Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775726
Funder
Australian Research Council
Funding Amount
$306,270.00
Summary
Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizati ....Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizations and industry with state-of-the-art genomic data storage and analysis capability, which will permit both public and proprietary access, and accelerate Australian research and development in genetic medicine, pharmaceuticals, animal breeding and biodiversity.Read moreRead less
Application of direct protein transduction of Stem Cell Factors to reprogram mouse and human somatic cells into pluripotent stem cells. This project aims to generate embryonic stem cell-like cells from human somatic cells, using direct protein transduction of defined factors, rather than through retroviral delivery. This will bring stem cell application closer to a therapeutic setting. The cells produced will be free from genetic modification and will yield products for patient-specific cell-ba ....Application of direct protein transduction of Stem Cell Factors to reprogram mouse and human somatic cells into pluripotent stem cells. This project aims to generate embryonic stem cell-like cells from human somatic cells, using direct protein transduction of defined factors, rather than through retroviral delivery. This will bring stem cell application closer to a therapeutic setting. The cells produced will be free from genetic modification and will yield products for patient-specific cell-based therapies that will be accepted by recipients without the need for immunosuppressant therapy. This development is expected to revolutionize the current approach to treating disease and injury, and is likely to result in the generation of highly marketable potent cell reprogramming therapeutics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775758
Funder
Australian Research Council
Funding Amount
$587,000.00
Summary
A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By su ....A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By supporting this wide range of well funded researh, the mass spectrometry facility will support the emerging Biotechnology sector and National Research Priorities.Read moreRead less
Transduction of neuronal signals by brain macroglial cells: implications for neuronal function. Study of mechanisms regulating brain cell (neuron and glial) communication is essential for understanding of normal brain function and transformations that occur in neurodegenerative states and age-related disorders. Mechanisms underlying neuron-glia communication are not well understood. By combining cell physiology, digital imaging technologies, and genetically designed and delivered molecules we w ....Transduction of neuronal signals by brain macroglial cells: implications for neuronal function. Study of mechanisms regulating brain cell (neuron and glial) communication is essential for understanding of normal brain function and transformations that occur in neurodegenerative states and age-related disorders. Mechanisms underlying neuron-glia communication are not well understood. By combining cell physiology, digital imaging technologies, and genetically designed and delivered molecules we will enhance our understanding of this brain cell communication and critical roles played by intracellular calcium. This will enhance international competitiveness of Australian biological research and provide novel insight of glial function in neurodegeneration and potential for specific therapeutic intervention in disease.Read moreRead less
Fabrication of robust nanoscale optical biosensors using the novel spinning disc reactor technology. Spinning Disc Reactor (SDR) technology is new to Australia and will have wide ranging applications in nano-technology, and is destined to attract significant industrial interest beyond the proposed application in nano-scale biosensors. SDR is based on continuous flow and is more benign (less chemical waste) than traditional batch technology with a smaller footprint and significantly reduced capit ....Fabrication of robust nanoscale optical biosensors using the novel spinning disc reactor technology. Spinning Disc Reactor (SDR) technology is new to Australia and will have wide ranging applications in nano-technology, and is destined to attract significant industrial interest beyond the proposed application in nano-scale biosensors. SDR is based on continuous flow and is more benign (less chemical waste) than traditional batch technology with a smaller footprint and significantly reduced capital outlay. The emergence of SDR technology will revolutionize the practice of nano-engineering leading to miniaturization of devices, advances in information technologies and intelligent systems, and the revolution in medical science. The exciting research will enhance public opinion towards science.Read moreRead less
Anticancer Agents from Australian Marine Biodiversity. This project aims to initiate a proof of concept research collaboration in order to detect, isolate, characterise, identify and evaluate new marine anticancer drugs. This will be achieved through screening Australian marine biodiversity for the ability to inhibit key processes in tumor cell physiology. Significant outcomes from the project will not only be targets that yield new anticancer agents, but also the participation of Australian r ....Anticancer Agents from Australian Marine Biodiversity. This project aims to initiate a proof of concept research collaboration in order to detect, isolate, characterise, identify and evaluate new marine anticancer drugs. This will be achieved through screening Australian marine biodiversity for the ability to inhibit key processes in tumor cell physiology. Significant outcomes from the project will not only be targets that yield new anticancer agents, but also the participation of Australian researchers in the environmentally sustainable exploration, discovery and development of next generation anticancer drugs from Australia's unique marine biodiversity. Read moreRead less
Chemical Insights to Peptide Helix-Sheet-Nanofibre Equilibria. We live in an ageing community that is experiencing exponential growth in neurological diseases that require full time carers and place significant burdens on our health system. Many such diseases are caused by (apparently) abnormal folding of proteins that aggregate into insoluble materials. The chemistry behind these processes is not sufficiently well understood to know precisely why the diseases are caused and how they might be tr ....Chemical Insights to Peptide Helix-Sheet-Nanofibre Equilibria. We live in an ageing community that is experiencing exponential growth in neurological diseases that require full time carers and place significant burdens on our health system. Many such diseases are caused by (apparently) abnormal folding of proteins that aggregate into insoluble materials. The chemistry behind these processes is not sufficiently well understood to know precisely why the diseases are caused and how they might be treated. This project will use new strategies to control peptide folding, provide important new information relevant to understanding such processes/diseases, and teach us how to engineer important new biomaterials that can advance nanotechnology. Read moreRead less
Characterisation of snake venom components and screening venom for bioactive compounds. Animal venoms are a rich source of bioactive compounds. This project will separate and characterise the protein-containing components of the North Queensland taipan. It will also involve constructing a cDNA library from mRNA isolated from the venom glands of the same snake and individual clones will be isolated and sequenced. Individual snake venom components, purified either from whole snake venom or synthes ....Characterisation of snake venom components and screening venom for bioactive compounds. Animal venoms are a rich source of bioactive compounds. This project will separate and characterise the protein-containing components of the North Queensland taipan. It will also involve constructing a cDNA library from mRNA isolated from the venom glands of the same snake and individual clones will be isolated and sequenced. Individual snake venom components, purified either from whole snake venom or synthesised via in vivo expression, will be tested in a variety of rapid throughput screening assays to identify specific bioactivities. This project will train a post graduate scientist in methods involved in the discovery of novel bioactive compounds.Read moreRead less
Special Research Initiatives - Grant ID: SR0354630
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Fluorescence Applications in Biotechnology and Life Sciences. The Network in Fluorescence applications in biotechnology and life sciences will coordinate a research program relating to applications of fluorescence whose proper resolution requires a high degree of interaction between biology, physics, chemistry, bioengineering and medicine. These would be applied to industrially relevant problems in areas such as public health, biotechnology, safety of foods, chemical biology and environmental mo ....Fluorescence Applications in Biotechnology and Life Sciences. The Network in Fluorescence applications in biotechnology and life sciences will coordinate a research program relating to applications of fluorescence whose proper resolution requires a high degree of interaction between biology, physics, chemistry, bioengineering and medicine. These would be applied to industrially relevant problems in areas such as public health, biotechnology, safety of foods, chemical biology and environmental monitoring. Approaches such as highly selective fluorescent labelling of targets using appropriate immunological and molecular techniques and purpose-engineered fluorochromes accompanied by the development of specialised instrumentation will capitalise on the multi-disciplinary research strengths in Australia and lead towards tangible industrial outcomes.
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Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these so ....Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these societal needs and provide a new way to purify these important molecules. National and community benefits will accrue from this scientific innovation and from its application, which is expected to provide more efficient manufacturing opportunities for key biotechnology industries.Read moreRead less