Child Disability:understanding Determinants And Improving Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$697,605.00
Summary
The overall goals of my research are: to learn more about the causes of developmental disorders so that we can either prevent them occurring, or develop effective treatments for them; to improve the understanding, diagnosis and management of rare genetic disorders by developing and maintaining registers and by collaborating internationally; and to investigate the impact of rare and common developmental disorders on the health and quality of life of the affected child and their family.
Increasing Value, Reducing Waste From Incomplete Or Unusable Reports Of Medical Research
Funder
National Health and Medical Research Council
Funding Amount
$788,486.00
Summary
We estimated that the avoidable waste in research - from design flaws, non-publication, and inadequate reporting - results in over $85 Billion annual loss. I will research innovations to reduce this waste. My focus is particularly on non-drug interventions - exercises, dietary changes, self-monitoring, e-health applications – which are often effective but more difficult to use in clinical practice, and being compiled in my recently founded Handbook of Non-Drug Interventions (see RACGP website).
New Interventions To End Neglected Tropical Diseases In Asia
Funder
National Health and Medical Research Council
Funding Amount
$926,980.00
Summary
My research goal is to eliminate parasitic worm infestations globally. These parasites cause substantial illness and affect the world's poorest people. Programs that drug treat infected individuals operate but these are neither effective nor sustainable. Our research has shown that additional measures, such as vaccination and health education, are needed and we aim to develop and field test a combination of interventions that will lead to their sustainable control and eventual elimination.
Delivering Quality Maternal And Newborn Care: Translating ‘evidence-based Practice’ Into ‘every-day Practice’
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
More than 300,000 women each year in Australia use maternity services. Unfortunately these are not always based on the best available evidence and there are considerable variations across the country. This research will provide much needed information to ensure that all women receive evidence-based care not just some women. The research will be initially conducted in south western Sydney but will ultimately improve the quality of care offered to women and babies across the country and beyond.
Innovative School-based Interventions To Improve Mental Health And The Social And Emotional Development Of Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
I am a Professor in the Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia and the Telethon Kids Institute. My research develops and delivers interventions that improve the quality of life, health, education, safety and social justice outcomes for Australian children. My work is particularly focused on ways to reduce harms from bullying and cyberbullying among children and adolescents.
A common characteristic of cancer is the failure of cells to die when they normally would. One of the problems with many cancer therapies is that they rely on the integrity of signalling pathways to the normal ‘death machinery’ of the cell to do their job. By understanding how the molecular death machine operates we are fashioning new drugs that can target it directly, thus bypassing the very pathways that are so frequently disrupted in tumour cells.
Innovations In Prevention And Treatment Of Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
Novel clinical trials and related basic science research in the prevention and treatment of heart and blood vessel disease and diabetic complications will be undertaken, building on extensive collaborations and novel discoveries to date.
G protein-coupled receptors are proteins that exist on every human cell, where they sense, and respond to environmental stimuli. Because of their importance they are targeted by drugs to treat many diseases. However little is known about how drugs activate these receptors and this has hindered new drug development. I use state-of-the-art technology to determine how drugs activate receptors and develop new methods for drug discovery. This work will have major impact on the Pharmaceutical industry
Dr. Ivo Mueller is global leader in the study of non-African malaria with a special focus on the SW Pacific and on P. vivax. His research at the Walter & Eliza Hall Institute focuses on population-based studies of host-vector-parasite interactions and their effect on burden and transmission of different malaria parasites as well as improving treatment & prevention of malaria in children and pregnant mothers and thereby contributing to the development of new tools to control and eliminate malaria
Structure-based And Fragment-based Approaches To Developing New Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
Two powerful and complementary approaches to developing new drugs will be combined to target proteins that play key roles in malaria and other parasite and bacterial infections with the aim of developing new therapeutics. In addition, the potential of peptide toxins to treat autoimmune diseases such as multiple sclerosis, as well as chronic pain and other conditions, will be exploited to develop new drugs.