Quantum correlations in ultra-cold Fermi gases. The field of ultra-cold Fermi gases provides a unique opportunity to develop and test theoretical methods for novel experimental environments of exceptional purity and simplicity. This improved understanding will have potential applications in many fields, ranging from the astrophysics of neutron stars to condensed matter systems such as superconductors or nanostructures. Just as importantly, the project will develop linkages with world leading the ....Quantum correlations in ultra-cold Fermi gases. The field of ultra-cold Fermi gases provides a unique opportunity to develop and test theoretical methods for novel experimental environments of exceptional purity and simplicity. This improved understanding will have potential applications in many fields, ranging from the astrophysics of neutron stars to condensed matter systems such as superconductors or nanostructures. Just as importantly, the project will develop linkages with world leading theoretical groups, which will greatly aid research student education. There are direct applications to experiments on molecule formation with ultra-cold fermions in the ARC Centre of Excellence for Quantum-Atom Optics.Read moreRead less
Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress ....Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress in a feasible time frame. In three dimensions this project will strengthen the distinguished computational topology community in Melbourne, led by pioneers such as Rubinstein, Goodman, Hodgson as well as the applicant himself.Read moreRead less
ARC Centre for Complex Dynamic Systems & Control. Complex dynamic systems are an inescapable feature of the world we live in. Modelling, analysing and optimizing complex behaviour is crucial for environment, process industry, biomedical, energy distribution, transportation and other applications. The Centre for Complex Dynamic Systems and Control will become an international authority in the analysis, design and optimization of complex dynamic systems, pursuing both outstanding fundamental and c ....ARC Centre for Complex Dynamic Systems & Control. Complex dynamic systems are an inescapable feature of the world we live in. Modelling, analysing and optimizing complex behaviour is crucial for environment, process industry, biomedical, energy distribution, transportation and other applications. The Centre for Complex Dynamic Systems and Control will become an international authority in the analysis, design and optimization of complex dynamic systems, pursuing both outstanding fundamental and cutting edge applied research outcomes. These outcomes will be of specific benefit to partner organizations including minerals, process, metal forming, and automotive industries.Read moreRead less
High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction wi ....High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction with molecular modelling will enable the mapping (distance and orientation) of redox centres in complex multicentered metalloproteins (DMSDH and DorC) and in protein-protein complexes (DMSOR-DorC) providing information on the pathway of electron transfer and hence the role of the pyranopterins.Read moreRead less
Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
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Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Coarse Grained Parallel Algorithms. Various fields of research face barriers created by problems that are computationally hard and/or require processing of large amounts of data. For example, some computational biochemistry methods on protein or gene sequences can not be scaled up to data sets required for human health research because of performance problems. Parallel computing enables new research by increasing the size of solvable problems. In addition to fundamental parallel computing resear ....Coarse Grained Parallel Algorithms. Various fields of research face barriers created by problems that are computationally hard and/or require processing of large amounts of data. For example, some computational biochemistry methods on protein or gene sequences can not be scaled up to data sets required for human health research because of performance problems. Parallel computing enables new research by increasing the size of solvable problems. In addition to fundamental parallel computing research, this project studies parallel algorithms for structure-based drug design and protein-protein interaction prediction that will enable new biochemistry research, as well as parallel algorithms for data cubes that will help enable the next generation of very large data warehouses.Read moreRead less
Unsupervised learning of finite mixture models in data mining applications. The extraction of useful information from massively large databases is known as data mining. Its broad but vague goal is to find "interesting structure" in the data, which typically leads to breaking the data into clusters. To this end, we consider the fast, efficient, and automatic learning of finite mixture models in hugh data sets without any prior knowledge of the structure. This probabilistic approach to the discove ....Unsupervised learning of finite mixture models in data mining applications. The extraction of useful information from massively large databases is known as data mining. Its broad but vague goal is to find "interesting structure" in the data, which typically leads to breaking the data into clusters. To this end, we consider the fast, efficient, and automatic learning of finite mixture models in hugh data sets without any prior knowledge of the structure. This probabilistic approach to the discovery and validation of group structure in data mining applications will considerably enhance knowledge management and decision support in science, industry, and government.
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