Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
High-brightness wavelength tuneable lasers for quantum science. This project aims to establish the capability to manufacture application-specific semiconductor lasers. The project will use existing facilities in Australia to enhance our world-leading quantum science research, and establish a viable export-dominated high-tech manufacturing business. Semiconductor lasers are a critical enabling technology for many scientific applications, particularly for quantum science including quantum computin ....High-brightness wavelength tuneable lasers for quantum science. This project aims to establish the capability to manufacture application-specific semiconductor lasers. The project will use existing facilities in Australia to enhance our world-leading quantum science research, and establish a viable export-dominated high-tech manufacturing business. Semiconductor lasers are a critical enabling technology for many scientific applications, particularly for quantum science including quantum computing and quantum sensing. This project is expected to enable the establishment of a high-tech manufacturing capability to support Australia's leading role in quantum science, and expand our scientific instrumentation exports to new and rapidly developing applications such as magnetic sensing and imaging at nanoscale, quantum communication and computation.Read moreRead less
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
An atom-scale fabrication technique for diamond quantum microprocessors. This project aims to develop an atomically-precise fabrication technique for the production of diamond quantum microprocessors through the pursuit of a novel bottom-up approach. This project expects to create significant new knowledge and capability in precision diamond growth, surface chemistry, electronics and characterisation, establish a long-term strategic partnership between Quantum Brilliance and the participating or ....An atom-scale fabrication technique for diamond quantum microprocessors. This project aims to develop an atomically-precise fabrication technique for the production of diamond quantum microprocessors through the pursuit of a novel bottom-up approach. This project expects to create significant new knowledge and capability in precision diamond growth, surface chemistry, electronics and characterisation, establish a long-term strategic partnership between Quantum Brilliance and the participating organisations, and enable the realisation of high-performance quantum microprocessors. These outcomes will potentially deliver Australia and Quantum Brilliance a profound advantage in quantum computing, thereby securing their positions in the emerging global quantum market and the associated economic and security benefits.Read moreRead less
Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will explo ....Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.Read moreRead less
Improving methods of grading, transferring and facilitating translation of knowledge in population health. This project will develop methods by which research in population health can be better used by policy makers. It will develop a grading system to assist research consumers to work out the best evidence. Interviews and surveys of policy makers will be conducted to work out how to optimise the way the best evidence can be used in practice.
Testing co-evolutionary processes driving venom diversity in tiger snakes. Testing co-evolutionary processes driving venom diversity in tiger snakes. This project aims to examine the geographic variation amongst tiger snakes in anatomy, ecology, and life history traits, and the relationship of these factors to venom toxins and production; and to evaluate the true pharmacological potential of tiger snake venom. This project will investigate the role of venom adaptation in long-term animal evoluti ....Testing co-evolutionary processes driving venom diversity in tiger snakes. Testing co-evolutionary processes driving venom diversity in tiger snakes. This project aims to examine the geographic variation amongst tiger snakes in anatomy, ecology, and life history traits, and the relationship of these factors to venom toxins and production; and to evaluate the true pharmacological potential of tiger snake venom. This project will investigate the role of venom adaptation in long-term animal evolution, by identifying rare venom transcripts involved in providing evolutionary potential for adaptation to environmental change. This is essential as continuing climatic and human-induced alteration of our environment affects southern Australia where many people live, work and interact with native wildlife. Anticipated outcomes are maximizing venom harvests and enhanced snakebite treatment capacity.Read moreRead less