identification of pathogens, mapping of the entry and distribution of pharmaceutics into cells, and materials research. An InVia Renishaw Raman spectrometer (sub-micron spatial positioning and micron spatial resolution) will be interfaced to an FEI Quanta FESEM for combined Raman (spectroscopic), EDS and SEM (morphological) imaging/mapping at the sub-cellular level. Complementary new-generation Raman and IR spectrometer upgrades will provide an integrated world-class equipment platform.Read moreRead less
Improved patient care and image resolution in magnetic resonance imaging. A better understanding of the vibration within MRIs would result in techniques to both improve the image resolution and lower the noise emissions. Direct improvement of health care for Australians will result. Both the patient and the working environment around these scanners will improve as well as image resolution. Presently imaging is possible at the cellular scale, but only through improved MRI stability will imaging r ....Improved patient care and image resolution in magnetic resonance imaging. A better understanding of the vibration within MRIs would result in techniques to both improve the image resolution and lower the noise emissions. Direct improvement of health care for Australians will result. Both the patient and the working environment around these scanners will improve as well as image resolution. Presently imaging is possible at the cellular scale, but only through improved MRI stability will imaging reach the molecular level. Medical research that is linked to MRI imaging can be expected to advance in step with improved image resolution. The resulting knowledge could also be used in other research and industrial areas, including micro- and nano-scale devices, where vibration is a critical performance limiting factor.Read moreRead less
The kinematics of the anterior eye deformation. This project has a potential to benefit Australia from a number of perspectives. The outcomes will provide ophthalmologists and optometrists with currently unavailable knowledge on dynamic behaviour of eye. In particular the research will identify aspects of corneal deformation that in turn will help improve the accuracy of refractive surgeries and aid in the management of glaucoma. Also, the knowledge generated through this project will be of valu ....The kinematics of the anterior eye deformation. This project has a potential to benefit Australia from a number of perspectives. The outcomes will provide ophthalmologists and optometrists with currently unavailable knowledge on dynamic behaviour of eye. In particular the research will identify aspects of corneal deformation that in turn will help improve the accuracy of refractive surgeries and aid in the management of glaucoma. Also, the knowledge generated through this project will be of value to engineers designing advanced clinical instrument for measuring eye parameters. Read moreRead less
Tooth-mic Devices for Monitoring the Efficacy of Home-based Continuous Positive Airway Pressure (CPAP) Technology. Over 800,000 Australians suffer from Obstructive Sleep Apnea (OSA). OSA patients use twice the health resources compared to healthy people. They are 7 times more likely to cause traffic accidents; in NSW up to 43000 accidents/year are due to OSA. OSA is treatable & consequences such as strokes, diabetes & heart attacks are preventable. The standard OSA treatment is home-based Contin ....Tooth-mic Devices for Monitoring the Efficacy of Home-based Continuous Positive Airway Pressure (CPAP) Technology. Over 800,000 Australians suffer from Obstructive Sleep Apnea (OSA). OSA patients use twice the health resources compared to healthy people. They are 7 times more likely to cause traffic accidents; in NSW up to 43000 accidents/year are due to OSA. OSA is treatable & consequences such as strokes, diabetes & heart attacks are preventable. The standard OSA treatment is home-based Continuous Positive Airway Pressure Therapy. Unfortunately, no effective technique exists to measure the efficacy of the treatment. We propose enabling solutions to this problem via developing technology centered on breathing sound analysis. The project proposes joint work with a US-company facilitating access to advanced technology highly beneficial to Australia.Read moreRead less