Vaccination of poultry infected with multiple Salmonella serovars. Salmonella is a zoonotic, foodborne pathogen found on eggs and poultry meat. It is the second largest cause of human gastrointestinal disease, thus, reduction of Salmonella on poultry farms is paramount to public health. This project aims to evaluate the long-term efficacy of a commercial Salmonella Typhimurium vaccine against multiple serotypes, including the emerging Salmonella Enteritidis. This project will generate new knowle ....Vaccination of poultry infected with multiple Salmonella serovars. Salmonella is a zoonotic, foodborne pathogen found on eggs and poultry meat. It is the second largest cause of human gastrointestinal disease, thus, reduction of Salmonella on poultry farms is paramount to public health. This project aims to evaluate the long-term efficacy of a commercial Salmonella Typhimurium vaccine against multiple serotypes, including the emerging Salmonella Enteritidis. This project will generate new knowledge in avian immunology using an innovative approach to evaluate the host response to multi-serovar infection. Outcomes of this project will future proof the Australian poultry industry against exotic Salmonella serotypes benefitting the industry by significantly reducing risks of future outbreaks and economic loss.Read moreRead less
Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the poten ....Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the potential to shift disease diagnosis and monitoring closer to the point of care. Expected outcomes include the development of synthetic diamond-based microneedles for the potential to greatly benefit society through improved and affordable healthcare and the development of new high-tech industries.Read moreRead less
Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead ....Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead to significant benefits, including high impact publications, additional collaborations with industrial partner Botanix, and a new class of antibiotics to overcome antibiotic resistance.Read moreRead less
A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using ....A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using optically excited piezo-resistive sensors, and cold femtosecond laser ablation of hard dental tissue. Expected outcomes include a working prototype for laser removal of tooth materials at speeds exceeding dental drills, providing benefits in miniaturized laser devices and ultimately removing pain from dental procedures. Read moreRead less
Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and ....Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and joint estimation of physiological and metabolic organ activity. These advances will create innovative imaging technologies for advanced biomedical imaging research with a particular emphasis in healthy ageing.
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Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid iso ....Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid isomers. Resolution of lipid isomers using this instrumentation will afford researchers a first glimpse of isomer-resolved images that will be used to visualise tissue-specific changes resulting from underlying chemical, physical or metabolic processes; changes that are currently invisible to contemporary imaging technologies.Read moreRead less
Breakthrough technologies in implantable bionics. This project aims to introduce revolutionary changes in implantable bionics via miniaturisation, automation and improved reliability and generating new knowledge by leveraging recent advances in laser processes. Expected outcomes include innovative hybrid thin-film/thick-film electrode arrays with more channels and charge-carrying capacity for neuromodulation; novel glass interfaces that facilitate deeply-miniaturised hermetic packages; and failu ....Breakthrough technologies in implantable bionics. This project aims to introduce revolutionary changes in implantable bionics via miniaturisation, automation and improved reliability and generating new knowledge by leveraging recent advances in laser processes. Expected outcomes include innovative hybrid thin-film/thick-film electrode arrays with more channels and charge-carrying capacity for neuromodulation; novel glass interfaces that facilitate deeply-miniaturised hermetic packages; and failure analysis to ensure study aims result in new processes that are as or more reliable than the current state-of-the-art. This work will create new and novel manufacturing processes, and trains the next generation of innovators equipped with the tools to advance implantable bionics into the future.Read moreRead less
The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum ....The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum performance, delivering typically less than 20% of the loaded dose to the target site, the lungs. The new fundamental knowledge resulting from this research will enable the engineering of a high-efficiency groundbreaking DPI, with the potential to be fully adaptive user-specific benefiting millions of Australians. Read moreRead less
High-fidelity, long lasting, single-neuron brain machine interfaces. The ability to conduct stable, high resolution recording and stimulation within the brain is critically important to the development of technologies that interface electronics with the human body. Devices that interface directly with the brain are increasingly important in brain research, medical monitoring, treatment of neurological diseases or the enormous increase in brain-machine interface technologies. Carbon Cybernetics h ....High-fidelity, long lasting, single-neuron brain machine interfaces. The ability to conduct stable, high resolution recording and stimulation within the brain is critically important to the development of technologies that interface electronics with the human body. Devices that interface directly with the brain are increasingly important in brain research, medical monitoring, treatment of neurological diseases or the enormous increase in brain-machine interface technologies. Carbon Cybernetics have developed a high-density neural recording and stimulation array that employs fine carbon fibres as the electrode material. We aim to show that this array can record from the brain indefinitely, without loosing signal quality, and the same array can be used to stimulate the brain to recreate memories or sensations.Read moreRead less
Understanding production and application of alpha emitting radionuclides. This project aims to develop new materials to improve the efficiency of production of radionuclides, as well as tools to improve our understanding of isotope decay products to to improve efficiency of delivery. High performance polymers will be evaluated to establish optimal design properties for enhanced radionuclide collection from novel generators of isotopic lead (Pb-212), and new methods will be developed to improve u ....Understanding production and application of alpha emitting radionuclides. This project aims to develop new materials to improve the efficiency of production of radionuclides, as well as tools to improve our understanding of isotope decay products to to improve efficiency of delivery. High performance polymers will be evaluated to establish optimal design properties for enhanced radionuclide collection from novel generators of isotopic lead (Pb-212), and new methods will be developed to improve understanding of isotope product stability. Anticipated outcomes will provide greater production and utility of radioisotopes in radiopharmaceuticals, while building strong ties with partner AdvanCell Isotopes. This could improve manufacture of radionuclides, expanding capability and applications in radiopharmaceuticals.Read moreRead less