A New Platform for Developing a Compound Against Herpes Simplex Virus. This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability ....A New Platform for Developing a Compound Against Herpes Simplex Virus. This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability of current drugs and thus significantly shorten the recurrence period. Such new drugs may have broad applicability.Read moreRead less
Developing and testing a novel biological reduction cell to remediate heavy metal and acid-containing industrial and mine leachates. Echo Remediation Ltd. has a new reduction cell that uses sulfur and bacteria to remove heavy metals and acidity from mine leachates, but development is now required to make it viable. The project aims to optimise the process using molecular approaches to study the effects of operating conditions on the bacterial communities. As part of the investigation, active iro ....Developing and testing a novel biological reduction cell to remediate heavy metal and acid-containing industrial and mine leachates. Echo Remediation Ltd. has a new reduction cell that uses sulfur and bacteria to remove heavy metals and acidity from mine leachates, but development is now required to make it viable. The project aims to optimise the process using molecular approaches to study the effects of operating conditions on the bacterial communities. As part of the investigation, active iron reducers will be selected and introduced to the cell (in conjunction with chemical amendments) and their colonization monitored. The new technology once developed has the potential to be used at mine sites in Australia and overseas and its employment offers a sustainable, biological "green" approach to mine waste remediation.Read moreRead less
Info-chemicals for the environmentally sustainable management of autumn gum moth and scarab beetle pests of bluegum plantations. Insect pest control in Australian bluegum plantations currently relies on insecticides. Insecticides are incompatible with maintaining populations of native beneficial insects and achieving biotic regulation of pest populations. Info-chemicals offer ways of disrupting pest populations that are benign to beneficials because they only interfere with the responses of the ....Info-chemicals for the environmentally sustainable management of autumn gum moth and scarab beetle pests of bluegum plantations. Insect pest control in Australian bluegum plantations currently relies on insecticides. Insecticides are incompatible with maintaining populations of native beneficial insects and achieving biotic regulation of pest populations. Info-chemicals offer ways of disrupting pest populations that are benign to beneficials because they only interfere with the responses of the target insect. This project will pioneer the development of sex pheromone-based technologies for managing autumn gum moth and reveal potential applications of info-chemicals for managing scarab beetles. Application of info-chemical solutions to plantation pests will improve public perception of the industry and assist with forestry standard certification.Read moreRead less
Seafood safety: high throughput diagnostics for ciguatoxin risk assessment. This project aims to develop a novel, high throughput platform for rapidly assessing ciguatoxins. Species of the marine microalgae Gambierdiscus produce ciguatoxins, which accumulate in fish through marine food chains to cause the often debilitating human illness called ciguatera fish poisoning. Ciiguatera fish poisoning is a growing and substantial risk for the $2.2 billion Australian commercial fishing industry. This s ....Seafood safety: high throughput diagnostics for ciguatoxin risk assessment. This project aims to develop a novel, high throughput platform for rapidly assessing ciguatoxins. Species of the marine microalgae Gambierdiscus produce ciguatoxins, which accumulate in fish through marine food chains to cause the often debilitating human illness called ciguatera fish poisoning. Ciiguatera fish poisoning is a growing and substantial risk for the $2.2 billion Australian commercial fishing industry. This serious illness is increasingly impacting more southerly areas of Australia due to environmental changes. The outcomes of this project include new knowledge of the risk of ciguatoxins at Australian 'hot spot' sites, extensively field tested methods for detecting Gambierdiscus and ciguatoxins in situ and key data to inform policy to safeguard the seafood industry and consumers.
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Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed g ....Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed global public response to challenges posed by genome editing. Research will test the effects of the deliberative documentary on viewers, examining benefits of communicating complex issues via the work of the GCA. Other benefits include improving public trust in governance and advancing the Australian film industry.
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The neural effects of torture. Torture affects millions of people and causes much long-term psychological harm. This project aims to identify the effects that torture has on the brain by studying torture survivors in the context of a range of brain imaging technologies that will lead to development of a model of the neural effects of torture to guide better treatments.
Development of an immune enhancing vaccine to protect Tasmanian devils against a contagious cancer. The iconic Tasmanian devil is threatened with extinction from a uniformly fatal transmissible facial cancer. Our team has shown in proof of concept that the cancer cells can be recognised by the devil immune system. This project will develop and test a vaccine against the tumour, which will ultimately protect devils in the wild.