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Enhancing sunscreen DNA and photo-ageing protection. Skin damage from UV exposure is costly for individuals and the community, particularly in Australia, where the population has predominantly fair skin. While public campaigns to persuade the population to use sun protection and avoidance have been useful, this project will be the first to extend this approach to deliver a way to reduce sun damage from any UV exposure that does nevertheless occur, by incorporating the active agents into topical ....Enhancing sunscreen DNA and photo-ageing protection. Skin damage from UV exposure is costly for individuals and the community, particularly in Australia, where the population has predominantly fair skin. While public campaigns to persuade the population to use sun protection and avoidance have been useful, this project will be the first to extend this approach to deliver a way to reduce sun damage from any UV exposure that does nevertheless occur, by incorporating the active agents into topical sunscreens or creams for after-sun use. The project will also build infrastructure for translational research on photo-damage, combining world-class facilities for this research with advanced formulation and manufacturing operations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775726
Funder
Australian Research Council
Funding Amount
$306,270.00
Summary
Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizati ....Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizations and industry with state-of-the-art genomic data storage and analysis capability, which will permit both public and proprietary access, and accelerate Australian research and development in genetic medicine, pharmaceuticals, animal breeding and biodiversity.Read moreRead less
Development of class-leading bioluminescence resonance energy transfer technologies for real-time monitoring of molecular interactions. The purpose of this project is to develop improved technologies for identifying and developing pharmaceuticals with fewer side effects. The expected outcome is the development of technologies that provide a level of sensitivity and data quality that enables adoption by the biotechnology and pharmaceutical industries.
Application of direct protein transduction of Stem Cell Factors to reprogram mouse and human somatic cells into pluripotent stem cells. This project aims to generate embryonic stem cell-like cells from human somatic cells, using direct protein transduction of defined factors, rather than through retroviral delivery. This will bring stem cell application closer to a therapeutic setting. The cells produced will be free from genetic modification and will yield products for patient-specific cell-ba ....Application of direct protein transduction of Stem Cell Factors to reprogram mouse and human somatic cells into pluripotent stem cells. This project aims to generate embryonic stem cell-like cells from human somatic cells, using direct protein transduction of defined factors, rather than through retroviral delivery. This will bring stem cell application closer to a therapeutic setting. The cells produced will be free from genetic modification and will yield products for patient-specific cell-based therapies that will be accepted by recipients without the need for immunosuppressant therapy. This development is expected to revolutionize the current approach to treating disease and injury, and is likely to result in the generation of highly marketable potent cell reprogramming therapeutics.Read moreRead less
Bacterial detection and infection control using tethered membranes. This project will develop a rapid diagnostic tool to detect live bacteria, which will subsequently reduce risk of infection, increase efficiencies in patient care and hospital management, and produce savings in health care budgets. It also has the potential to save lives through addressing the serious and growing problem of antibiotic resistance.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775758
Funder
Australian Research Council
Funding Amount
$587,000.00
Summary
A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By su ....A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By supporting this wide range of well funded researh, the mass spectrometry facility will support the emerging Biotechnology sector and National Research Priorities.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
Understanding surface acoustic wave atomisation for pulmonary delivery of drug aerosols in personalised medicine. Delivering drugs via the lung is hampered by development costs and inadequate technology. This project will provide an understanding of atomisation in our unique respire system, enabling not only the delivery of new vaccines and drugs but also the rapid and cost effective development of new disease treatments personalised to the patient.
Transforming drug screening technology. Transforming drug screening technology. This project aims to develop field-leading microchip technology, including the ability to measure contraction of micro-tissues on a chip. Micro-chip technology is in its infancy for use in drug discovery. However, interest in development and applications in Pharma and Biotech industries is immense. The project is intended to take proof-of-concept studies through to the “working model” stage and then to a level of ind ....Transforming drug screening technology. Transforming drug screening technology. This project aims to develop field-leading microchip technology, including the ability to measure contraction of micro-tissues on a chip. Micro-chip technology is in its infancy for use in drug discovery. However, interest in development and applications in Pharma and Biotech industries is immense. The project is intended to take proof-of-concept studies through to the “working model” stage and then to a level of industry-utility, focussing on predictive value, reproducibility and throughput. Successful development of the drug discovery micro-fluidics chip is expected to improve efficiency, reduce the costs and the use of experimental animals.Read moreRead less
Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the poten ....Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the potential to shift disease diagnosis and monitoring closer to the point of care. Expected outcomes include the development of synthetic diamond-based microneedles for the potential to greatly benefit society through improved and affordable healthcare and the development of new high-tech industries.Read moreRead less