Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
Read moreRead less
Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress ....Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress in a feasible time frame. In three dimensions this project will strengthen the distinguished computational topology community in Melbourne, led by pioneers such as Rubinstein, Goodman, Hodgson as well as the applicant himself.Read moreRead less
Quantum correlations in ultra-cold Fermi gases. The field of ultra-cold Fermi gases provides a unique opportunity to develop and test theoretical methods for novel experimental environments of exceptional purity and simplicity. This improved understanding will have potential applications in many fields, ranging from the astrophysics of neutron stars to condensed matter systems such as superconductors or nanostructures. Just as importantly, the project will develop linkages with world leading the ....Quantum correlations in ultra-cold Fermi gases. The field of ultra-cold Fermi gases provides a unique opportunity to develop and test theoretical methods for novel experimental environments of exceptional purity and simplicity. This improved understanding will have potential applications in many fields, ranging from the astrophysics of neutron stars to condensed matter systems such as superconductors or nanostructures. Just as importantly, the project will develop linkages with world leading theoretical groups, which will greatly aid research student education. There are direct applications to experiments on molecule formation with ultra-cold fermions in the ARC Centre of Excellence for Quantum-Atom Optics.Read moreRead less
Design and Development of a Web-based Intelligent Multimedia Mining System. Increasing amounts of digital multimedia data in the form of video is being captured and stored. However, even the most advanced storage and retrieval techniques lack the features required to be used singly, or in combination, to fulfil a wide range of user needs and rapid access to multimedia resources, even in a very large video database. The core challenges are indeed to develop efficient, smart and intelligent web-ba ....Design and Development of a Web-based Intelligent Multimedia Mining System. Increasing amounts of digital multimedia data in the form of video is being captured and stored. However, even the most advanced storage and retrieval techniques lack the features required to be used singly, or in combination, to fulfil a wide range of user needs and rapid access to multimedia resources, even in a very large video database. The core challenges are indeed to develop efficient, smart and intelligent web-based multimedia mining in Australia and elsewhere. In this project, we will explore techniques and develop algorithms for content-based multimedia retrieval and mining in multimedia databases.Read moreRead less
An Extensible agent-based framework for exploring climate change adaptation. The benefit of this project is the provision of an extensible leading edge technological platform for exploration of critical problems of Climate Change Adaptation (CCA). This will enable policy makers and social scientists to explore the complex interactions of different approaches to adaptation thus informing this critical area understanding. The research questions addressed will also provide more general benefits in ....An Extensible agent-based framework for exploring climate change adaptation. The benefit of this project is the provision of an extensible leading edge technological platform for exploration of critical problems of Climate Change Adaptation (CCA). This will enable policy makers and social scientists to explore the complex interactions of different approaches to adaptation thus informing this critical area understanding. The research questions addressed will also provide more general benefits in the area of agent based modelling and simulation, facilitating principled modelling of more complex entities within simulations. Building on top of a platform with an existing large user base facilitates contributions to the extensible platform, and the application area of CCA, by a wide range of people.Read moreRead less
Thermo-mechanical interactive atlas of basin evolution. We propose to create a thermo-mechanical interactive atlas of basin evolution as a desktop geodynamic modelling resource for exploration geologists. The atlas will allow the user to iteratively run our 2D/3D basin modelling software ELLIPSIS to alter model parameters until they match observed basin geometries or thermal history. Model iteration will be based on interactive user evaluation of model outputs and genetic algorithms, which pr ....Thermo-mechanical interactive atlas of basin evolution. We propose to create a thermo-mechanical interactive atlas of basin evolution as a desktop geodynamic modelling resource for exploration geologists. The atlas will allow the user to iteratively run our 2D/3D basin modelling software ELLIPSIS to alter model parameters until they match observed basin geometries or thermal history. Model iteration will be based on interactive user evaluation of model outputs and genetic algorithms, which progressively modify the solution set by mimicking the evolutionary behavior of biological systems (selection, cross-over and mutation), until an acceptable result is achieved. The interactive atlas will be applied to Australian and international case studies.Read moreRead less
