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Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Electronic skin nanopatches for continuous blood pressure monitoring. Electronic skin nanopatches for continuous blood pressure monitoring. This project aims to develop soft, thin, wearable and non-invasive heart health monitors that continuously monitor blood pressures anytime anywhere, using an electronic skin technology platform with the world’s thinnest gold nanowires. Nanotechnologists, electrical engineers, clinicians, information technologists and industrial designers will collaborate to ....Electronic skin nanopatches for continuous blood pressure monitoring. Electronic skin nanopatches for continuous blood pressure monitoring. This project aims to develop soft, thin, wearable and non-invasive heart health monitors that continuously monitor blood pressures anytime anywhere, using an electronic skin technology platform with the world’s thinnest gold nanowires. Nanotechnologists, electrical engineers, clinicians, information technologists and industrial designers will collaborate to develop blood pressure correlation algorithms and evaluate sensing performances. New knowledge and commercial technologies will make Australian medical technology industries competitive global leaders in wearable technology industries.Read moreRead less
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Enhanced brain and muscle signal separation verified by electrical scalp recordings from paralysed awake humans. This project will develop algorithms to separate brain signals from muscle signals in electrical recordings from the scalp. Cleaner brain signal measurement enables improvements in understanding how the brain works, the diagnosis and management of neurological diseases, and the development of brain-controlled devices for very disabled people.
A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less
Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres ....Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres in the brain, to collect and reconstruct images. The project is expected to reduce dMRI scan times and ultimately make non-invasive and inexpensive early detection of neurological disorders such as dementia feasible.Read moreRead less
A universally efficient antibacterial coating with remarkable durability. To prevent the spread of diseases and infections through contaminated surfaces, the project intends to create new ceramic-based coatings that combine mechanical durability with broad-spectrum antibacterial activities. Around 200 000 infections, many fatal, occur in Australian hospitals each year, with contaminated surfaces being a primary source. To combat this challenge, the project aims to develop a new class of ceramic- ....A universally efficient antibacterial coating with remarkable durability. To prevent the spread of diseases and infections through contaminated surfaces, the project intends to create new ceramic-based coatings that combine mechanical durability with broad-spectrum antibacterial activities. Around 200 000 infections, many fatal, occur in Australian hospitals each year, with contaminated surfaces being a primary source. To combat this challenge, the project aims to develop a new class of ceramic-based coatings, which are extremely robust yet highly effective in eliminating common and emerging bacteria, by uniting new antibacterial agents into a self-toughening micro-architecture. By disrupting bacterial transmission through surfaces, this project promises to protect the wellbeing of patients and healthcare professionals, and to help maintain food and water safety standards in Australia.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Dual-band antennas with digitally steerable beams made out of multi-state electromagnetic elements. A collection of antennas required for forthcoming wireless systems will be designed, made and tested. They are ideal for wireless on-body medical devices and wireless transmission of high-quality video and high-speed data. These systems will bring great benefits to wireless users and patients, including better quality of life and convenience.