Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Development of class-leading bioluminescence resonance energy transfer technologies for real-time monitoring of molecular interactions. The purpose of this project is to develop improved technologies for identifying and developing pharmaceuticals with fewer side effects. The expected outcome is the development of technologies that provide a level of sensitivity and data quality that enables adoption by the biotechnology and pharmaceutical industries.
Development of a prime-boost anti-cancer vaccine. New vaccination strategies are urgently needed for a variety of diseases, including cancer. The problem with cancer vaccines is that it is difficult to trigger a response to a self protein. We propose that a prime-boost vaccination, using yellow fever virus and modified vaccinia virus ankara, could create very strong responses against tumor antigens. This approach can be patented and can revive that field of tumor vaccination, which is currently ....Development of a prime-boost anti-cancer vaccine. New vaccination strategies are urgently needed for a variety of diseases, including cancer. The problem with cancer vaccines is that it is difficult to trigger a response to a self protein. We propose that a prime-boost vaccination, using yellow fever virus and modified vaccinia virus ankara, could create very strong responses against tumor antigens. This approach can be patented and can revive that field of tumor vaccination, which is currently restrained by the difficulty of breaking immunological tolerance. We envisage the construction of a anti-cancer vaccine vector with obvious market potential. An exciting prospect is that this approach could be used as a prophylactic vaccine and possibly also as a therapeutic vaccine.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239218
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Proteomics facility for biotechnology research in WA. The aim of this application is to establish a fully functional proteomics facility to underpin the future research of many groups in four WA institutions. While molecular biological research has thus far concentrated on molecular genetics, it is now vital to directly examine the patterns of proteins expressed by cells to understand their molecular mechanisms. Individual WA researchers have already ventured into proteomics, utilising facilit ....Proteomics facility for biotechnology research in WA. The aim of this application is to establish a fully functional proteomics facility to underpin the future research of many groups in four WA institutions. While molecular biological research has thus far concentrated on molecular genetics, it is now vital to directly examine the patterns of proteins expressed by cells to understand their molecular mechanisms. Individual WA researchers have already ventured into proteomics, utilising facilities located elsewhere in Australia. The reliance on other groups to conduct their proteomics, which are rapidly becoming basic techniques for competitive molecular biological research, is a serious obstacle to biotechnological research in WA.Read moreRead less
Special Research Initiatives - Grant ID: SR0354766
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Molecular farming: seizing the opportunity to establish a new technology based, value adding industry in and for Australia. Molecular farming involves the production of novel products in plants and brings together the technology to genetically modify plants to produce these products with efficient production of plant biomass. The range of potential products is very broad and includes therapeutic and industrial proteins, bioplastics, fibres, food additives, glues and dyes. The molecular farming i ....Molecular farming: seizing the opportunity to establish a new technology based, value adding industry in and for Australia. Molecular farming involves the production of novel products in plants and brings together the technology to genetically modify plants to produce these products with efficient production of plant biomass. The range of potential products is very broad and includes therapeutic and industrial proteins, bioplastics, fibres, food additives, glues and dyes. The molecular farming industry is already established in North America with products on the market. Australia has an outstanding opportunity to participate in this new industry as a producer if we can aggregate the critical scientific mass and work together with the current fledgling industry and State and Federal regulators.Read moreRead less