Wavelet approaches for solving nonlinear dynamic systems in process engineering. The success of the proposed project will enable us to obtain more accurate numerical solutions for the nonlinear dynamical systems arising from process engineering. This ensures the potential for understanding and optimising industrial and engineering processes. Hence, a wide range of processing industries in Australia, such as agricultural chemicals, mineral processing, food, detergents, pharmaceuticals, ceramics ....Wavelet approaches for solving nonlinear dynamic systems in process engineering. The success of the proposed project will enable us to obtain more accurate numerical solutions for the nonlinear dynamical systems arising from process engineering. This ensures the potential for understanding and optimising industrial and engineering processes. Hence, a wide range of processing industries in Australia, such as agricultural chemicals, mineral processing, food, detergents, pharmaceuticals, ceramics and specialty chemicals will benefit from the results of this project. This will ensure globally competitive production and, therefore, greater contributions to the Australian economy.Read moreRead less
Special Research Initiatives - Grant ID: SR0566892
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
The EarthByte software and database system. Earth processes over geological timescales cannot be understood outside of a plate tectonic context. However, no standard tool exists to explore the causes and effects of lithosphere-mantle interaction in accordance with past plate configurations. Our aim is to develop a Palaeo-Geographic Information System called EarthByte that will connect the open source and architecture-independent GPlates and GMT software, and implement XML-based service interfac ....The EarthByte software and database system. Earth processes over geological timescales cannot be understood outside of a plate tectonic context. However, no standard tool exists to explore the causes and effects of lithosphere-mantle interaction in accordance with past plate configurations. Our aim is to develop a Palaeo-Geographic Information System called EarthByte that will connect the open source and architecture-independent GPlates and GMT software, and implement XML-based service interfaces and databases. EarthByte will create the foundation for an e-geoscience framework for grid-based data access and Earth process modelling by linking geological and geophysical observations to palaeogeographic models for constraining mantle convection and lithospheric deformation.Read moreRead less
Development of an Integrated Platform for Performance-Based Safety Assessment. Building fires are the cause of major fatalities and injuries amongst all types of accidental fires in Australia. With significant advancement in numerical simulation technique, computer models are becoming acceptable tools for fire safety designs. Nonetheless, these methods still suffer from large amount of manual inputs and lengthy computational times. This research project will address the prevalent deficiency in m ....Development of an Integrated Platform for Performance-Based Safety Assessment. Building fires are the cause of major fatalities and injuries amongst all types of accidental fires in Australia. With significant advancement in numerical simulation technique, computer models are becoming acceptable tools for fire safety designs. Nonetheless, these methods still suffer from large amount of manual inputs and lengthy computational times. This research project will address the prevalent deficiency in many of these computer models and develop a novel and innovative design methodology. The success of this project will revolutionize the computational tools for the industry realizing a convenient, robust and time-saving integrated platform catering for increasing future market demand.Read moreRead less
Charting connectivity in the healthy and diseased brain. Australia's endemic mental health burden is predicted to escalate as its population ages. This project will: (1) endow medicine with a diagnostic capability enabling earlier and more-accurate diagnosis of brain disorders and mental illnesses; and, (2) pinpoint brain circuit disruptions telltale of particular diseases. This is a world-first and promises a scientific basis for new-generation therapies and treatments. This project will enable ....Charting connectivity in the healthy and diseased brain. Australia's endemic mental health burden is predicted to escalate as its population ages. This project will: (1) endow medicine with a diagnostic capability enabling earlier and more-accurate diagnosis of brain disorders and mental illnesses; and, (2) pinpoint brain circuit disruptions telltale of particular diseases. This is a world-first and promises a scientific basis for new-generation therapies and treatments. This project will enable the APD to disseminate the specialist knowledge acquired as an ARC Fellow at Harvard in 2008 to Australian researchers, thereby advancing Australia's international standing in science.Read moreRead less