New high resolution radiation dose mapping of special type polymer-gel dosimeters using mini-MRI scanner of high (4.7 Tesla) magnetic field. Gel dosimeters main advantage is dose determination in 3-dimensions. Their main limitation is low spatial-resolution. We propose fabrication of special-type gels and for the first time use the 4.7 Tesla mini-scanner for dose mapping. Increased magnetic field combined with a small aperture for field dissipation will greatly improve spatial resolution down t ....New high resolution radiation dose mapping of special type polymer-gel dosimeters using mini-MRI scanner of high (4.7 Tesla) magnetic field. Gel dosimeters main advantage is dose determination in 3-dimensions. Their main limitation is low spatial-resolution. We propose fabrication of special-type gels and for the first time use the 4.7 Tesla mini-scanner for dose mapping. Increased magnetic field combined with a small aperture for field dissipation will greatly improve spatial resolution down to micrometers (micro-dosimetry). This new technique will render gel-dosimeters suitable for applications in radiotherapy, industrial and all other radiation fields. Moreover, we will employ new parameter for dose mapping, which is expected to be more sensitive to radiation than the currently used relaxation timesRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454184
Funder
Australian Research Council
Funding Amount
$155,792.00
Summary
Silicon Imaging Device Construction Facility - Wirebonder. The development of state-of-the-art, high precision semiconductor imaging devices (for high energy particle physics, synchrotron science and medical imaging ) requires a significant capability in modern assembly facilities. In constructing test and 'production' modules consisting of fine-grained, multi-channel bare silicon or other semiconductor imaging devices and custom electronic chips, a high-reliability, highly flexible wire-bonding ....Silicon Imaging Device Construction Facility - Wirebonder. The development of state-of-the-art, high precision semiconductor imaging devices (for high energy particle physics, synchrotron science and medical imaging ) requires a significant capability in modern assembly facilities. In constructing test and 'production' modules consisting of fine-grained, multi-channel bare silicon or other semiconductor imaging devices and custom electronic chips, a high-reliability, highly flexible wire-bonding machine is an essential tool. The international reputation from success in several challenging projects under difficult conditions, gained by the Chief Investigators has resulted in several more projects being planned in addition to a foreseen program of device development. A modern wirebonder, to replace the existing 30 year-old machine, has become critical to maintain our leading position in this area.Read moreRead less
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to b ....Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to build a laser device that incorporates a deformable mirror to investigate the interplay between aberrations and visual clarity. This new knowledge is a vital next step to improve laser eye-surgery success.Read moreRead less
Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its applicati ....Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its application in medical technology. Furthermore, the principle of temperature localisation due to thermal interference may provide new insights to account for the cause of conformational changes of proteins that result in diseases.Read moreRead less
Multiphoton microscopy through tissue turbid media. The aim of this proposal is to conduct the collaborative project on multi-photon microscopic imaging through biological tissue, which has been recently initiated between Swinburne University of Technology (SUT) and Massachusetts Institute of Technology (MIT). It will integrate the special skills, two-photon fluorescence endoscopy and second-harmonic coherence tomography, investigated in the respective collaborating institutes, to develop a nove ....Multiphoton microscopy through tissue turbid media. The aim of this proposal is to conduct the collaborative project on multi-photon microscopic imaging through biological tissue, which has been recently initiated between Swinburne University of Technology (SUT) and Massachusetts Institute of Technology (MIT). It will integrate the special skills, two-photon fluorescence endoscopy and second-harmonic coherence tomography, investigated in the respective collaborating institutes, to develop a novel method for detecting/imaging cancer cells that are located at 1 mm below tissue surfaces, while they are still in the early stage to be cured. Consequently, a diagnostic method for early cancer detection particularly through skin tissue becomes possible.Read moreRead less
Effective Microfluidic Cell Sorting using Synergistic Acoustic and Optical manipulation. The fluorescence-activated cell sorting technique alone represented a US$860 million market in worldwide diagnostic and life science research devices for 2004. The development of a faster and cheaper device with similar efficacy, as per the objective of this work, has the potential of supplanting immunological methods of cell sorting and thus yield substantial economic returns to the nation. The research act ....Effective Microfluidic Cell Sorting using Synergistic Acoustic and Optical manipulation. The fluorescence-activated cell sorting technique alone represented a US$860 million market in worldwide diagnostic and life science research devices for 2004. The development of a faster and cheaper device with similar efficacy, as per the objective of this work, has the potential of supplanting immunological methods of cell sorting and thus yield substantial economic returns to the nation. The research activities in this project will strengthen Australia's research standing in the fields of microfluidics and lab-in-a-chip technologies. On a broader platform, it will contribute to Australia's high standing in the field of biotechnology.Read moreRead less
Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive li ....Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive lives. Since 1 in 3 Australians will feel the effects of cancers, development of portable nonlinear optical endoscopes is of national importance, in particular for rural Australia, and therefore improves the healthcare of human beings. The potential spin-off activity will lead to economic benefits from new R&D development.Read moreRead less
ARC/NHMRC Research Network Fluorescence Applications in Biotechnology and Life Sciences. This Network will concentrate Australian research in new applications of fluorescence to biological systems to solve significant problems in health diagnostics, biotechnology and the environment. The scientific goals identified by the Network such as highly selective fluorescent labelling and purpose-engineered fluorochromes will be accompanied by the development of specialised instrumentation. These resear ....ARC/NHMRC Research Network Fluorescence Applications in Biotechnology and Life Sciences. This Network will concentrate Australian research in new applications of fluorescence to biological systems to solve significant problems in health diagnostics, biotechnology and the environment. The scientific goals identified by the Network such as highly selective fluorescent labelling and purpose-engineered fluorochromes will be accompanied by the development of specialised instrumentation. These research directions pursued by strong multi-disciplinary teams spanning biology, chemistry, physics, bioengineering and medicine will benefit from the support of the Network programs. Through its focus on academic - industry collaboration the Network will also facilitate development of basic scientific discoveries into commercial outcomes.Read moreRead less
Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is curre ....Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is currently hampered by our inability to separate the composite resonances in a one dimensional MR spectrum. Research will allow two dimensional MRS to be implemented and provide detailed chemical information on human organs in vivo. Read moreRead less