Efficient Design for Generalized Linear Models. In industrial, commercial and social research, we collect data in order to predict the outcome of a process based on the inputs to that process. We want to maximize the information that is gained from the data. Good planning is crucially important to achieve this. This project will determine how best to select the inputs to the process for many situations that occur in research. A computer package to answer these questions will be written. The nati ....Efficient Design for Generalized Linear Models. In industrial, commercial and social research, we collect data in order to predict the outcome of a process based on the inputs to that process. We want to maximize the information that is gained from the data. Good planning is crucially important to achieve this. This project will determine how best to select the inputs to the process for many situations that occur in research. A computer package to answer these questions will be written. The nation will benefit from a fundamental increase in efficiency of research and, therefore, in efficient use of research dollars.Read moreRead less
Innovations in Bayesian likelihood-free inference. Bayesian inference is a statistical method of choice in applied science. This project will develop innovative tools which permit Bayesian inference in problems considered intractable only a few years ago. These methods will expedite advances in multidisciplinary research across a range of applications. With these foundations, this project will accelerate national research efforts into improving frameworks for projecting trends in water availabil ....Innovations in Bayesian likelihood-free inference. Bayesian inference is a statistical method of choice in applied science. This project will develop innovative tools which permit Bayesian inference in problems considered intractable only a few years ago. These methods will expedite advances in multidisciplinary research across a range of applications. With these foundations, this project will accelerate national research efforts into improving frameworks for projecting trends in water availability and management, the impact of climate extremes, telecommunications engineering, HIV and infectious disease modelling and biostatistics. With many sectors unable to recruit appropriately trained statisticians within Australia, this project will train four PhD students in Bayesian statistics.
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Statistical methods for analysing multi-source microarray data and building gene regulatory networks. I will devise a statistical learning technique that does not force a gene to be assigned to exactly one category. This technique reflects the biological reality that a gene can belong to two or more functional categories. Therefore, the new technique will improve a model's ability to identify regulatory genes in different types of cancer; these regulatory genes can be targeted by new anti-cancer ....Statistical methods for analysing multi-source microarray data and building gene regulatory networks. I will devise a statistical learning technique that does not force a gene to be assigned to exactly one category. This technique reflects the biological reality that a gene can belong to two or more functional categories. Therefore, the new technique will improve a model's ability to identify regulatory genes in different types of cancer; these regulatory genes can be targeted by new anti-cancer drugs resulting in a more effective treatment. I will model gene regulatory networks using microarray data from multiple sources. These networks will be used to identify regulatory cliques - a group of genes that are vital for a cellular function. This will improve our understanding of debilitating conditions such as asthma.Read moreRead less
Statistical methods and tools for integrative microarray analysis. Tools used for biological and medical research have been evolving and there has been an increase in high-throughput technologies such as genome sequencing and DNA microarray. The growing number of entries and the increasing availability of public microarray repositories and other sequence databases have generated the new challenge of developing tools to efficiently integrate data by different research groups. This research provi ....Statistical methods and tools for integrative microarray analysis. Tools used for biological and medical research have been evolving and there has been an increase in high-throughput technologies such as genome sequencing and DNA microarray. The growing number of entries and the increasing availability of public microarray repositories and other sequence databases have generated the new challenge of developing tools to efficiently integrate data by different research groups. This research provides new statistical methods to integrate different data sets. Its application in the biomedical field will allow researchers to effectively interpret the myriad of data generated within the community.Read moreRead less
Statistical and computational methods using a multiscale approach for protein identification and quantification. Proteins are critically important in the onset and ongoing illness associated with disease. Key proteins may serve as markers to diagnose or predict the course of a disease, or even become the target of pharmaceuticals. Accurate, efficient and robust algorithms are a critical component in protein identification. This research provides novel statistical algorithms for protein identific ....Statistical and computational methods using a multiscale approach for protein identification and quantification. Proteins are critically important in the onset and ongoing illness associated with disease. Key proteins may serve as markers to diagnose or predict the course of a disease, or even become the target of pharmaceuticals. Accurate, efficient and robust algorithms are a critical component in protein identification. This research provides novel statistical algorithms for protein identification using multiscale analysis techniques. Their applications in the bio-medical field will enable Australian and international researchers to identify key proteins more accurately, than current methods, leading to improve health, medical, and biological research outcomes.Read moreRead less
