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Low Cost High Precision Radiotherapy: A Synergistic Framework For Tumour Tracking During Treatment
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Advances in technology have enabled radiotherapy to become more sophisticated and more efficient at treating cancer. Yet, despite its sophistication, today radiotherapy suffers from a major problem: whilst we routinely image patients prior to treatment, no anatomical information is available during treatment. This project aims to solve this problem by making use of a number of sensors that are already available in a radiotherapy to track the tumours positions during treatment, when it counts.
Real-time In-vivo Imaging During Lung Cancer Radiotherapy
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung tumours move in clinically significant and unpredicable ways. Current radiotherapy is limited by the lack of real-time imaging to monitor tumour motion. The aim of this project is to develop and clinically implement Real-time In-vivo Imaging to enable motion-adaptive radiotherapy and thereby improve treatment outcomes. Real-time In-vivo Imaging is a software technology that will be applicalbe to 90% of modern radiotherapy systems globally and will enable wide access to advanced cancer care.
Interdisciplinary Insights Into The Rational Design Of Malaria Therapy And Vaccines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Malaria is a global health concern with almost half a million deaths annually. There is an urgent need for a highly effective malaria vaccine and new antimalarials. However, despite decades of research into this pathogen, our understanding of what causes illness in a person and how immunity operates is limited. This project will use a mathematical modelling approach to provide a new way to understand infection, as a rapidly changing and intricate process.
Unravelling How Protein Signalling Networks Integrate To Control T Cell Fate
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Rational design of drug combinations to manipulate the immune response requires an understanding of how different signals work together to control cell behaviour. The PIM kinase proteins are known to regulate important properties of immune cells, including division and death and when dysregulated can lead to cancer. I will perform a comprehensive, unbiased investigation of how the PIM kinases interact with other protein signalling pathways to control the immune response in health and disease.
Fundamental Advancement Of Knowledge Of Plasmodium Vivax Biology, Drug Susceptibility And Transmission
Funder
National Health and Medical Research Council
Funding Amount
$316,067.00
Summary
Plasmodium vivax is the most widespread malaria parasite causing over 80 million cases per year. Yet, current means to counter this parasite are grossly inadequate. Vast knowledge gaps exist due to unavailability of continuous cultures, high throughput drug assays and the poor understanding of transmission. This inhibits the development of new treatments for P. vivax. This project will fundamentally advance knowledge of the biology and epidemiology of this important, but neglected pathogen.
Population-based Data Linkage And Modelling Studies To Evaluate And Inform Australia’s Immunisation Program
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Despite the overall success of immunisation programs, outbreaks of preventable diseases continue and Indigenous children still suffer a higher burden of illness. We will study a cohort of infants in New South Wales and data about their illnesses and vaccinations to provide accurate measures program performance. The findings will aid development of strategies to target high risk children, and more realistic models about future outcomes, so that the benefits of immunisation are optimised.