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Australian Laureate Fellowships - Grant ID: FL110100196
Funder
Australian Research Council
Funding Amount
$2,638,208.00
Summary
New dimensions in organic bionics. The advent of the next generation of medical bionic devices is critically dependent on advances in multifunctional organic materials that, like living systems, provide spatial and temporal control. These advances will provide a platform to revolutionise medical treatments such as nerve and muscle regeneration, with impact on neural prosthetics.
Australian Laureate Fellowships - Grant ID: FL0992016
Funder
Australian Research Council
Funding Amount
$2,064,351.00
Summary
Frontiers of Precision Time and Frequency. Devices for precise frequency and time metrology invented at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, astronomy, tests of fundamental physics and have attracted worldwide interest. This project will strengthen Australian "know how" and expertise, and place us in a position to participate in current and future space missions. Moreover, this repres ....Frontiers of Precision Time and Frequency. Devices for precise frequency and time metrology invented at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, astronomy, tests of fundamental physics and have attracted worldwide interest. This project will strengthen Australian "know how" and expertise, and place us in a position to participate in current and future space missions. Moreover, this represents an opportunity for high profile involvement as the only southern hemisphere user of the most accurate space clock ever developed, which will likely involve the order of 30 institutes worldwide. This work necessarily includes collaboration with the world's elite metrological institutes.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100185
Funder
Australian Research Council
Funding Amount
$3,269,608.00
Summary
Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bio ....Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bioanalytes directly and continuously in interstitial fluid, sweat, and blood; critically, they will be capable of long-term monitoring. The outcomes are expected to enable development of downstream applications across medical diagnostics, sports sciences, workplace testing as well as defence and space technologies.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100278
Funder
Australian Research Council
Funding Amount
$2,513,348.00
Summary
Hector: a revolutionary survey machine to discover how galaxies formed. Hector: a revolutionary survey machine to discover how galaxies formed. The formation of the Milky Way, is one of the most important questions in cosmology today. One of the key unknowns is how the gas, which forms the stars, gets into dark matter halos to make galaxies and why these galaxies spin. This project aims to assemble a first-rate instrument team to build Hector, the first automated hexabundle spectrograph; to ass ....Hector: a revolutionary survey machine to discover how galaxies formed. Hector: a revolutionary survey machine to discover how galaxies formed. The formation of the Milky Way, is one of the most important questions in cosmology today. One of the key unknowns is how the gas, which forms the stars, gets into dark matter halos to make galaxies and why these galaxies spin. This project aims to assemble a first-rate instrument team to build Hector, the first automated hexabundle spectrograph; to assemble a large team to combine Hector's spectral imaging of 100,000 galaxies with new Australian radio observations; and to extend this technology for the Giant Magellan Telescope. This will help to ensure Australia's leadership in observational cosmology and instrumentation through this decade and into the era of extremely large telescopes.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992138
Funder
Australian Research Council
Funding Amount
$3,100,000.00
Summary
Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial ....Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial treatments; contribute to Australia's continued international leading role in drug discovery research; enhance international links and attract industry investment in Australia; and provide a stimulating research training environment to inspire and motivate the next generation of scientists.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100148
Funder
Australian Research Council
Funding Amount
$2,840,752.00
Summary
Exascale astronomy: real-time analysis of the transient radio universe. Exascale astronomy: real-time analysis of the transient radio universe: This fellowship project aims to develop and deploy a generic supercomputing solution for the powerful square kilometre array precursor telescopes in Australia and South Africa. ‘Fast radio bursts’ are a new astronomical phenomenon of as yet unknown origin, with enormous potential to probe the cosmos in new ways — but only a handful are known. Concurrentl ....Exascale astronomy: real-time analysis of the transient radio universe. Exascale astronomy: real-time analysis of the transient radio universe: This fellowship project aims to develop and deploy a generic supercomputing solution for the powerful square kilometre array precursor telescopes in Australia and South Africa. ‘Fast radio bursts’ are a new astronomical phenomenon of as yet unknown origin, with enormous potential to probe the cosmos in new ways — but only a handful are known. Concurrently, advances in computer graphics have enabled very low-cost parallel processors to be constructed that are revolutionising radio astronomy signal processing. The telescopes in Australia and South Africa will be used to discover new fast radio bursts, and will also be pursuing a pulsar timing program which seeks to probe the interior of neutron stars, search for gravitational waves and make new tests of general relativity.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100096
Funder
Australian Research Council
Funding Amount
$3,367,940.00
Summary
Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by ....Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by defining the mechanism by which such genes control ageing and by identifying biomarkers that predict different ageing outcomes. This knowledge will contribute to future strategies based on genetic testing and biomarkers to optimise healthy ageing in humans. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100072
Funder
Australian Research Council
Funding Amount
$3,460,832.00
Summary
Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances ....Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances in genomic technologies, to build and sustain critical capacity in statistical genetics, and better understand the causes and consequence of individual differences in human traits from genetic and environmental factors across the entire human lifespan.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100160
Funder
Australian Research Council
Funding Amount
$2,568,846.00
Summary
A philosophy of medicine for the 21st century. This project aims to develop a new theory of health and disease to accommodate developments in contemporary biology such as the ‘developmental origins of health and disease’, the role of the microbiome in physiology, and the fact that our bodies are sites of evolutionary conflict between multiple genomes, particularly in early life. Present science does not fit with common-sense ideas about the identity and the goals of living systems and the projec ....A philosophy of medicine for the 21st century. This project aims to develop a new theory of health and disease to accommodate developments in contemporary biology such as the ‘developmental origins of health and disease’, the role of the microbiome in physiology, and the fact that our bodies are sites of evolutionary conflict between multiple genomes, particularly in early life. Present science does not fit with common-sense ideas about the identity and the goals of living systems and the project expects to generate a close collaboration between philosophers and biomedical scientists so that new ideas about health and disease can be fed back into proof-of-principle projects for innovative new approaches to the study of health and disease. The project will conduct methodologically innovative research in the philosophy of medicine, working in close collaboration with biomedical scientists to confront the transformational discoveries about the nature of living systems that have been made in the first years of the current century and to actively shape new forms of enquiry into health that reflect those discoveries. It will make the discipline of philosophy an active participant in the creation of integrative biomedical research.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100139
Funder
Australian Research Council
Funding Amount
$2,965,538.00
Summary
Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processe ....Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processes inside the cell, including proliferation, differentiation and migration. Exactly how the physical and chemical properties of ECMs on the outside of the cell modify the behaviour of a cell on the inside remains unclear. Outcomes would include a blueprint for synthetic ECMs, pushing the boundaries of materials development in the biological and life sciences.Read moreRead less