Skeletome - A Curated Online Knowledge Base Integrating Clinical and Biological Information on Skeletal Dysplasias and Related Conditions. The skeletal dysplasia knowledge base will:
* establish Australia as a world-leader in skeletal dysplasia research;
* provide researchers with an extensible and comprehensive online knowledge-base related to skeletal dysplasias;
* enhance clinicians' understanding of the diagnosis, treatment and management of skeletal dysplasias;
* facilitate collaborativ ....Skeletome - A Curated Online Knowledge Base Integrating Clinical and Biological Information on Skeletal Dysplasias and Related Conditions. The skeletal dysplasia knowledge base will:
* establish Australia as a world-leader in skeletal dysplasia research;
* provide researchers with an extensible and comprehensive online knowledge-base related to skeletal dysplasias;
* enhance clinicians' understanding of the diagnosis, treatment and management of skeletal dysplasias;
* facilitate collaborative discussions by patients, clinicians and researchers around specific cases to improve training, management and diagnosis; and
* enhance Australia's research expertise in Semantic Web and social networking technologies.Read moreRead less
Understanding health information literacy in Australia's ageing population: A qualitative study. Australians need to know how to find and use information to help them age well. This research will establish a national Health Information Literacy Framework that will be an evidence-based guide for community agencies to use in creating resources and services to support the information needs of ageing Australians. Ageing Australians who are healthy and active are able to participate in the workforce, ....Understanding health information literacy in Australia's ageing population: A qualitative study. Australians need to know how to find and use information to help them age well. This research will establish a national Health Information Literacy Framework that will be an evidence-based guide for community agencies to use in creating resources and services to support the information needs of ageing Australians. Ageing Australians who are healthy and active are able to participate in the workforce, engage in the community while easing the burden on the national health care system. The research will place Australia at the forefront of health prevention and information literacy research. The research will be undertaken as a partnership between QUT, Griffith University and the Health Contact Centre. Read moreRead less
Defining the Status of Culturally and Linguistically Diverse Young People. This project aims to improve the social cohesion of Australian society and the living standards of a significant group of our young people. Around 25 per cent of all Australians aged 12 to 24 are from culturally and linguistically diverse (CALD) backgrounds. In collaboration with nine Australian organisations, the project aims to critically define the status of CALD youth; develop the first national status reporting frame ....Defining the Status of Culturally and Linguistically Diverse Young People. This project aims to improve the social cohesion of Australian society and the living standards of a significant group of our young people. Around 25 per cent of all Australians aged 12 to 24 are from culturally and linguistically diverse (CALD) backgrounds. In collaboration with nine Australian organisations, the project aims to critically define the status of CALD youth; develop the first national status reporting framework for the group that will generate new social, economic and cultural indicators; and build a knowledge hub to store and curate CALD youth data. Data and understanding from this project is intended to enable governments to meet the group’s specific needs and enhance their opportunities.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Development and commercialization of novel diagnostic assays for the early detection of acute dengue virus infection. Dengue is an emerging disease of the tropics and is endemic in more than 100 countries with up to 100 million cases annually. Of these, 500,000 result in dengue haemorrhagic fever (DHF), a serious life-threatening complication of dengue virus infection. Dengue activity in northern Australia has increased in recent years with suggestions that it may be coming endemic in this count ....Development and commercialization of novel diagnostic assays for the early detection of acute dengue virus infection. Dengue is an emerging disease of the tropics and is endemic in more than 100 countries with up to 100 million cases annually. Of these, 500,000 result in dengue haemorrhagic fever (DHF), a serious life-threatening complication of dengue virus infection. Dengue activity in northern Australia has increased in recent years with suggestions that it may be coming endemic in this country. Early diagnosis, using NS1 based assays should facilitate containment of such outbreaks through earlier identification, treatment, isolation and strategic mosquito control.Read moreRead less
Transceive Phased Arrays for Parallel Imaging in High Field Magnetic Resonance Microscopy. This project will contribute to the development of a new generation of Magnetic Resonance Imaging systems that provide new and innovative features capable of significantly increasing the resolution and /or speed of imaging. The economic benefit of being a developer of this technology is clear and significant. These new systems will enhance the efficiency and power of clinical diagnostic testing. Specifica ....Transceive Phased Arrays for Parallel Imaging in High Field Magnetic Resonance Microscopy. This project will contribute to the development of a new generation of Magnetic Resonance Imaging systems that provide new and innovative features capable of significantly increasing the resolution and /or speed of imaging. The economic benefit of being a developer of this technology is clear and significant. These new systems will enhance the efficiency and power of clinical diagnostic testing. Specifically, the enabling of molecular imaging will enhance the study of many more disease states and rapid assessment of new in vivo therapeutic agents. The side-stream benefit to biomedical research and development in Australia is therefore substantial. Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Urinary continence and incontinence in men: New insight through new technologies. Healthy ageing in men is largely overlooked. Disorders of continence are surprisingly common with increasing age, and are socially debilitating. To understand changes in continence and address healthy ageing it is first necessary to gain an understanding of continence mechanisms in healthy men. Continence in women has received wide attention, but anatomy and function differ, as do the challenges throughout life (ch ....Urinary continence and incontinence in men: New insight through new technologies. Healthy ageing in men is largely overlooked. Disorders of continence are surprisingly common with increasing age, and are socially debilitating. To understand changes in continence and address healthy ageing it is first necessary to gain an understanding of continence mechanisms in healthy men. Continence in women has received wide attention, but anatomy and function differ, as do the challenges throughout life (childbirth vs. prostate disease). Using novel methods we will test a new hypothesis of male continence with the goal to provide new physiological discoveries, new methods, and baseline data upon which strategies to enhance healthy ageing and reduce the economic burden of disorders of continence can be developed and refined. Read moreRead less
Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social ....Novel EEG data mining methods for detecting and monitoring brain injury. The outcomes of this project could ultimately help produce novel technology which would enable bedside monitoring of brain function in patients with brain injuries such as stroke. This technology could aid critical care and treatment of such patients. Hence patients' recoveries could be positively affected and the high death or disability rates associated with such conditions could be reduced. A host of economic and social benefits for patients, their families, hospitals and their staff, governments and healthcare organisations could thus result. The developed technology would be non-invasive, compact and relatively inexpensive, and could thus be used in rural and regional hospitals, thereby also benefiting patients in those communities. Read moreRead less