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Reduction of risk in exploration for petroleum liquids. Australia has an urgent need to establish additional reserves of crude oil. A feature of petroleum exploration in recent decades has been discovery of vast reserves of natural gas but an inability to replace our diminishing reserves of crude oil. Clearly new technology is required to enhance our capability to recognise crude oil-prone rather than gas-prone source rocks. The proposed project will establish the fundamental geochemical pro ....Reduction of risk in exploration for petroleum liquids. Australia has an urgent need to establish additional reserves of crude oil. A feature of petroleum exploration in recent decades has been discovery of vast reserves of natural gas but an inability to replace our diminishing reserves of crude oil. Clearly new technology is required to enhance our capability to recognise crude oil-prone rather than gas-prone source rocks. The proposed project will establish the fundamental geochemical processes that will support the potential exploration techniques, developed with Woodside Energy Limited support.Read moreRead less
Guarding and evolving the genome: interactions between DNA-repair enzymes and damaged DNA. The application of structural biology techniques to the area of DNA repair allows us to understand the full implications linking genes and proteins to the molecular mechanisms of diseases such as cancer and hereditory conditions. Studies in this highly internationally competitive area are already established in the Bond laboratory, which has recently relocated to Australia. The use of forward-thinking stru ....Guarding and evolving the genome: interactions between DNA-repair enzymes and damaged DNA. The application of structural biology techniques to the area of DNA repair allows us to understand the full implications linking genes and proteins to the molecular mechanisms of diseases such as cancer and hereditory conditions. Studies in this highly internationally competitive area are already established in the Bond laboratory, which has recently relocated to Australia. The use of forward-thinking structural biology approaches to solve difficult technical problems will foster collaborations within Australia and with leading laboratories abroad, providing excellent up-to-date research training for students and postdoctoral researchers.
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Development of Dry Coated Pigment Particles: Durability and Dispersion. Tiwest is the only business in the world that mines, separates, refines and manufactures titanium dioxide products in one region. Tiwest has a major impact on the Western Australian economy with more than 700 full time and contract jobs, export earnings of $400M (in 2004) and regular incomes for an estimated 500 businesses. The current wet pigment particle coating process, to ensure ease of handling and longevity, is a major ....Development of Dry Coated Pigment Particles: Durability and Dispersion. Tiwest is the only business in the world that mines, separates, refines and manufactures titanium dioxide products in one region. Tiwest has a major impact on the Western Australian economy with more than 700 full time and contract jobs, export earnings of $400M (in 2004) and regular incomes for an estimated 500 businesses. The current wet pigment particle coating process, to ensure ease of handling and longevity, is a major cost. An optimised pigment dry-coating process would ensure Tiwest's competitiveness through reduced processing costs and improved performance. This development has the potential to increase Tiwest's profitability by 10%.Read moreRead less
Inequality, Trade, and Technology. This project aims to improve our understanding of the causes of rising income inequality in the world economy and in Australia since the early 1980s. We focus on the increasing building costs and imports of machinery as significant contributors to the increasing inequality. We hypothesize 1) that the increasing costs of buildings have reduced the demand for workers that are complementary to non-residential building capital; thus, reducing real wages; and 2) tha ....Inequality, Trade, and Technology. This project aims to improve our understanding of the causes of rising income inequality in the world economy and in Australia since the early 1980s. We focus on the increasing building costs and imports of machinery as significant contributors to the increasing inequality. We hypothesize 1) that the increasing costs of buildings have reduced the demand for workers that are complementary to non-residential building capital; thus, reducing real wages; and 2) that the marked increase in imports of machinery since the 1960s has reduced the demand for unskilled labour and widened the employment and wage gap between skilled and unskilled labour. Both factors may have driven the increasing inequality in Australia.
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Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate fa ....Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate factors that shape inequality and its relation to growth. This knowledge should enable Australian governments to reduce inequality and benefit economic growth, thereby reducing disadvantage and building stronger, more resilient communities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100978
Funder
Australian Research Council
Funding Amount
$406,818.00
Summary
A new Iron Age! Making Iron complexes fit for C-C cross-coupling catalysis. This project aims to develop new iron catalysts as alternatives to the expensive and increasingly rare noble metals currently used in C-C bond forming reactions, the most important single-step in the fine-chemicals sector.
This project expects to create a flexible yet robust framework by introducing a hemilabile ligand into the backbone of the iron complex to control the number of vacant coordination sites.
Expected outc ....A new Iron Age! Making Iron complexes fit for C-C cross-coupling catalysis. This project aims to develop new iron catalysts as alternatives to the expensive and increasingly rare noble metals currently used in C-C bond forming reactions, the most important single-step in the fine-chemicals sector.
This project expects to create a flexible yet robust framework by introducing a hemilabile ligand into the backbone of the iron complex to control the number of vacant coordination sites.
Expected outcomes of this project are 1) iron complexes able to catalyse biaryl couplings from sustainable substrates and 2) knowledge on structure-property relationships of iron-based catalytic processes.
Australia will benefit by applying its own resources and help preserving the valuable noble metals for processes relying on them.Read moreRead less
Melanoma Mutation Profiling For Personalised Treatment
Funder
National Health and Medical Research Council
Funding Amount
$571,191.00
Summary
Melanoma is an aggressive skin cancer, and the leading cause of skin cancer related deaths. Disease spread is difficult to detect and extremely difficult to cure. This bleak clinical outcome is changing with the development of personalised therapies which include small molecule inhibitors to treat metastatic melanoma. Here we seek to identify the spectrum of mutations in patient tumours and circulating tumour cells for advanced personalised treatment.
Enhanced metal recovery from a modified Caron leach of mixed nickel-cobalt intermediate concentrate. Nickel metal production from lateritic deposits involves dissolution in acid followed by purification and selective alkaline precipitation of the nickel and cobalt as hydroxide phase. Hydroxides from several plants are transported to a central refinery where the hydroxide is redissolved in ammoniacal solutions and nickel and cobalt are separated and reduced to metal.
This project will examine t ....Enhanced metal recovery from a modified Caron leach of mixed nickel-cobalt intermediate concentrate. Nickel metal production from lateritic deposits involves dissolution in acid followed by purification and selective alkaline precipitation of the nickel and cobalt as hydroxide phase. Hydroxides from several plants are transported to a central refinery where the hydroxide is redissolved in ammoniacal solutions and nickel and cobalt are separated and reduced to metal.
This project will examine the effect of preparation conditions and aging of the hydroxide precipitate on the refining process.
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A Genome-wide Search For Genes Underlying The Developmental Origins Of Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,022,552.00
Summary
Epidemic rises in the incidence of many chronic diseases such as obesity, type 2 diabetes, hypertension, coronary artery disease and mental illness have occurred in Australia over the last two decades. Antenatal, early life and childhood factors have been consistently associated with the development of such diseases. We propose to conduct a genome-wide scan in an exceptional longitudinal birth cohort in order to identify the genetic mechanisms linking early life event and adult disease.