Understanding surface acoustic wave atomisation for pulmonary delivery of drug aerosols in personalised medicine. Delivering drugs via the lung is hampered by development costs and inadequate technology. This project will provide an understanding of atomisation in our unique respire system, enabling not only the delivery of new vaccines and drugs but also the rapid and cost effective development of new disease treatments personalised to the patient.
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Acoustic trapping for life science applications. Force fields can be established to move suspended cells into predefined locations using high frequency vibration; randomly dispersed cells can be brought together into clusters. This project aims to develop such technologies and will have applications in drug discovery and cell to cell interaction studies and has the future potential to promote the health of Australians.
3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabiliti ....3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabilities in micro-optical probes for industrial environments, establishing new solutions for international astronomy partners, and developing new techniques to image through optical fibres. This should provide significant benefits by improving astronomical instrumentation and also lead to less invasive endoscopy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100175
Funder
Australian Research Council
Funding Amount
$475,000.00
Summary
A high-payload, high-fidelity haptically-enabled motion simulation facility. An Australian-first motion simulation facility consisting of a high-payload, high-fidelity Stewart platform mounted on a dual-axis linear track is proposed. The facility will allow high acceleration and high vibration manoeuvres, and large displacements through an eight-degrees-of-freedom range of motion. It can carry the entire control compartment of a heavy vehicle, a truck, an ambulance, a train, or a multi-operator ....A high-payload, high-fidelity haptically-enabled motion simulation facility. An Australian-first motion simulation facility consisting of a high-payload, high-fidelity Stewart platform mounted on a dual-axis linear track is proposed. The facility will allow high acceleration and high vibration manoeuvres, and large displacements through an eight-degrees-of-freedom range of motion. It can carry the entire control compartment of a heavy vehicle, a truck, an ambulance, a train, or a multi-operator cockpit of a mining vehicle for simulation. The outcome will provide significant benefits for virtual vehicle prototyping and testing, driver training and behaviour modelling, motion perception and motion sickness research; therefore advancing Australia as the global leader in motion simulation and vehicular technologies.Read moreRead less
Harnessing sperm dynamics in microfluidic sorting technologies. Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome i ....Harnessing sperm dynamics in microfluidic sorting technologies. Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome is the next generation technology for sperm sorting and analysis. This should provide significant benefits, such as new biophysical insights into mammalian reproduction, with potential for future improvement of assisted reproduction technologies – a field in which Australia has a world leading history.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100079
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
A haptic-based immersive motion platform for human performance evaluation. A haptic-based immersive motion platform for human performance evaluation: This project aims to establish a motion platform capable of combining continuous centrifugal rotation and large linear displacement with an additional five degrees of motion. The system will house a human subject at the end of a large serial robot similar to a human arm, which can rotate continuously about its base. The robot arm will be installed ....A haptic-based immersive motion platform for human performance evaluation. A haptic-based immersive motion platform for human performance evaluation: This project aims to establish a motion platform capable of combining continuous centrifugal rotation and large linear displacement with an additional five degrees of motion. The system will house a human subject at the end of a large serial robot similar to a human arm, which can rotate continuously about its base. The robot arm will be installed on a large linear axis enabling the simulation of movements and accelerations along a straight path as well as rotation provided by other axes of the robot. The motion platform will comprise audio and visual devices, and haptic-based control mechanisms, for example a steering wheel and pedals or a helicopter cyclic, to provide a number of human immersed scenarios for driving/flying training and human perception evaluation.Read moreRead less
Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied ....Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied at a population level. To trap single cells, the acoustic wavelength excited must be reduced to the order of a cell diameter. By enabling the analysis of different responses due to subtle cell difference, information pertinent to infection pathways and drug response could be gathered.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102352
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Three-dimensional structural imaging in optical microscopy and tomography. This project will develop fundamentally new strategies for looking inside live cells to determine their internal structures. Such capability will permit a better understanding of diseases, the link between diabetes and heart failure for example, opening the door for new diagnostic techniques and treatments.