Scaling-up microstructured fibres for terahertz radiation. Terahertz radiation is the last region of the electromagnetic spectrum to be fully utilised. Many applications have been identified but their practicality has been limited by a lack of low-loss flexible waveguides. The waveguides to be developed in this project will build on Australia's existing international lead and investments in photonics as well as extend the dynamic field of microstructured optical fibres, indentified as the 'futur ....Scaling-up microstructured fibres for terahertz radiation. Terahertz radiation is the last region of the electromagnetic spectrum to be fully utilised. Many applications have been identified but their practicality has been limited by a lack of low-loss flexible waveguides. The waveguides to be developed in this project will build on Australia's existing international lead and investments in photonics as well as extend the dynamic field of microstructured optical fibres, indentified as the 'future' of optical fibres. Low-loss flexible waveguides will enable imaging and spectroscopy applications that can reveal and object's internal structure and composition. This will have immediate applications in security, quality control, medical imaging and other safety or industrial applications.Read moreRead less
Exposure dating with manganese-53, neon-21 and beryllium-10: a new toolkit for studying long-term landscape evolution. Australia today is the driest inhabited continent but this was not always the case. Tens of millions of years ago the climate of Australia was considerably wetter. Then, several million years ago, aridity in Australia developed producing most of the desert features of the red Centre that we see today. The age of our deserts and other arid features are not, however, well known. T ....Exposure dating with manganese-53, neon-21 and beryllium-10: a new toolkit for studying long-term landscape evolution. Australia today is the driest inhabited continent but this was not always the case. Tens of millions of years ago the climate of Australia was considerably wetter. Then, several million years ago, aridity in Australia developed producing most of the desert features of the red Centre that we see today. The age of our deserts and other arid features are not, however, well known. This project will determine the age of desertification in Australia, thereby enhancing our understanding of such processes and the response of our landscape to changing climate.
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Development of direct-write focussed electron beam processing techniques for nano-fabrication applications. The burgeoning disciplines of nanotechnology and biotechnology have the potential to deliver breakthroughs in science and engineering that will revolutionise many aspects of everyday life. Progress in these emerging fields, however, requires parallel advances in the techniques used to fabricate, manipulate and characterise materials and devices at the nanoscale. This project will provide s ....Development of direct-write focussed electron beam processing techniques for nano-fabrication applications. The burgeoning disciplines of nanotechnology and biotechnology have the potential to deliver breakthroughs in science and engineering that will revolutionise many aspects of everyday life. Progress in these emerging fields, however, requires parallel advances in the techniques used to fabricate, manipulate and characterise materials and devices at the nanoscale. This project will provide such enabling tools and fill a major gap in the research infrastructure urgently required by these exciting new technologies.Read moreRead less
Nanoparticle fluorescent labels as a platform for high throughput data gathering. Recent developments in genomics require gathering of vast amounts of information in a rapid and cost-effective fashion. To this aim we will develop a new fluorescent labelling technology with adequate throughput and high level of multiplexing. We will exploit recent advances in nanoparticle science combined with our own discoveries concerning rare earth ions as fluorescence activators. Our approach promises a combi ....Nanoparticle fluorescent labels as a platform for high throughput data gathering. Recent developments in genomics require gathering of vast amounts of information in a rapid and cost-effective fashion. To this aim we will develop a new fluorescent labelling technology with adequate throughput and high level of multiplexing. We will exploit recent advances in nanoparticle science combined with our own discoveries concerning rare earth ions as fluorescence activators. Our approach promises a combination of great technological simplicity, low fabrication costs, cutting edge performance and gives an additional time-resolved modality. Our fluorescent labels will be field-tested to search for yet unknown microorganisms.Read moreRead less
Refinement of dynamic combinatorial chemistry as a drug discovery tool. Medicinal chemistry is constantly being challenged to develop efficient methodologies for the synthesis of compounds for drug discovery. Following completion of the Human Genome project, the cloning and expression of new proteins will proceed at an accelerated rate. In the absence of biochemical knowledge of the target protein there is a growing interest in techniques that expand the structural and biological diversity of co ....Refinement of dynamic combinatorial chemistry as a drug discovery tool. Medicinal chemistry is constantly being challenged to develop efficient methodologies for the synthesis of compounds for drug discovery. Following completion of the Human Genome project, the cloning and expression of new proteins will proceed at an accelerated rate. In the absence of biochemical knowledge of the target protein there is a growing interest in techniques that expand the structural and biological diversity of compound libraries. Dynamic combinatorial chemistry is an innovative technology with the capacity for supporting the shift from focussed to diverse compound libraries. This application seeks funding to refine dynamic combinatorial chemistry into an effective drug discovery tool.Read moreRead less
Structure of Exotic Neutron-Rich Nuclei Populated Using Novel Reaction Mechanisms. Over half of the nuclei believed to be stable to particle decay have not been studied due to the lack of available nuclear reactions. We have played a leading role in developing innovative techniques using incomplete-fusion and deep-inelastic reactions to access neutron-rich nuclei that were inaccessible prior to this work. This project aims to study new phenomena in exotic, neutron-rich nuclei, building on Aust ....Structure of Exotic Neutron-Rich Nuclei Populated Using Novel Reaction Mechanisms. Over half of the nuclei believed to be stable to particle decay have not been studied due to the lack of available nuclear reactions. We have played a leading role in developing innovative techniques using incomplete-fusion and deep-inelastic reactions to access neutron-rich nuclei that were inaccessible prior to this work. This project aims to study new phenomena in exotic, neutron-rich nuclei, building on Australia's existing investment in this area, and, through international scientific leadership, facilitating the access of Australian researchers to highly competitive overseas facilities.Read moreRead less
Dual wavelength quantum dot light detectors. This project aims to develop technologies to fabricate advanced electronic materials based on gallium antimonide (GaSb), to explore their physics and use them in improved optoelectronic devices.
GaSb technology is in its infancy, therefore basic and applied research is needed to utilise these materials to their full potential for long wavelength photonic devices with unique promise in military and civilian applications: fire detection, missile and ....Dual wavelength quantum dot light detectors. This project aims to develop technologies to fabricate advanced electronic materials based on gallium antimonide (GaSb), to explore their physics and use them in improved optoelectronic devices.
GaSb technology is in its infancy, therefore basic and applied research is needed to utilise these materials to their full potential for long wavelength photonic devices with unique promise in military and civilian applications: fire detection, missile and surveillance systems, environmental monitoring, biology and medicine.
As an outcome, growth protocols for innovative device structures will be established, the structures' behaviour assessed and device fabrication and characterisation carried out and reported.
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Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively ....Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively in tissues where adenosine is elevated. Whilst the development of drugs that protect against heart attack and stroke is a difficult and long term objective, any advances toward this goal would clearly be of great benefit to the community.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide ....Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.Read moreRead less