Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radi ....Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radiolabelled compound and a deeper insight into the mode of action will enable development of ligands for positron emission tomography (PET) which will aid in the development of BNC375 as well as other alpha7 modulators.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100139
Funder
Australian Research Council
Funding Amount
$1,240,000.00
Summary
Revitalizing facilities for nuclear magnetic resonance in South Australia. Nuclear magnetic resonance (NMR) spectroscopy is the single most powerful spectroscopic tool for determining molecular structure. Our aim is to upgrade NMR infrastructure available to researchers across South Australia with an integrated and complementary array of state-of-the-art spectrometers to diversify usage across a range of disciplines. Replacement of outdated spectrometers will modernise core NMR facilities along ....Revitalizing facilities for nuclear magnetic resonance in South Australia. Nuclear magnetic resonance (NMR) spectroscopy is the single most powerful spectroscopic tool for determining molecular structure. Our aim is to upgrade NMR infrastructure available to researchers across South Australia with an integrated and complementary array of state-of-the-art spectrometers to diversify usage across a range of disciplines. Replacement of outdated spectrometers will modernise core NMR facilities along with installation of new probes to improve sensitivity and the ability to analyze small sample quantities. Our overall strategy is to maximize capability and minimize duplication, while bringing South Australia's NMR capabilities up to a national and international standard. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100203
Funder
Australian Research Council
Funding Amount
$860,000.00
Summary
South Australian High Throughput Screening Facility. High throughput screening facility: The project aims to establish a high throughput screening facility (including a confocal cell imager and surface plasmon resonance facility) to provide researchers with access to equipment that will enable cultured cells to be screened with large libraries of chemicals or nucleic acids (over-expression, RNA interference, microRNAs, long non-coding RNAs). Cellular responses can be monitored by biochemical ass ....South Australian High Throughput Screening Facility. High throughput screening facility: The project aims to establish a high throughput screening facility (including a confocal cell imager and surface plasmon resonance facility) to provide researchers with access to equipment that will enable cultured cells to be screened with large libraries of chemicals or nucleic acids (over-expression, RNA interference, microRNAs, long non-coding RNAs). Cellular responses can be monitored by biochemical assays or detailed imaging. These screens will enable dissection of biological pathways and discovery of genes that regulate fundamental biological processes. Models will include microbial, plant and mammalian cells. The facility will also study inter-molecular interactions. Fragment-based lead discovery screens will generate novel reagents for studying protein and membrane biology.Read moreRead less