New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks. Understanding gene regulatory networks is critical in the understanding of fundamental biological systems. These networks have important implications for the discovery of fundamental mechanisms relating to the diagnosis and management of many illnesses. This research will provide new statistical methods to identify regulatory micro-ribonucleic acid modules and to understand their relationship in gene regu ....New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks. Understanding gene regulatory networks is critical in the understanding of fundamental biological systems. These networks have important implications for the discovery of fundamental mechanisms relating to the diagnosis and management of many illnesses. This research will provide new statistical methods to identify regulatory micro-ribonucleic acid modules and to understand their relationship in gene regulatory networks through multiple covariance estimation and multivariate classification techniques. My results should enable researchers to better understand the regulation underlying biological systems, leading to improved human health, medical and biological research outcomes.Read moreRead less
Bayesian Inference for Multivariate Hierarchical Regression Models. This project will develop Bayesian methodology for analysing multivariate regression models. The distribution of each measurement can be discrete or continuous, with the dependence between measurements obtained through the correlation matrix of a Gaussian copula. Model parsimony is obtained by identifying zero elements in the correlation matrix or its inverse and by variable selection on the regression parameters. The results wi ....Bayesian Inference for Multivariate Hierarchical Regression Models. This project will develop Bayesian methodology for analysing multivariate regression models. The distribution of each measurement can be discrete or continuous, with the dependence between measurements obtained through the correlation matrix of a Gaussian copula. Model parsimony is obtained by identifying zero elements in the correlation matrix or its inverse and by variable selection on the regression parameters. The results will be applied to solve problems in finance, health management and marketing. In all these fields multiple observations are often taken per individual or time period and the models need to incorporate measures of dependence and uncertainty.Read moreRead less
Trans-dimensional and Approximate Bayesian Computation. Many applied scientists in Australia, particularly those in the biological, medical and environmental sciences are now interested in incorporating Bayesian statistical methodologies into their research.
The development of more generic and efficient Bayesian statistical methods will not only benefit applied statisticians but also the more occasional users of statistics in other disciplinary areas. The success of this project will enhance Au ....Trans-dimensional and Approximate Bayesian Computation. Many applied scientists in Australia, particularly those in the biological, medical and environmental sciences are now interested in incorporating Bayesian statistical methodologies into their research.
The development of more generic and efficient Bayesian statistical methods will not only benefit applied statisticians but also the more occasional users of statistics in other disciplinary areas. The success of this project will enhance Australia's reputation as a strong contributor to the development of Bayesian methodologies. Two PhD students will also be provided training in computational Bayesian statistics.Read moreRead less
Asymptotic Expansions and Large Deviations in Probability and Statistics: Theory and Applications. Statistics is the major enabling science in a number of disciplines. This is fundamental research in probability and statistics but it has wide applications in Biology and Social Sciences which will ultimately be of national benefit. The behaviour of self normalized sums is an exciting new area of fundamental research that has implications for the application of statistics in many areas. U-statist ....Asymptotic Expansions and Large Deviations in Probability and Statistics: Theory and Applications. Statistics is the major enabling science in a number of disciplines. This is fundamental research in probability and statistics but it has wide applications in Biology and Social Sciences which will ultimately be of national benefit. The behaviour of self normalized sums is an exciting new area of fundamental research that has implications for the application of statistics in many areas. U-statistics for dependent situations has direct application to understanding financial time series and the analysis of sample survey data. Saddlepoint methods provide extremely accurate approximations in a number of important applications.
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Empirical saddlepoint approximations and self-normalized limit theorems. Finite population sampling and resampling methods such as the bootstrap and randomization methods are central in a number of areas of application and M-estimates are the major method used to give robust methods under mild conditions; in both these areas statistics are used which are Studentized or self-normalized. We will develop asymptotic approaches for such statistics. Saddlepoint and empirical saddlepoint methods will ....Empirical saddlepoint approximations and self-normalized limit theorems. Finite population sampling and resampling methods such as the bootstrap and randomization methods are central in a number of areas of application and M-estimates are the major method used to give robust methods under mild conditions; in both these areas statistics are used which are Studentized or self-normalized. We will develop asymptotic approaches for such statistics. Saddlepoint and empirical saddlepoint methods will be used to give methods which have second order relative accuracy in large deviation regions and we will obtain limit results and Edgeworth approximations. Emphasis will be on obtaining results under weak conditions necessary for applications.Read moreRead less