Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using ....A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using optically excited piezo-resistive sensors, and cold femtosecond laser ablation of hard dental tissue. Expected outcomes include a working prototype for laser removal of tooth materials at speeds exceeding dental drills, providing benefits in miniaturized laser devices and ultimately removing pain from dental procedures. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100010
Funder
Australian Research Council
Funding Amount
$928,291.00
Summary
Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical com ....Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical complexity of traditional tools requiring highly specialised personnel. By offering accessible, easy-to-use advanced systems, this project will significantly boost scientific discovery across physics, chemistry, and biology, fostering collaboration and innovation to better understand life at the molecular level.Read moreRead less
Development and investigation of functional solid-state nano-pore membranes. This project aims to develop robust membranes with molecular size pores using atomically thin layers and silicon-based materials. Using state-of-the-art characterisation techniques and computer simulations it seeks to derive a fundamental understanding of the membrane formation processes and pore properties. Expected outcomes include industrially compatible fabrication processes that should enable rapid integration of t ....Development and investigation of functional solid-state nano-pore membranes. This project aims to develop robust membranes with molecular size pores using atomically thin layers and silicon-based materials. Using state-of-the-art characterisation techniques and computer simulations it seeks to derive a fundamental understanding of the membrane formation processes and pore properties. Expected outcomes include industrially compatible fabrication processes that should enable rapid integration of the membranes into advanced device applications as well as enhancing national capabilities for materials characterisation. Significant benefits should result from novel applications of the technologies in the areas of medical- and bio-sensing, filtration, and lab-on-the-chip devices.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100587
Funder
Australian Research Council
Funding Amount
$443,347.00
Summary
A quantum telescope for extremely high-resolution imaging. This project will combine world-leading Australian signal stabilisation technology with recent developments in quantum sensors to demonstrate the world’s first quantum telescope. This project expects to demonstrate that quantum detectors can feasibly link optical telescopes, separated by hundreds of kilometres, to achieve extremely high-resolution imaging. Expected outcomes are the development of technologies that will enable imaging wit ....A quantum telescope for extremely high-resolution imaging. This project will combine world-leading Australian signal stabilisation technology with recent developments in quantum sensors to demonstrate the world’s first quantum telescope. This project expects to demonstrate that quantum detectors can feasibly link optical telescopes, separated by hundreds of kilometres, to achieve extremely high-resolution imaging. Expected outcomes are the development of technologies that will enable imaging with resolution more than 20 times better than any existing telescope. This will provide significant benefits for astronomy, space situational awareness, and defence.Read moreRead less
How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluores ....How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluorescence microscope previously developed that can locate the position of proteins with 2 nanometer resolution. The expected outcomes of this project is a class of biosensor that can continuously monitor protein biomarkers for wearable sensors that provide information on a user’s wellness and nutrition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100964
Funder
Australian Research Council
Funding Amount
$456,354.00
Summary
Precision Rulers for the Visible - Chip Scale Optical Frequency Combs. This project aims to create a photonic chip technology that generates hundreds of coherent laser lines in the visible spectrum from a single chip for accurate sensing, imaging unknown objects and measuring gas emissions. The project expects to introduce this new capability in the current photonic chip technology, which currently only operates with infrared light. The expected outcomes are inexpensive, stable and energy-effici ....Precision Rulers for the Visible - Chip Scale Optical Frequency Combs. This project aims to create a photonic chip technology that generates hundreds of coherent laser lines in the visible spectrum from a single chip for accurate sensing, imaging unknown objects and measuring gas emissions. The project expects to introduce this new capability in the current photonic chip technology, which currently only operates with infrared light. The expected outcomes are inexpensive, stable and energy-efficient devices the size of a fingernail that will enable measurements with unprecedented accuracies. This should allow these devices to be mounted on drones, satellites, and robots, making them attractive for defence, information security, imaging, autonomous vehicle, and sensing applications.Read moreRead less
Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could l ....Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could lead to improved disease management and eradication programs through identification and treatment of drug resistant pathogens in individuals that have the potential to re-infect the community.Read moreRead less
Photoacoustic cellular manipulation: building from the bottom up. In this project we propose an approach for creating complex 3D prints. Whereas current approaches are limited to defining the external geometry, this technology will permit the organization of the internal structure as well, with the potential to do so at the scale of individual cells. Achieving this has important applications in bioprinting human tissues and additive manufacturing. This is based on the manipulation of particles a ....Photoacoustic cellular manipulation: building from the bottom up. In this project we propose an approach for creating complex 3D prints. Whereas current approaches are limited to defining the external geometry, this technology will permit the organization of the internal structure as well, with the potential to do so at the scale of individual cells. Achieving this has important applications in bioprinting human tissues and additive manufacturing. This is based on the manipulation of particles and cells using holographic acoustic fields controlled by patterned light. This is compared to current acoustic patterning approaches are mostly limited to static simple geometric arrangements and lack the flexibility to produce arbitrary, rapidly changing fields that enable the fabrication of complex structures. Read moreRead less
Parallel Lines: Ultra-dense optical systems for extreme data-rates. The project aims to explore methods to significantly expand global internet data rates, by using emerging ultra-dense optical technologies. The project plans to discover how novel existing and emerging tiny photonic chip devices may enable the use of new, unused optical spectral bands, and then enable 1000s of channels to be supported by exploiting newly available parallelism in both wavelength and space. Success in the project ....Parallel Lines: Ultra-dense optical systems for extreme data-rates. The project aims to explore methods to significantly expand global internet data rates, by using emerging ultra-dense optical technologies. The project plans to discover how novel existing and emerging tiny photonic chip devices may enable the use of new, unused optical spectral bands, and then enable 1000s of channels to be supported by exploiting newly available parallelism in both wavelength and space. Success in the project aims may enable speeds of up to 100 times greater than achievable today, in a variety of fibre optic systems. Connectivity is key to our society, so benefits may arise in both future-proofing key Australian data infrastructure, and in providing a roadmap to support exponential capacity growth over the coming decades.Read moreRead less