Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Statistical literacy in the education workplace: Barriers and enablers for school personnel making data-driven decisions. Using quantitative data to monitor workplace processes and improve quality requires both strong statistical literacy and commitment to such decision-making processes. This study of data usage by school personnel will contribute to the success of the National Assessment Program that monitors progress towards the National Goals for Schooling in the 21st Century. It will provide ....Statistical literacy in the education workplace: Barriers and enablers for school personnel making data-driven decisions. Using quantitative data to monitor workplace processes and improve quality requires both strong statistical literacy and commitment to such decision-making processes. This study of data usage by school personnel will contribute to the success of the National Assessment Program that monitors progress towards the National Goals for Schooling in the 21st Century. It will provide evidence from which to enhance professional learning in data interpretation for both pre- and in-service teachers. The resulting research template has application for examining (a) statistical literacy needs in other sectors and (b) workers' perceptions of quantitative data used to inform decision-making. This will enhance the smart use of data in the workplace.Read moreRead less