Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775726
Funder
Australian Research Council
Funding Amount
$306,270.00
Summary
Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizati ....Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizations and industry with state-of-the-art genomic data storage and analysis capability, which will permit both public and proprietary access, and accelerate Australian research and development in genetic medicine, pharmaceuticals, animal breeding and biodiversity.Read moreRead less
Bioreactors for manufacture of human platelets. Blood cell transfusion is a critical part of medicine that is supported by volunteer donors. Unfortunately, the demand for blood cells for transfusion far outstrips supply and therefore new strategies are required for manufacture of blood cells. This project will lead to the development of technology for manufacture of human platelets from stem cells. The systems devised will be applicable to a broad range of other blood cell types.
New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.
Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic det ....Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic detector. The need for rapid, non-contact screening devices to detect and identify illicit drugs and precursors entering Australia has never been greater. Law enforcement agencies should directly benefit from the capability to more rapidly screen people and cargo, improving efficiency of illicit drug detection and protection of our borders.Read moreRead less
Identification Of A Y-chromosome Marker In Atlantic Salmon (extension To FRDC 95/80)
Funder
Fisheries Research and Development Corporation
Funding Amount
$113,479.00
Summary
Genetic variation The results we have obtained in the current project are encouraging for SALTAS, as they confirm the earlier allozyme results of little loss of genetic variation. However, the results are also suggestive of a potential long term trend in loss of genetic variation. A sample collected and analysed in January 1997 (1993 year-class parents) would provide evidence to substantiate this trend or indicate whether the current results were a sampling artifact. The analysis of a 1997 ....Genetic variation The results we have obtained in the current project are encouraging for SALTAS, as they confirm the earlier allozyme results of little loss of genetic variation. However, the results are also suggestive of a potential long term trend in loss of genetic variation. A sample collected and analysed in January 1997 (1993 year-class parents) would provide evidence to substantiate this trend or indicate whether the current results were a sampling artifact. The analysis of a 1997 sample would be the second of a proposed regular 4 to 5 year assessment of the status of the Tasmanian stock, and would help to describe the nature and speed of any long term trends.
SALTAS, as the principal Atlantic salmon hatchery in Australia, has a long term requirement to maintain industry and investor confidence in their product, and the ability to confirm the reliability of its breeding practices is important for the sustainability of the industry.
Loss of genetic variation in a cultured population will provide an early indicator of potential inbreeding, which could have grave consequences as deleterious recessive genes are exposed and stocks lose vigour dependent on genetic variance. Any loss of genetic variation in Tasmanian Atlantic salmon could be difficult or impossible to recover due to the restrictions on importation of new broodstock.
Y-chromosome marker A number of molecular genetic techniques for trait or marker screening have been developed since the original proposal was submitted. We propose to apply some of these new techniques to the screening of Atlantic salmon DNA for a potential Y-chromosome marker. These approaches will greatly increase our chances of finding such a marker.
The new techniques we propose include: Representational Difference Analysis (RDA); PCR-Select cDNA Subtraction Technique; the application of other modified subtractive hybridization and differential display techniques that have proved useful in other species; AFLP (amplified fragment polymorphism) technique; and the application of a number of commercial RAPD (random amplified polymorphic DNA) primers.
We have also established contact, and will collaborate during the proposed project extension, with workers who have a Y-chromosome marker for brook trout and arctic char, and other workers in this field working with other teleosts.
We believe that a continuation of the current project (95/80) is the best approach to further tackle this Y-chromosome marker issue. It will allow us to best utilise the expertise and momentum we have established on this problem, rather than completed our current objectives and then revisit this issue in a year or two.
If we are successful in locating a Y-chromosome marker either during the remainder of the current schedule or early in the 1997 grant extension, resources will then be directed to isolate and further characterize that marker. Objectives: 1. To locate a Y-chromosome marker in Atlantic salmon by applying a range of molecular genetic techniques. 2. To establish the rate of change in genetic variation in Tasmanian Atlantic salmon by comparing the genetic (microsatellite and allozyme) variation expressed in progeny from 1993 year-class parents with that present in 1989 year-class parents and the parental Nova Scotia population. Read moreRead less
Application Of ELISA/PCR Tests Developed In Japan To The Detection Of A Barramundi Picorna-like Virus In Australia
Funder
Fisheries Research and Development Corporation
Funding Amount
$9,812.00
Summary
Objectives: 1. Using techniques developed in Japan for the detection of a virus lethal to striped jack and a very similar one that occurs in barramundi, examine the various material from Lates calcarifer 2. Objectives as stated in B4 of the application.
Stock Identification And Discrimination Of Mulloway In Australian Waters
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Investigate population structure of mulloway, Argyrosomus hololepidotus, to determine whether mulloway in Australian waters belong to one large inter-breeding population throughout their range or whether 2 or more separate stocks exist.
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less