Advanced microelectronic transistor structures for novel biosensor technology. This international, interdisciplinary team aims to develop an electronic biosensor technology that will significantly advance biomedical research to combat human disease. This is likely to have a major social impact on the community, improve health outcomes and generate substantial economic potential for the pharmaceutical industry. The principal benefit of this research will be the fabrication of electronic devices b ....Advanced microelectronic transistor structures for novel biosensor technology. This international, interdisciplinary team aims to develop an electronic biosensor technology that will significantly advance biomedical research to combat human disease. This is likely to have a major social impact on the community, improve health outcomes and generate substantial economic potential for the pharmaceutical industry. The principal benefit of this research will be the fabrication of electronic devices based on advanced materials, significantly reducing the time, the biological material used and the complexity of assessing human cell function. In addition to improving health through novel biosensor techniques, this technology is expected to lead to the creation of commercially important intellectual property.Read moreRead less
Effective Microfluidic Cell Sorting using Synergistic Acoustic and Optical manipulation. The fluorescence-activated cell sorting technique alone represented a US$860 million market in worldwide diagnostic and life science research devices for 2004. The development of a faster and cheaper device with similar efficacy, as per the objective of this work, has the potential of supplanting immunological methods of cell sorting and thus yield substantial economic returns to the nation. The research act ....Effective Microfluidic Cell Sorting using Synergistic Acoustic and Optical manipulation. The fluorescence-activated cell sorting technique alone represented a US$860 million market in worldwide diagnostic and life science research devices for 2004. The development of a faster and cheaper device with similar efficacy, as per the objective of this work, has the potential of supplanting immunological methods of cell sorting and thus yield substantial economic returns to the nation. The research activities in this project will strengthen Australia's research standing in the fields of microfluidics and lab-in-a-chip technologies. On a broader platform, it will contribute to Australia's high standing in the field of biotechnology.Read moreRead less
Development and application of wearable micro technologies for the assessment of swimming performance and activity. Australia's sporting performance at a national and international level are ingrained in the psyche of everyday Australians. It encourages sporting activity at every level of our society contributing to our well being and the development of tommorrow's athletes.
This research project will develop important tools for the assessment and servicing of our nations elite athletes, includ ....Development and application of wearable micro technologies for the assessment of swimming performance and activity. Australia's sporting performance at a national and international level are ingrained in the psyche of everyday Australians. It encourages sporting activity at every level of our society contributing to our well being and the development of tommorrow's athletes.
This research project will develop important tools for the assessment and servicing of our nations elite athletes, including those in regional areas. These tools will encompass the very latest in wearable technology and allow athletes to be measured under performance conditions rather than in the laboratory.
Assessment of human motion is also desirable as we seek to assess and aid a progressively aging population and a growing epidemic of obesity in our children.Read moreRead less
Micro-patterning of fluoropolymer surfaces for electronic and biomaterials applications. Formation of micro-patterned structures on fluoropolymers including PTFE, FEP and PVDF will be performed using micro-contact printing techniques in combination with surface graft co-polymerisation; an innovative convergence of two emerging technologies. Surface modification and structures formed will be investigated using contact angle measurements and mapping, and surface analytical techniques (XPS and TOFS ....Micro-patterning of fluoropolymer surfaces for electronic and biomaterials applications. Formation of micro-patterned structures on fluoropolymers including PTFE, FEP and PVDF will be performed using micro-contact printing techniques in combination with surface graft co-polymerisation; an innovative convergence of two emerging technologies. Surface modification and structures formed will be investigated using contact angle measurements and mapping, and surface analytical techniques (XPS and TOFSIMS). Processing methodologies will be identified which allow formation of micrometre scale tracks, and selected area deposition of sensor films and reactive biomaterials. Trial device fabrication will be undertaken using conditions and device structures similar to those required for production of diagnostic sensors and arrays, and polymer-based electronic devices.Read moreRead less
Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-sp ....Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-specific results required. Community healthcare will benefit, through better diagnostic capabilities and customized treatment. Australia is well placed to profit further from this research, in view of the growing worldwide demand for more sophisticated, knowledge-based techniques in medicine.Read moreRead less
The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially imp ....The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially important in vascular disease where blood flow and blood vessels are affected by wall irregularities and lesions. The new knowledge generated by this project will have practical importance and, by identifying achievable outcomes, potentially major cost savings, in medical ultrasound.Read moreRead less
Development of a novel flex sensor for use on catheters in medical pressure diagnostic tools. This research project will lead to a significant improvement on the technologies currently available to diagnostic tests of swallowing dysfunctions in children. The proposed technology is much needed and will enable future development of more direct and targeted interventions to assist with feeding based on these measurement techniques. In addition, the knowledge and expertise learned from this project ....Development of a novel flex sensor for use on catheters in medical pressure diagnostic tools. This research project will lead to a significant improvement on the technologies currently available to diagnostic tests of swallowing dysfunctions in children. The proposed technology is much needed and will enable future development of more direct and targeted interventions to assist with feeding based on these measurement techniques. In addition, the knowledge and expertise learned from this project as applied to such a miniature medical device comprises sufficient generic know-how to be useful in developing other biomedical devices. These developments will have a tangible technological impact in a way that will help the Australian biomedical industry be more competitive in the global market.Read moreRead less
Asymmetrically Twisted Structures to form High-Power Rotary Micromotors for In-Vivo Swimming Microrobots. Major surgery is traumatic and risky, but often the only choice for the most serious of diseases that affect older people. In this study, we aim to provide doctors with a means to avoid major surgery and extend the capabilities of doctors to diagnose and treat patients using non- and minimally-invasive procedures: a powerful micromotor carrying its own power supply and a special flagellar pr ....Asymmetrically Twisted Structures to form High-Power Rotary Micromotors for In-Vivo Swimming Microrobots. Major surgery is traumatic and risky, but often the only choice for the most serious of diseases that affect older people. In this study, we aim to provide doctors with a means to avoid major surgery and extend the capabilities of doctors to diagnose and treat patients using non- and minimally-invasive procedures: a powerful micromotor carrying its own power supply and a special flagellar propeller to swim within the vascular and digestive systems of the human body to perform tasks via remote control. We also aim to understand the mechanisms underlying the operation of our motor system and flagellar motion in fluids to assist in the understanding of twisted blade structures and propulsion in fluids on the micro-scale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100134
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral expl ....Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral exploration and improved evaluation of remediation of mine sites, through to the surveillance and sensing needs of customs, defence and national security. In doing so, it will enhance Australia's research profile as one of the world's leaders in the development and use of optoelectronic sensing.Read moreRead less
Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and corr ....Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and correcting for signal loss due to photon interactions in the body and integrated image reconstruction algorithms. This will lead to a new generation of quantitative imaging devices; the new technologies will be directly translatable to clinical imaging systems and will broaden the range of microPET applications in the life sciences.Read moreRead less