Using genetics to recover Australia's lost history. This project aims to use historic hair samples collected by anthropological expeditions in the early 20th Century to generate the first genetic map of Aboriginal Australia – in order to reconstruct Australia’s pre-European genetic and cultural past. The map and the detailed contextual and genealogical information from museum archives will assist Aboriginal communities and individuals to reconstruct their personal and family history and trace an ....Using genetics to recover Australia's lost history. This project aims to use historic hair samples collected by anthropological expeditions in the early 20th Century to generate the first genetic map of Aboriginal Australia – in order to reconstruct Australia’s pre-European genetic and cultural past. The map and the detailed contextual and genealogical information from museum archives will assist Aboriginal communities and individuals to reconstruct their personal and family history and trace ancestry and augment oral or written records. The combination of cutting-edge science, detailed archival research, and a comprehensive family outreach and reporting program will be a step change in assisting Australia’s reconciliation process, the Stolen Generation, and repatriation of Indigenous remains.Read moreRead less
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted u ....Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted use of chemical insecticides. This in turn can produce secondary economic benefits, e.g. through enhanced growth and profitability of the organic beef industry within the main locust-outbreak area. Read moreRead less
Genomics for persistence of Australian freshwater fish. Biodiversity faces an unpredictable cocktail of impacts and global environmental change, against which the best insurance is genetic diversity. We will develop genomic measures of ecological-genetic functions and evolutionary potential for managing Australian freshwater fish.
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Conservation genomics of a critically endangered insect. This project aims to develop tools genotyping large animal genomes, focusing on the case of the Lord Howe Island stick insect, once thought to be extinct and now critically endangered. This project expects to generate molecular tools to monitor the genetic health the insect which has a large, complex and poorly understood genome. Expected outcomes include the development of a preservation and reintroduction strategy for the insect. This pr ....Conservation genomics of a critically endangered insect. This project aims to develop tools genotyping large animal genomes, focusing on the case of the Lord Howe Island stick insect, once thought to be extinct and now critically endangered. This project expects to generate molecular tools to monitor the genetic health the insect which has a large, complex and poorly understood genome. Expected outcomes include the development of a preservation and reintroduction strategy for the insect. This project will benefit ongoing conservation efforts, and is timely given the ongoing eradication of rats from Lord Howe Island where this species once lived. Read moreRead less
Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will explo ....Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.Read moreRead less
Improving methods of grading, transferring and facilitating translation of knowledge in population health. This project will develop methods by which research in population health can be better used by policy makers. It will develop a grading system to assist research consumers to work out the best evidence. Interviews and surveys of policy makers will be conducted to work out how to optimise the way the best evidence can be used in practice.
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
E. coli as an indicator of faecal contamination in the Australian context. The goal of this research is to improve our ability to use Escherichia coli as an indicator of water quality by determining the extent to which non-faecal sources of E. coli contribute to coliform counts and to develop a method to differentiate non-faecal E. coli from those that are faecal derived.