Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
FINANCIAL (IN)SECURITY IN LATER LIFE: WOMEN, WORK , SUPERANNUATION AND AUSTRALIA'S RETIREMENT INCOME SYSTEM. An ageing population is expected to contribute to significant demographic, social and labour market shifts, which, together with fiscal stresses, will affect the future mix of state and private retirement income provisions. However, gender-based issues associated with these changes remain under-researched. Using a life-course approach qualitative methodologies will be used to explore inte ....FINANCIAL (IN)SECURITY IN LATER LIFE: WOMEN, WORK , SUPERANNUATION AND AUSTRALIA'S RETIREMENT INCOME SYSTEM. An ageing population is expected to contribute to significant demographic, social and labour market shifts, which, together with fiscal stresses, will affect the future mix of state and private retirement income provisions. However, gender-based issues associated with these changes remain under-researched. Using a life-course approach qualitative methodologies will be used to explore inter-relationships between: women's workforce participation, education, marital status, fertility, financial literacy; retirement incomes;concessions, benefits; and women's economic security in later years. The research will make a significant contribution to the development and implementation of retirement income policy and the debate on gender equity in the labour market. Read moreRead less
Testing Novel Therapies Using Paediatric Brain Tumour Models
Funder
National Health and Medical Research Council
Funding Amount
$384,023.00
Summary
Brain tumours are the second most common childhood cancer, with 300 children affected in Australia each year. Many children with brain tumours continue to die of their disease, whilst survivors are often left with devastating life long side effects. Our goals are to harness the power of innovative model systems of childhood brain tumours, in order to test the effectiveness of new treatments for these devastating diseases, so that the most promising therapies can be taken through to the clinic.
Theoretically-motivated Long-term Internet Network Adoption Based on Short Time-series: Understanding the Diffusion of an Enabling Network Technology. A recent Government policy concerns innovation as a driver of long-term industry growth and a major determinant of global competitiveness. In particular, the Internet is a ?backbone? infrastructure for the conduct e-commerce, and enables efficiency benefits and product innovations to be realized in other sectors, e.g., banking, finance, health and ....Theoretically-motivated Long-term Internet Network Adoption Based on Short Time-series: Understanding the Diffusion of an Enabling Network Technology. A recent Government policy concerns innovation as a driver of long-term industry growth and a major determinant of global competitiveness. In particular, the Internet is a ?backbone? infrastructure for the conduct e-commerce, and enables efficiency benefits and product innovations to be realized in other sectors, e.g., banking, finance, health and tourism. This study estimates the network effect critical to forecasting Internet growth. Moreover, a structural model enhances understanding of underlying Internet dynamics and impacts on general economic conditions. Importantly, methods developed here apply to any network industry, and many non-network industries characterised by strong complementarity relations.Read moreRead less
Economic Growth and Real Exchange Rates. Exchange rate movements are important elements of Australia's economic environment. Protectionist interests in the US and Europe, constrained by WTO trade rules, accuse East Asian economies of deliberate undervaluation. While exchange rate movements are not readily predictable in the short run, long run changes in underlying real exchange rates are amenable to economic analysis using structural models. The clearer understanding of these forces, toward ....Economic Growth and Real Exchange Rates. Exchange rate movements are important elements of Australia's economic environment. Protectionist interests in the US and Europe, constrained by WTO trade rules, accuse East Asian economies of deliberate undervaluation. While exchange rate movements are not readily predictable in the short run, long run changes in underlying real exchange rates are amenable to economic analysis using structural models. The clearer understanding of these forces, toward which this project is directed, will better guide investment in the region, including in Australia, and more importantly, it will better inform future policy debates surrounding currency movements.Read moreRead less
The Future of Australian Mineral Exports. Australia is among the world's largest exporters of steelmaking raw materials, specifically iron ore, coking coal and manganese. This project will develop an integrated econometric model of the global steel industry to forecast future trends in global steel production and the associated demand for raw materials. The results of this research will not only assist Australian mineral exporters in achieving better outcomes in annual pricing negotiations by im ....The Future of Australian Mineral Exports. Australia is among the world's largest exporters of steelmaking raw materials, specifically iron ore, coking coal and manganese. This project will develop an integrated econometric model of the global steel industry to forecast future trends in global steel production and the associated demand for raw materials. The results of this research will not only assist Australian mineral exporters in achieving better outcomes in annual pricing negotiations by improving market knowledge, but also help focus their longer term marketing strategies. The extensive global mine database to be assembled as part of the network flow component of this model will also allow Australian mineral exporters to assess their competitive position relative to foreign producers.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100133
Funder
Australian Research Council
Funding Amount
$2,917,436.00
Summary
How the Earth works - toward building a new tectonic paradigm. How the Earth works - toward building a new tectonic paradigm: This fellowship project aims to build on the latest technological and conceptual advances to establish the patterns of Earth evolution, and use this information to examine a ground-breaking geodynamic hypothesis which links cyclic plate aggregation and dispersion to deep Earth processes. Half a century after the inception of plate tectonics theory, we are still unsure how ....How the Earth works - toward building a new tectonic paradigm. How the Earth works - toward building a new tectonic paradigm: This fellowship project aims to build on the latest technological and conceptual advances to establish the patterns of Earth evolution, and use this information to examine a ground-breaking geodynamic hypothesis which links cyclic plate aggregation and dispersion to deep Earth processes. Half a century after the inception of plate tectonics theory, we are still unsure how the Earth 'engine' works, particularly the forces that drive plate tectonics. The project involves extensive national and international collaboration to potentially create a paradigm shift in our understanding of global tectonics, and hopes to contribute to an understanding of the formation and distribution of Earth resources to provide a conceptual framework for their exploration.Read moreRead less
The Social Production of Science in Antarctica: A Study of Davis Station. Antarctica is a unique scientific laboratory. It is the only continent historically uninhabited by humans; access to its vast land and ice-scapes, and its surrounding oceans, is today almost exclusively reserved for scientists. Although these 'Antarcticans' represent multiple disciplines, and pursue a wide variety of research agendas, their shared experiences of working on the continent, and their shared professional netwo ....The Social Production of Science in Antarctica: A Study of Davis Station. Antarctica is a unique scientific laboratory. It is the only continent historically uninhabited by humans; access to its vast land and ice-scapes, and its surrounding oceans, is today almost exclusively reserved for scientists. Although these 'Antarcticans' represent multiple disciplines, and pursue a wide variety of research agendas, their shared experiences of working on the continent, and their shared professional networks, mean that they constitute a distinct community of practice. However, this community has yet to be subjected to detailed ethnographic enquiry. This project aims to examine Antarctic scientists' research practices, and their cultures of knowledge production, through an ethnographic study of Australia's Davis Station.Read moreRead less
Analysing global consumption patterns with a large number of commodities. This project provides estimates of the income and price sensitivities of consumption, for a large number of finely distinguished goods, across most countries. These, together with new ways of enhancing economic data (by recognising quality improvements of goods and uncertainty), will be of value to researchers, government and business.