Dark-field: A new kind of x-ray imaging. This project aims to develop new x-ray imaging capabilities that look inside an object and map out those details that are too small to be seen directly, by extracting the dark-field which is produced as x-ray light scatters. Dark-field images can reveal tiny cracks in manufactured parts, discover powdered explosives or drugs during security screening, and detect changes in the size of the many tiny air sacs in the lungs. Expected outcomes of this project ....Dark-field: A new kind of x-ray imaging. This project aims to develop new x-ray imaging capabilities that look inside an object and map out those details that are too small to be seen directly, by extracting the dark-field which is produced as x-ray light scatters. Dark-field images can reveal tiny cracks in manufactured parts, discover powdered explosives or drugs during security screening, and detect changes in the size of the many tiny air sacs in the lungs. Expected outcomes of this project include new instruments and methods of analysis that will allow x-ray dark-field imaging to be quantitative and widely adopted. These methods should benefit non-invasive multi-scale imaging at the Australian Synchrotron and equip x-ray imaging in industry, security and healthcare.Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
X-ray Ghost Imaging and Tomography. This project aims to achieve safer, faster, and cheaper 3D X-ray imaging through a technique known as ghost imaging. X-ray imaging provides valuable information about internal structures, however, X-rays are carcinogenic and exposure (or dose) should be limited. Ghost imaging is an unconventional technique developed with visible light that has many potential benefits over conventional imaging. This research group are world leaders in ghost imaging and expect t ....X-ray Ghost Imaging and Tomography. This project aims to achieve safer, faster, and cheaper 3D X-ray imaging through a technique known as ghost imaging. X-ray imaging provides valuable information about internal structures, however, X-rays are carcinogenic and exposure (or dose) should be limited. Ghost imaging is an unconventional technique developed with visible light that has many potential benefits over conventional imaging. This research group are world leaders in ghost imaging and expect to develop software and hardware techniques to realise its potential and extend it to ghost tomography. The focus of this project is on reducing cancer risk in medical imaging, and allowing real-time quality control for 3D printing in safety-critical industries such as aerospace.Read moreRead less
A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce ....A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce a platform technology designed for subscalp anatomy with future use in various brain-machine interfacing applications relying on reliable, long-term and easy-to-implant systems. This project's device manufacturing, training, and intellectual property are expected to strengthen Australia's position in bioelectronics.Read moreRead less
Bioinspired Flexible Haptic Memory Materials for Artificial Sensory Nerves. This project aims to develop next generation haptic memory materials for the applications of artificial sensory nerves, which can precisely detect, process and respond to mechanical stimuli. The project expects to achieve this aim by mimicking the functions of biological haptic memory system and integrating highly sensitive tactile sensors and synaptic devices into artificial sensory nerves. The anticipated outcomes wil ....Bioinspired Flexible Haptic Memory Materials for Artificial Sensory Nerves. This project aims to develop next generation haptic memory materials for the applications of artificial sensory nerves, which can precisely detect, process and respond to mechanical stimuli. The project expects to achieve this aim by mimicking the functions of biological haptic memory system and integrating highly sensitive tactile sensors and synaptic devices into artificial sensory nerves. The anticipated outcomes will be new electronic materials for a wide range of end uses in next-generation flexible sensor technologies including healthcare monitoring devices, intelligent soft robotic systems and neural prosthetics.Read moreRead less
Biophysics-informed deep learning framework for magnetic resonance imaging. This project aims to bring about a paradigm shift from the conventional non-quantitative magnetic resonance imaging to ultra-fast, quantitative, and artefact free imaging. This project integrates biophysics and artificial intelligence, and it is expected to bring new knowledge in both fields. The expected outcomes of this project include next generation magnetic resonance imaging methods with a fundamental shift in the ....Biophysics-informed deep learning framework for magnetic resonance imaging. This project aims to bring about a paradigm shift from the conventional non-quantitative magnetic resonance imaging to ultra-fast, quantitative, and artefact free imaging. This project integrates biophysics and artificial intelligence, and it is expected to bring new knowledge in both fields. The expected outcomes of this project include next generation magnetic resonance imaging methods with a fundamental shift in the approach to image artefacts and image quantification. This project is expected to advance both single subject and population level biomedical imaging with greater accuracy and cost-effectiveness. This project also promotes explainable and generalisable artificial intelligence in medical imaging.Read moreRead less
Laser emission at the limit of glass transparency using nanocrystal doping . We will create a new composite glass providing strong fluorescence which fully exploits the high transmission of glass in the mid-infrared. When combined with emerging rare earth ion transitions and precise excitation processes, this project will help solve an important problem in optics; that the overall efficiency and power produced from deep mid-infrared light sources is not sufficient for all industries. The primary ....Laser emission at the limit of glass transparency using nanocrystal doping . We will create a new composite glass providing strong fluorescence which fully exploits the high transmission of glass in the mid-infrared. When combined with emerging rare earth ion transitions and precise excitation processes, this project will help solve an important problem in optics; that the overall efficiency and power produced from deep mid-infrared light sources is not sufficient for all industries. The primary outcome will be a series of robust fibre-based gain modules suitable for high power and very short optical pulses in the mid-infrared. These light sources will beneficially impact medicine, defence, sensing and manufacturing providing excellent opportunities for increasing Australian productivity and global competitiveness. Read moreRead less
How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluores ....How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluorescence microscope previously developed that can locate the position of proteins with 2 nanometer resolution. The expected outcomes of this project is a class of biosensor that can continuously monitor protein biomarkers for wearable sensors that provide information on a user’s wellness and nutrition.Read moreRead less
Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could l ....Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could lead to improved disease management and eradication programs through identification and treatment of drug resistant pathogens in individuals that have the potential to re-infect the community.Read moreRead less
Photoacoustic cellular manipulation: building from the bottom up. In this project we propose an approach for creating complex 3D prints. Whereas current approaches are limited to defining the external geometry, this technology will permit the organization of the internal structure as well, with the potential to do so at the scale of individual cells. Achieving this has important applications in bioprinting human tissues and additive manufacturing. This is based on the manipulation of particles a ....Photoacoustic cellular manipulation: building from the bottom up. In this project we propose an approach for creating complex 3D prints. Whereas current approaches are limited to defining the external geometry, this technology will permit the organization of the internal structure as well, with the potential to do so at the scale of individual cells. Achieving this has important applications in bioprinting human tissues and additive manufacturing. This is based on the manipulation of particles and cells using holographic acoustic fields controlled by patterned light. This is compared to current acoustic patterning approaches are mostly limited to static simple geometric arrangements and lack the flexibility to produce arbitrary, rapidly changing fields that enable the fabrication of complex structures. Read moreRead less