Hybrid radiofrequency/optical catheter for effective atrial fibrillation ablation. This research project aims to advance engineering knowledge by applying an innovative, fibre-optics-based discrete optical coherence tomography to technology used for atrial fibrillation catheter ablation. RadioFrequency catheter-based ablation is far superior to cardiac drug therapy for atrial fibrillation patients. RadioFrequency catheters are not equipped with real-time lesion formation monitoring means, which ....Hybrid radiofrequency/optical catheter for effective atrial fibrillation ablation. This research project aims to advance engineering knowledge by applying an innovative, fibre-optics-based discrete optical coherence tomography to technology used for atrial fibrillation catheter ablation. RadioFrequency catheter-based ablation is far superior to cardiac drug therapy for atrial fibrillation patients. RadioFrequency catheters are not equipped with real-time lesion formation monitoring means, which enable the assessment of continuity-transmurality and prevent extra-cardiac complications, such as steam pops. Optical Coherece Tomography enables non-invasive, microscopic lesion formation assessment in real time during atrial fibrillation ablation procedures. The expected outcomes of this project are to develop a new hybrid fibre-optic/RadioFrequency catheter system and user-friendly driving software that will enable cardiac electrophysiologists to perform three key tasks not previously available.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100035
Funder
Australian Research Council
Funding Amount
$4,743,710.00
Summary
ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to devel ....ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to develop ‘smart’ probes and ‘smart’ scanning, harnessing the digital revolution for better, cost effective diagnostic imaging and improved health outcomes.Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100024
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, internatio ....ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, international collaborations and a generation of industry-ready researchers critical for growing Australia’s industry. The advances in materials and savings in time for procedures will reduce costs.
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Development Of Microscope-in-a-needle Devices For Improved Clinical Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$327,746.00
Summary
We have developed a new high-resolution optical imaging technology. The unique aspect of our research has been to redesign the imaging probe, miniaturising it to a few hundred microns in diameter, and encase it in a hypodermic needle – a ‘microscope-in-a-needle’. We are developing specific imaging probes to aid in the assessment of lung disease; the diagnosis of liver disease; and integrated into a brain biopsy needle to enable safer brain biopsies.
A nanoengineered solution to drug delivery in bone. This project presents an exciting new approach of applying nanotechnology to bone research. By combining our expertise in nanoengineering of new materials, mathematical modelling and bone biology, this project will result in a well-characterised model for drug delivery into bone and lead to a new therapeutic approach for treating bone diseases.
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
X-Ray Activation of Photocatalytic Titania-Coated Biomedical Implants in Situ. The main causes of biomedical implant failure are loosening and infection, which may require revision surgery. The project has the potential to solve these widespread and expensive problems by formation of a coating of strongly (chemically) bonded and photocatalytically active titania on the titanium implant surface and short-term low-dose X-irradiation. This work has the potential to provide the biomedical industry w ....X-Ray Activation of Photocatalytic Titania-Coated Biomedical Implants in Situ. The main causes of biomedical implant failure are loosening and infection, which may require revision surgery. The project has the potential to solve these widespread and expensive problems by formation of a coating of strongly (chemically) bonded and photocatalytically active titania on the titanium implant surface and short-term low-dose X-irradiation. This work has the potential to provide the biomedical industry with a revolutionary development in both implant coating design and quality with self-disinfection capacity after implantation.Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH170100013
Funder
Australian Research Council
Funding Amount
$2,962,655.00
Summary
ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed device ....ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed devices, analytics and integration platforms. New jobs and improved care will see cost reductions, better use of resources and enhanced mental, physical and social well-being.Read moreRead less