The Interplay Between Viperin, Peroxisomes And The Cellular Innate Antiviral Response
Funder
National Health and Medical Research Council
Funding Amount
$556,127.00
Summary
Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.
Frontotemporal Dementia And Motor Neurodegenerative Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$11,583,107.00
Summary
Frontotemporal degeneration of the brain is a leading cause of morbidity. It is a pathologically heterogeneous group of rapidly-progressive disorders with behavioural, language and motor deficits. This research program brings together international leaders in clinical, pathological and biological research of these syndromes, aiming to fast track new knowledge and innovations to develop the necessary tools and therapies to effectively diagnose, manage and treat these disorders.
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-sp ....Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-specific results required. Community healthcare will benefit, through better diagnostic capabilities and customized treatment. Australia is well placed to profit further from this research, in view of the growing worldwide demand for more sophisticated, knowledge-based techniques in medicine.Read moreRead less
The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially imp ....The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially important in vascular disease where blood flow and blood vessels are affected by wall irregularities and lesions. The new knowledge generated by this project will have practical importance and, by identifying achievable outcomes, potentially major cost savings, in medical ultrasound.Read moreRead less
Signalling Pathways And Fungal Virulence – The Inositol Polyphosphate Kinase Pathway In Cryptococcus Neoformans
Funder
National Health and Medical Research Council
Funding Amount
$545,189.00
Summary
Bloodstream fungal infections kill millions of people per year world-wide and are costly to treat. A potentially fruitful strategy for developing new, urgently-needed drugs to fight these infections, is to target signalling pathways, which in fungi, are essential for establishing infection. This proposal investigates how one such pathway, the inositolpolyphosphate kinase pathway, allows fungi to establish infection and will determine which components are suitable targets for drug development.
'Fixed points': extending and deepening our understanding of mathematical and computational aspects of game theory. This work will extend and deepen our understanding of mathematical and computational aspects of game theory. It will produce computer code embodying new methods of solving systems of nonlinear equations, which is useful in many areas of applied research in economics, in other disciplines such as chemistry, and potentially in the analysis of business operations. The project will a ....'Fixed points': extending and deepening our understanding of mathematical and computational aspects of game theory. This work will extend and deepen our understanding of mathematical and computational aspects of game theory. It will produce computer code embodying new methods of solving systems of nonlinear equations, which is useful in many areas of applied research in economics, in other disciplines such as chemistry, and potentially in the analysis of business operations. The project will also deepen our understanding of the underlying mathematics of such systems, and of other mathematical foundations of economic research. One application will be a new measure of the relative power resulting from voting rules. Such measures assist the design of democratic institutions by allowing the designer to assess the fairness of the outcomes they produce.Read moreRead less
Explicit Construction of Global Function Fields with Many Rational Places. The use of error-correcting codes and cryptosystems is fundamental to the secure and reliable operation of many technological devices that we depend upon in our everyday lives. Essentially invisible, both coding theory and cryptography are essential for banking (ATM machines, e-banking), commerce (e-commerce), defense (cryptography) and entertainment (digital TV and radio, music CDs, DVDs). While certain families of "goo ....Explicit Construction of Global Function Fields with Many Rational Places. The use of error-correcting codes and cryptosystems is fundamental to the secure and reliable operation of many technological devices that we depend upon in our everyday lives. Essentially invisible, both coding theory and cryptography are essential for banking (ATM machines, e-banking), commerce (e-commerce), defense (cryptography) and entertainment (digital TV and radio, music CDs, DVDs). While certain families of "good" codes and cryptosystems can be constructed from specific function fields whose existence is guaranteed by abstract theory, often no actual construction for the function field is currently known. We aim to close this gap, making a greater range of "good" codes and cryptosystems available for practical applications.
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Constructive Representation Theory and its Applications. The algorithms developed will make it possible to determine the different ways (representations) in which a group of symmetries may be realised as transformations of some space. Such knowledge is required in many areas including differential equations, digital signal processing, engineering ('strut-and-cable' constructions), the design of telephone networks, crystallography and quantum information processing. The high-performance tools fo ....Constructive Representation Theory and its Applications. The algorithms developed will make it possible to determine the different ways (representations) in which a group of symmetries may be realised as transformations of some space. Such knowledge is required in many areas including differential equations, digital signal processing, engineering ('strut-and-cable' constructions), the design of telephone networks, crystallography and quantum information processing. The high-performance tools for linear algebra developed will also find application in cryptography and coding theory. This work represents the latest stage in a long-term project to discover practical algorithms for elucidating the properties of complex algebraic structures - an area where Australia is a world-leader.Read moreRead less
Computational Methods for Matrix Groups and Group Representations. The symmetry of a system is captured mathematically by the notion of a group. A set of matrices closed under multiplication and the taking of inverses is an important example of a group. For instance, the symmetries of many physical systems and other objects are captured by a group of matrices over the complex numbers. This project will develop the computational tools necessary for constructing and analyzing finite matrix groups ....Computational Methods for Matrix Groups and Group Representations. The symmetry of a system is captured mathematically by the notion of a group. A set of matrices closed under multiplication and the taking of inverses is an important example of a group. For instance, the symmetries of many physical systems and other objects are captured by a group of matrices over the complex numbers. This project will develop the computational tools necessary for constructing and analyzing finite matrix groups over infinite fields such as the complex numbers. These methods will find immediate application to many areas of science and engineering and, in particular, to the theory of quantum computation.
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