Role of water in earth and planetary evolution. This project aims to understand the role of water in the building of our solar system, Mars and Earth. Surprisingly little is known about key issues surrounding the origin of water and its subsequent recycling on Earth. This project will use new techniques for measuring low abundances of water along with oxygen isotopes, to measure water abundances and oxygen isotopes in meteorites and terrestrial rocks to establish how water was delivered to Earth ....Role of water in earth and planetary evolution. This project aims to understand the role of water in the building of our solar system, Mars and Earth. Surprisingly little is known about key issues surrounding the origin of water and its subsequent recycling on Earth. This project will use new techniques for measuring low abundances of water along with oxygen isotopes, to measure water abundances and oxygen isotopes in meteorites and terrestrial rocks to establish how water was delivered to Earth and to understand how water is geologically recycled. This is expected to have direct bearing on where and how Earth's water originated, how water is retained in mantle and crustal minerals and it will have broad implications for understanding volcanic hazards and formation of ore deposits. This will lead to a new capability for combined water and oxygen isotope analysis in Australian geoscience leading to technological development and commercialisation of instrumentation.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of posit ....Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of positron transport in PET. The project will allow validation of predictions from the model by undertaking experiments in liquid water.Read moreRead less
Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock ....Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock for oxygen isotope compositions at unprecedented precision. This project aims to characterise a suite of carbonaceous chondrites, which appear to be the best match to Ryugu, and therefore will provide the exemplar data to understand the provenance of Ryugu, and place it in the context of solar system materials.
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Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to rev ....Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to revolutionise many aspects of modern life, from computing and communications, to medical imaging and metrology. This project will put Australia at the international forefront of quantum imaging, enhancing Australia's already significant international presence in the area.Read moreRead less
Discovery and applications of circular proteins. The many national benefits that will flow from this program include (i) new knowledge in plant biochemistry, peptide chemistry and protein engineering protected by a strong intellectual property position that will give Australia a competitive edge in relevant biotechnology applications; (ii) the training of a new generation of skilled researchers to drive a sustainable biotechnology sector in Australia; (iii) economic benefits from royalty returns ....Discovery and applications of circular proteins. The many national benefits that will flow from this program include (i) new knowledge in plant biochemistry, peptide chemistry and protein engineering protected by a strong intellectual property position that will give Australia a competitive edge in relevant biotechnology applications; (ii) the training of a new generation of skilled researchers to drive a sustainable biotechnology sector in Australia; (iii) economic benefits from royalty returns on drugs and agricultural products that will likely arise from the program; (iv) environment benefits due to a reduced need for chemical insecticides; and (v) social benefits due to a reduction in suffering from diseases for which drugs are developed as a result of this program.Read moreRead less
A novel approach for controlling insect vectors of human disease. Insects are responsible for transmitting a wide variety of debilitating human diseases such as malaria, dengue and yellow fever. Unfortunately, there are very few options available for controlling these insect pests. This project will develop a novel, eco-friendly approach for control of mosquitoes and other important disease vectors.