Seismic wave modelling and inversion for the most general 3-D anisotropic media. Advanced numerical techniques will be developed and applied to simulate the kinematic and dynamic properties of seismic wave propagation in a complex three-dimensional Earth, involving topography, heterogeneity and the most general anisotropy defined by 21 spatially-dependent elastic moduli. We will develop 2D/3D ray-tracing methods for anisotropic traveltime tomography, 2.5D/3D frequency-domain spectral element met ....Seismic wave modelling and inversion for the most general 3-D anisotropic media. Advanced numerical techniques will be developed and applied to simulate the kinematic and dynamic properties of seismic wave propagation in a complex three-dimensional Earth, involving topography, heterogeneity and the most general anisotropy defined by 21 spatially-dependent elastic moduli. We will develop 2D/3D ray-tracing methods for anisotropic traveltime tomography, 2.5D/3D frequency-domain spectral element methods for full waveform inversion of observational data, and make all these techniques applicable for subsurface imaging under various classes of anisotropy in the Earth. Results will be important for petroleum exploration as well as earthquake seismology and probing the structure of the Earth's deep interior.Read moreRead less
Special Research Initiatives - Grant ID: SR0354640
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Young Investigators Network on Next Generation Electronic Devices. This initiative will build an active, dynamic and strongly interdisciplinary network of young Australian scientists (most awarded their Ph.D. after 1985) working on the development of innovative electronic devices - a national research priority area with enormous economic and technological opportunity. The network will enable a nationally coordinated, internationally competitive approach that capitalizes on untapped opportunitie ....Young Investigators Network on Next Generation Electronic Devices. This initiative will build an active, dynamic and strongly interdisciplinary network of young Australian scientists (most awarded their Ph.D. after 1985) working on the development of innovative electronic devices - a national research priority area with enormous economic and technological opportunity. The network will enable a nationally coordinated, internationally competitive approach that capitalizes on untapped opportunities, utilises existing/emerging Australian expertise and develops strong supporting links with similar networks overseas. The initiative will produce a public showcase of Australian strengths and opportunities in this field, and enable stronger collaborations and cooperative logistics management through the development of a dedicated network management website.Read moreRead less
Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpi ....Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.Read moreRead less
Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecule ....Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecules which are present in interstellar ice and dust clouds. The structures and chemistry of such molecules are of importance in understanding the origins of life on this planet.Read moreRead less
Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous syst ....Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system.
(ii) to study the possibility of the formation of biological molecules of life in interstellar regions
(iii) to train graduate students to international standards in the chemistry of proteomics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less