A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Dielectric contrast imaging for 7 Tesla magnetic resonance applications. This project aims to develop novel radio-frequency (RF) technology, ensuring that the benefits of high-field magnetic resonance imaging (MRI) are available for a broader range of applications. This project will develop a new contrast mechanism directly related to the RF properties of individual tissue types, circumventing a limitation of intensity based imaging. This technology will enhance Australia’s global impact the dev ....Dielectric contrast imaging for 7 Tesla magnetic resonance applications. This project aims to develop novel radio-frequency (RF) technology, ensuring that the benefits of high-field magnetic resonance imaging (MRI) are available for a broader range of applications. This project will develop a new contrast mechanism directly related to the RF properties of individual tissue types, circumventing a limitation of intensity based imaging. This technology will enhance Australia’s global impact the development of imaging technology for healthcare, biomedical research and advanced diagnostics.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
Understanding surface acoustic wave atomisation for pulmonary delivery of drug aerosols in personalised medicine. Delivering drugs via the lung is hampered by development costs and inadequate technology. This project will provide an understanding of atomisation in our unique respire system, enabling not only the delivery of new vaccines and drugs but also the rapid and cost effective development of new disease treatments personalised to the patient.
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied ....Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied at a population level. To trap single cells, the acoustic wavelength excited must be reduced to the order of a cell diameter. By enabling the analysis of different responses due to subtle cell difference, information pertinent to infection pathways and drug response could be gathered.Read moreRead less
Integration of DNA switches into wearables for smart chemical monitoring. This project addresses the scientific challenge of real-time monitoring of dynamic biological changes in the secretions found in sweat. By creating a wearable wireless device to monitor chemicals which interests Nutromics, using a novel electronic skin technology platform, the work aims to generate new knowledge of physiological changes in sweat secretions. Lying at the interface of analytical chemistry, functional materia ....Integration of DNA switches into wearables for smart chemical monitoring. This project addresses the scientific challenge of real-time monitoring of dynamic biological changes in the secretions found in sweat. By creating a wearable wireless device to monitor chemicals which interests Nutromics, using a novel electronic skin technology platform, the work aims to generate new knowledge of physiological changes in sweat secretions. Lying at the interface of analytical chemistry, functional materials and biomedical engineering, the project will contribute to the training of young researchers in these emerging technologies which interest Nutromics Pty Ltd. The project will improve Australia's standing in technology around wearable devices, improving our global competitive edge with economic and scientific impact.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100124
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Rapid prototyping 3-D nano-pattern large area writer . Rapid prototyping 3-D nano-pattern large area writer:
The project aims to establish a nanoscale three-dimensional patterning rapid prototyping capability to enable advanced nanofabrication research and development. The extension of patterning nanostructured materials in three dimensions with nanometre resolution, developed for semiconductor processing, to nano-electronics, nanophotonics, nanosensors, nanobiotechnology and fundamental studi ....Rapid prototyping 3-D nano-pattern large area writer . Rapid prototyping 3-D nano-pattern large area writer:
The project aims to establish a nanoscale three-dimensional patterning rapid prototyping capability to enable advanced nanofabrication research and development. The extension of patterning nanostructured materials in three dimensions with nanometre resolution, developed for semiconductor processing, to nano-electronics, nanophotonics, nanosensors, nanobiotechnology and fundamental studies of nanoscale phenomena in science and engineering has opened new opportunities in these areas. As these areas accelerate, there is a need to develop nanoscale patterns and structures via rapid prototyping pathways and with methods accessible to an ever-diverse researcher base without a background in nanofabrication. By establishing the first NanoFrazor in Australia, this project aims to provide new technology for the fabrication of high-resolution nanoscale structures and patterns.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100233
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Characterisation of infrared imaging technologies. This project aims to establish a facility for two-dimensional (2D) infrared sensor array testing and prototyping. Systematic characterisation and prototyping of 2D imaging arrays is vital in showcasing and realising Australia's innovation and research investment in photodetector technologies. This facility will enable research on 2D imaging arrays, such as pixel yield and cross-talk, device reliability physics, failure mechanisms, noise and long ....Characterisation of infrared imaging technologies. This project aims to establish a facility for two-dimensional (2D) infrared sensor array testing and prototyping. Systematic characterisation and prototyping of 2D imaging arrays is vital in showcasing and realising Australia's innovation and research investment in photodetector technologies. This facility will enable research on 2D imaging arrays, such as pixel yield and cross-talk, device reliability physics, failure mechanisms, noise and long-term stability. The facility will demonstrate Australia's innovative imaging technologies, applicable in science, industry, defence and security, attracting interest from both Australian and international industries.Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.