Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel ....Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel rapid genotyping methods and developing ultrasensitive real-time DNA detection that will be integrated on a single chip platform to facilitate a small, low cost and reliable test device. The technology will be readily adaptable to areas where prompt access to genomic information is valuable, such as disease diagnosis and risk prediction.Read moreRead less
Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content pos ....Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content possible in diamond glass coatings is unknown, so determining its ultimate performance is difficult. Expected applications include medical diagnostics, non-volatile memories and programmable chips.Read moreRead less
The development and testing of a device to enhance the application of repetitive transcranial magnetic stimulation. This project aims to develop and evaluate a new device designed to substantially enhance the use of transcranial magnetic stimulation, a technology, which is increasingly being applied in the treatment of disorders such as depression, as well as in the study of normal and abnormal brain function.
Industrial Transformation Training Centres - Grant ID: IC160100026
Funder
Australian Research Council
Funding Amount
$3,722,989.00
Summary
ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative m ....ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative medicine; and additive manufactured tools for surgical planning and education. Highly experienced researchers and industry partners with teams of exceptional post-doctoral fellows and doctoral students would drive each technology. Anticipated impacts are that Australia will be a world-leader in additive biomanufacturing, and that the research will change the fields of science, health and biotechnology.Read moreRead less
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Future neural electrodes: probing the electrical activity of nerves using 3D graphene networks. This research aims to develop a totally new type of neural electrode that will for the first time, allow reliable and long-term stimulation and recording. The approach incorporates graphene based biomaterials with tunable electrical and biological properties within supportive three-dimensional cellular microenvironments, greatly enhancing the electrical interactions between cells and the electrode. Th ....Future neural electrodes: probing the electrical activity of nerves using 3D graphene networks. This research aims to develop a totally new type of neural electrode that will for the first time, allow reliable and long-term stimulation and recording. The approach incorporates graphene based biomaterials with tunable electrical and biological properties within supportive three-dimensional cellular microenvironments, greatly enhancing the electrical interactions between cells and the electrode. The electrical properties of nerve cells will be probed using our three-dimensional graphene network, providing insight into the the brain-machine interface. This project is important as it directly addresses the inherent limitations of current electrode designs.Read moreRead less
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100023
Funder
Australian Research Council
Funding Amount
$1,800,000.00
Summary
ARC Training Centre in Biodevices. ARC Training Centre in Biodevices. The Training Centre aims to assist Australian biodevice and diagnostics companies to develop the next generation of innovative and profitable products that address important healthcare needs in our communities. This will be achieved by addressing industry-specific challenges relating to the multidisciplinary nature of design and development in the biodevices and diagnostics sector; technology uptake and transfer to manufacturi ....ARC Training Centre in Biodevices. ARC Training Centre in Biodevices. The Training Centre aims to assist Australian biodevice and diagnostics companies to develop the next generation of innovative and profitable products that address important healthcare needs in our communities. This will be achieved by addressing industry-specific challenges relating to the multidisciplinary nature of design and development in the biodevices and diagnostics sector; technology uptake and transfer to manufacturing; the composition, maturity and size of local firms in the sector; and the development of high-level entrepreneurial skills for innovative industry researchers. The Training Centre will remove barriers to collaboration between universities and industry by delivering exceptional return on research investment.Read moreRead less
Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the ....Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the bladder. Project research into the design of the electrode will focus on providing safe, effective and efficient stimulation of the neosphincter, while ensuring minimal damage to the surrounding tissues and affording straightforward implantation at surgery.Read moreRead less