Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries ....Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries designed to correct movement abnormalities in these patients. Realistic computer simulations of human movement can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This resear ....Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This research program will develop the complex signal processing and system methodology needed to create a suitable tool set.Read moreRead less
Modelling patient flows through hospitals: optimizing effective use of resources. Hospitals are complex, dynamic systems confronted by increased demand in the face of shrinking real capacity. Managing such systems is currently undertaken with sub-optimal analytical support, particularly when demand and capacity are changing and resources must be manipulated to respond to such changes. In this project, the investigators will apply a mathematical modelling approach to the analysis of hospital pati ....Modelling patient flows through hospitals: optimizing effective use of resources. Hospitals are complex, dynamic systems confronted by increased demand in the face of shrinking real capacity. Managing such systems is currently undertaken with sub-optimal analytical support, particularly when demand and capacity are changing and resources must be manipulated to respond to such changes. In this project, the investigators will apply a mathematical modelling approach to the analysis of hospital patient flows. Furthermore, they will employ statistical process control methodologies to the problem of recognising and responding to changes in the flows, so that performance objectives are met. In doing this, they will give health service managers and clinicians a significant advantage in deciding how best to manage a constrained resource to maximize access, throughput and patient outcomes.Read moreRead less
Non-invasive assessment of hip fracture risk in elderly people. No falls, no fractures - this will be the main benefit of the proposed research. The most significant outcome will be new computational tools to improve current understanding of the biomechanics of falls and bone fragility in elderly people, which, in turn, will help to reduce healthcare costs associated with the treatment and management of hip fractures. Realistic models and computer simulations of human movement can play a pivota ....Non-invasive assessment of hip fracture risk in elderly people. No falls, no fractures - this will be the main benefit of the proposed research. The most significant outcome will be new computational tools to improve current understanding of the biomechanics of falls and bone fragility in elderly people, which, in turn, will help to reduce healthcare costs associated with the treatment and management of hip fractures. Realistic models and computer simulations of human movement can play a pivotal role in three of Australia's largest industries: healthcare, through the diagnosis and treatment of movement disorders; sports, through the development of personalized training programs for elite athletes; and entertainment, through the development of video/digital games and animated films.Read moreRead less
A Control Systems Approach for Understanding Human Locomotion. This proposal addresses fundamental, difficult questions in the context of human movement: How do muscles move our limbs during walking? How do the nervous system and muscles work together to control movement? Realistic computer simulations of human movement can help answer these questions and, in so doing, can play a pivotal role in three of Australia's largest industries: healthcare, through clinical gait analysis and gait rehabili ....A Control Systems Approach for Understanding Human Locomotion. This proposal addresses fundamental, difficult questions in the context of human movement: How do muscles move our limbs during walking? How do the nervous system and muscles work together to control movement? Realistic computer simulations of human movement can help answer these questions and, in so doing, can play a pivotal role in three of Australia's largest industries: healthcare, through clinical gait analysis and gait rehabilitation (diagnosis and treatment of movement disorders); sports, through the development of personalized training programs for elite athletes; and entertainment, through the development of video/digital games and animated films (creation of virtual life-like actors).Read moreRead less
Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo. Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity o ....Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo. Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity of current knee implant designs. Realistic computer simulations of human movement also can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanis ....Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanisms underlying arrhythmias which contribute to ?sudden cardiac death? in young men, and suggesting strategies for artificial pacemakers to effectively arrest abnormal rhythms before they convert to potentially fatal fibrillation.Read moreRead less
Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optim ....Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optimisation of Complex Systems.Read moreRead less
Constructive control of interconnected systems. Sustainability and competitiveness of the Australian industry critically depends on the progress in the technological area of distributed information processing and control. This project will contribute to the existing Australian research effort in this area by advancing the control systems theory which underpins many cutting edge technologies in areas of immediate national interest.
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.