Striking The Balance: Combining Best Patient Outcomes And Cost-effective Interventions To Manage Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
This research will combine effective patient outcomes with strategic spending of health dollars. Through detailed analyses of current and recent clinical trials on cardiovascular disease, this project will identify treatments that provide the most benefit to patients’ quality of life and, crucially, will also be the most cost-effective to fund. This will pave the way for similar processes to be used in other areas of health to develop cost-effective healthcare programs for vulnerable groups.
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Ovarian and endometrial cancer affect >3,200 women each year in Australia and 3 or 4 women die from these cancers every day. The overall aim of my program of research is to reduce the burden of these cancers in future generations of Australian women by increasing our understanding of (i) what causes them, (ii) how we can optimise patient management to enhance patient outcomes and (ii) how lifestyle changes might improve quality and life and survival, for women who are diagnosed with them.
New Antibiotics And Treatment Methods Against Drug-resistant Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$766,468.00
Summary
Infectious disease is a leading cause of death, and the emergence of "superbugs" in the community and hospitals is of grave concern. We are developing new, powerful antibiotics that can kill superbugs using ‘forgotten’ drugs from the 1970s. These will combat bacteria that cause pneumonia, skin and urinary track infections; diseases that cause death and discomfort for thousands of Australians today. We will also develop methods to directly remove bacteria from blood infections.
Infertility remains a devastating disease for many couples, despite the success of IVF, as treatment is often unsuccessful, or remains out-of-reach for both health and/or financial reasons. My fellowship aims to improve our understanding of some of the causes of infertility in women. This will translate to a new infertility treatment that is safer for their health and provides for improved long-term health outcomes for their children.
Molecular Genetic Risk Factors And Mechanisms In Blinding Eye Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This project aims to understand the genetic causes of blinding eye diseases. We have recently identified genetic variation that contributes to the risk of glaucoma and diabetic eye disease. We are exploring the mechanisms through which this leads to disease by looking at differences in the genes in patients with disease compared to unaffected individuals. We hope to be able to identify genes that could be the target of new therapies to prevent blindness and visual impairment in the community.
Increasing Knowledge About Substance Use, Mental Health And Harms, And Interventions To Prevent And Reduce Harm
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
This Fellowship comprises three programmes of work: 1. epidemiology of illicit drug use (including the natural history of use: incidence, prevalence, persistence, desistance and relapse), contribution to the burden of disease; 2. Pharmaceutical opioids, the impact of opioid dependence, and treatments to reduce harm; 3. Risk and resilience in young people. This work will inform prevention, early intervention and treatment initiatives.
Targeting Mechanisms That Promote Cancer Cell Survival: Genetic And Chemical Approaches To Unravel The Molecular Mechanisms That Drive Tumour Formation, Develop Novel Molecular And Chemical Probes, And Discover New Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$751,854.00
Summary
One in three of us are likely to die from cancers. Groundbreaking research, including those made by Prof Huang, has revealed some of the reasons why cancers arise. An attractive way to transform the poor outcomes for cancer patients is to develop better medicines based on findings made by the basic researchers. Prof Huang leads a team at WEHI, including chemists, focused on developing better drugs that exploit knowledge garnered through such basic research in order to improve cancer treatment.
Interactions Between Vasoactive, Epigenetic And Immunogenic Pathways In The Development Of Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$664,584.00
Summary
In our community, diabetic retinopathy is the leading cause of vision loss in people of working age. As the prevalence of diabetic retinopathy increases, there is an urgent need to understand the factors that cause its development in order to develop new treatments. This proposal will explore the contribution of hormones, the memory of retinal cells to high glucose and stress, and the immune system to diabetic retinopathy. The goal is to develop new and improved treatments for Australians.
My research projects in the fields of cancer biology, vascular biology and immunology assess molecular mechanisms of vascular remodelling and implications for disease.