Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultim ....Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultimately inform our capacity to better deploy personalised medicines.Read moreRead less
A Novel Geometric Approach to Shocks in Reaction-Nonlinear Diffusion Models. Reaction-nonlinear diffusion models play a vital role in the study of cell migration and population dynamics. However, the presence of aggregation, or backward diffusion, leads to the formation of shock waves - distinct, sharp interfaces between different populations of densities of cells - and the breakdown of the model. This project will develop new geometric methods to explain the formation and temporal evolution of ....A Novel Geometric Approach to Shocks in Reaction-Nonlinear Diffusion Models. Reaction-nonlinear diffusion models play a vital role in the study of cell migration and population dynamics. However, the presence of aggregation, or backward diffusion, leads to the formation of shock waves - distinct, sharp interfaces between different populations of densities of cells - and the breakdown of the model. This project will develop new geometric methods to explain the formation and temporal evolution of these shock waves, while simultaneously unifying existing regularisation techniques under a single, geometric banner. It will devise innovative tools in singular perturbation theory and stability analysis that will identify key parameters in the creation of shock waves, as well as their dynamic behaviour.Read moreRead less
Sewer Monitoring and Management in the Digital Era. Overflow, flooding, corrosion, and odorous emissions are persistent issues for utilities managing sewers. Current sewer maintenance is reactive, and focuses on solving problems in local networks, despite that optimal solutions require a system-wide approach. Capitalising on recent development in IoT sensors, wireless transmission, and machine learning, this multidisciplinary project aims to develop digital-twin supported data analytics for proa ....Sewer Monitoring and Management in the Digital Era. Overflow, flooding, corrosion, and odorous emissions are persistent issues for utilities managing sewers. Current sewer maintenance is reactive, and focuses on solving problems in local networks, despite that optimal solutions require a system-wide approach. Capitalising on recent development in IoT sensors, wireless transmission, and machine learning, this multidisciplinary project aims to develop digital-twin supported data analytics for proactive sewer management including network-wide real-time control. The project aims to generate significant social, environmental and economic benefits by enabling utilities to better protect public and environmental health, reduce sewer odour and greenhouse gas emissions, and extend sewer asset life.Read moreRead less
New biocatalysts for selective chemical oxidations under extreme conditions. This project will identify and design new enzyme biocatalysts which function under extreme conditions such as elevated temperature and high concentrations of peroxides. These enzymes will be sourced from microorganisms which are located in extreme biological environments e.g. hot springs (the so-called extremophiles). The expected outcome of this project are the identification of robust enzymes which can catalyse select ....New biocatalysts for selective chemical oxidations under extreme conditions. This project will identify and design new enzyme biocatalysts which function under extreme conditions such as elevated temperature and high concentrations of peroxides. These enzymes will be sourced from microorganisms which are located in extreme biological environments e.g. hot springs (the so-called extremophiles). The expected outcome of this project are the identification of robust enzymes which can catalyse selective oxidation reactions in complex organic molecules, such as steroids. The new biocatalysts developed in this project will have significant benefit in the development of new routes to access bespoke molecules of value in fine chemical synthesis and drug development.
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Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect ....Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect productivity, enhance predictive capability, and initiate advanced breeding strategies to develop new crop varieties with superior resilience against changing climates. This should provide significant benefits, such as profit stability for wheat growers, elevated global market position and improved food security.Read moreRead less
Reducing direct greenhouse gas emissions from urban wastewater systems. This project aims to develop a systematic framework for water utilities to monitor and reduce direct greenhouse gas (GHG) emissions from wastewater systems. A standardised monitoring protocol will be developed to conduct an unprecedented nationwide sampling campaign. The obtained data, with microbial characterisation and mechanism analysis, will be used to develop novel models for accurate prediction of GHG emissions. Expect ....Reducing direct greenhouse gas emissions from urban wastewater systems. This project aims to develop a systematic framework for water utilities to monitor and reduce direct greenhouse gas (GHG) emissions from wastewater systems. A standardised monitoring protocol will be developed to conduct an unprecedented nationwide sampling campaign. The obtained data, with microbial characterisation and mechanism analysis, will be used to develop novel models for accurate prediction of GHG emissions. Expected outcomes include protocol to accurately monitor emissions, models to predict emission under various conditions, and mitigation guideline for typical plant configurations. The anticipated benefit is a significant reduction in GHG emissions from urban water industry and support it to meet net-zero-emission goal by 2050.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100422
Funder
Australian Research Council
Funding Amount
$386,637.00
Summary
Feasible quantification of greenhouse gas emitted from wastewater treatment. This project aims to develop an accurate and practical approach to quantify greenhouse gas (GHG) emissions from wastewater treatment. Australian water utilities have pledged to net-zero emissions. However, most utilities do not know its actual emissions due to lack of feasible quantification method. This project will apply an interdisciplinary approach via mechanism investigations, mathematical modelling, and field work ....Feasible quantification of greenhouse gas emitted from wastewater treatment. This project aims to develop an accurate and practical approach to quantify greenhouse gas (GHG) emissions from wastewater treatment. Australian water utilities have pledged to net-zero emissions. However, most utilities do not know its actual emissions due to lack of feasible quantification method. This project will apply an interdisciplinary approach via mechanism investigations, mathematical modelling, and field works to develop and validate a new feasible quantification method. This project will also advance knowledge on GHG emissions to guide quantification design. The outcomes will be translated into industry protocols and disseminated into industry. The outcomes provide timely support to water sector on its pathway to net-zero.Read moreRead less
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
Design and Fabrication of 2D Hybrid Materials. There are >300 2D materials like graphene with potentially exotic and useful electrooptic and superconductor properties that will drive novel industrial applications. This project aims to use advanced computational and experimental techniques to discover and fabricate new 2D hybrid materials built from different layers of 2D materials. This approach is essential as the number of possible hybrids is huge (millions) and current processes to identify a ....Design and Fabrication of 2D Hybrid Materials. There are >300 2D materials like graphene with potentially exotic and useful electrooptic and superconductor properties that will drive novel industrial applications. This project aims to use advanced computational and experimental techniques to discover and fabricate new 2D hybrid materials built from different layers of 2D materials. This approach is essential as the number of possible hybrids is huge (millions) and current processes to identify and build 2D hybrids are technically challenging and slow. Expected outcomes include defining a new paradigm for efficient identification and synthesis of 2D hybrids with exotic, bespoke properties. The generation of a large database of materials for researchers/industry would be of wide benefit.Read moreRead less