Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775726
Funder
Australian Research Council
Funding Amount
$306,270.00
Summary
Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizati ....Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizations and industry with state-of-the-art genomic data storage and analysis capability, which will permit both public and proprietary access, and accelerate Australian research and development in genetic medicine, pharmaceuticals, animal breeding and biodiversity.Read moreRead less
Bioreactors for manufacture of human platelets. Blood cell transfusion is a critical part of medicine that is supported by volunteer donors. Unfortunately, the demand for blood cells for transfusion far outstrips supply and therefore new strategies are required for manufacture of blood cells. This project will lead to the development of technology for manufacture of human platelets from stem cells. The systems devised will be applicable to a broad range of other blood cell types.
New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454209
Funder
Australian Research Council
Funding Amount
$126,326.00
Summary
A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds a ....A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds are requested for state of the art HPLC equipment, associated equipment and reagents for glycan purification/labelling, and a staff member, that are all essential to establish this technology in Australia. The Facility will support $25 million of existing research; approximately half of which is derived from ARC.Read moreRead less