Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden o ....Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden of annually half a billion dollars on the Australian health budget. Controlling and reducing wear debris in prosthesis joints would reduce these costs and improve patients' quality of life.Read moreRead less
Refinement of dynamic combinatorial chemistry as a drug discovery tool. Medicinal chemistry is constantly being challenged to develop efficient methodologies for the synthesis of compounds for drug discovery. Following completion of the Human Genome project, the cloning and expression of new proteins will proceed at an accelerated rate. In the absence of biochemical knowledge of the target protein there is a growing interest in techniques that expand the structural and biological diversity of co ....Refinement of dynamic combinatorial chemistry as a drug discovery tool. Medicinal chemistry is constantly being challenged to develop efficient methodologies for the synthesis of compounds for drug discovery. Following completion of the Human Genome project, the cloning and expression of new proteins will proceed at an accelerated rate. In the absence of biochemical knowledge of the target protein there is a growing interest in techniques that expand the structural and biological diversity of compound libraries. Dynamic combinatorial chemistry is an innovative technology with the capacity for supporting the shift from focussed to diverse compound libraries. This application seeks funding to refine dynamic combinatorial chemistry into an effective drug discovery tool.Read moreRead less
Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively ....Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively in tissues where adenosine is elevated. Whilst the development of drugs that protect against heart attack and stroke is a difficult and long term objective, any advances toward this goal would clearly be of great benefit to the community.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide ....Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.Read moreRead less
Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Scaling-up microstructured fibres for terahertz radiation. Terahertz radiation is the last region of the electromagnetic spectrum to be fully utilised. Many applications have been identified but their practicality has been limited by a lack of low-loss flexible waveguides. The waveguides to be developed in this project will build on Australia's existing international lead and investments in photonics as well as extend the dynamic field of microstructured optical fibres, indentified as the 'futur ....Scaling-up microstructured fibres for terahertz radiation. Terahertz radiation is the last region of the electromagnetic spectrum to be fully utilised. Many applications have been identified but their practicality has been limited by a lack of low-loss flexible waveguides. The waveguides to be developed in this project will build on Australia's existing international lead and investments in photonics as well as extend the dynamic field of microstructured optical fibres, indentified as the 'future' of optical fibres. Low-loss flexible waveguides will enable imaging and spectroscopy applications that can reveal and object's internal structure and composition. This will have immediate applications in security, quality control, medical imaging and other safety or industrial applications.Read moreRead less
Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing ....Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing the need for revision surgery. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668257
Funder
Australian Research Council
Funding Amount
$1,200,000.00
Summary
Combinatorial Deposition and Characterisation Facility for New Alloy Thin Film Materials. Australia's competitive edge in materials research is key to maintaining our economic prosperity. Infrastructure that enables our researchers to synthesize novel materials with precise control over composition and structure is crucial to maintaining our strengths in this field. The proposed infrastructure will accelerate progress on the preparation and characterisation of new alloy and nanostructured materi ....Combinatorial Deposition and Characterisation Facility for New Alloy Thin Film Materials. Australia's competitive edge in materials research is key to maintaining our economic prosperity. Infrastructure that enables our researchers to synthesize novel materials with precise control over composition and structure is crucial to maintaining our strengths in this field. The proposed infrastructure will accelerate progress on the preparation and characterisation of new alloy and nanostructured materials and will pay dividends by providing early access to the best materials. This will give our energy technology, biomedical engineering, tooling, electronics and mining industries a competitive edge. Access to this new generation equipment will enhance our pool of highly skilled materials technologists.Read moreRead less
Fabrication of robust nanoscale optical biosensors using the novel spinning disc reactor technology. Spinning Disc Reactor (SDR) technology is new to Australia and will have wide ranging applications in nano-technology, and is destined to attract significant industrial interest beyond the proposed application in nano-scale biosensors. SDR is based on continuous flow and is more benign (less chemical waste) than traditional batch technology with a smaller footprint and significantly reduced capit ....Fabrication of robust nanoscale optical biosensors using the novel spinning disc reactor technology. Spinning Disc Reactor (SDR) technology is new to Australia and will have wide ranging applications in nano-technology, and is destined to attract significant industrial interest beyond the proposed application in nano-scale biosensors. SDR is based on continuous flow and is more benign (less chemical waste) than traditional batch technology with a smaller footprint and significantly reduced capital outlay. The emergence of SDR technology will revolutionize the practice of nano-engineering leading to miniaturization of devices, advances in information technologies and intelligent systems, and the revolution in medical science. The exciting research will enhance public opinion towards science.Read moreRead less