Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239650
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Advanced instrumentation for nano-scale imaging and analysis. It is widely accepted that the emerging fields of Nanotechnology and Nanoengineering will dominate research activity in a wide range of disciplines over the next decade. Progress in nanoscience and technology requires parallel development in nanocharacterisation and nanofabrication techniques. This proposal seeks to enhance the level of research infrastructure support for nano-scale microscopy and microanalysis at UTS and the Univer ....Advanced instrumentation for nano-scale imaging and analysis. It is widely accepted that the emerging fields of Nanotechnology and Nanoengineering will dominate research activity in a wide range of disciplines over the next decade. Progress in nanoscience and technology requires parallel development in nanocharacterisation and nanofabrication techniques. This proposal seeks to enhance the level of research infrastructure support for nano-scale microscopy and microanalysis at UTS and the University of Sydney by providing the following advanced instrumentation for nano-scale imaging, analysis and manipulation of materials:
- A Schottky field emission gun environmental scanning electron microscope
- Equipment kit for the rapid preparation of high quality transmission electron microscope specimens.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453973
Funder
Australian Research Council
Funding Amount
$696,093.00
Summary
Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. The ....Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. These items will be incorporated into the SA Regional Facility, which provides seamless access to instrumentation across nodes. Applications include materials science, geological and biological research projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560657
Funder
Australian Research Council
Funding Amount
$740,000.00
Summary
Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology. The ultra-high resolution imaging NMR spectrometer at the centre of this application is a generation ahead of comparable facilities in Australia and will extend the research capacity of numerous research groups comprising in excess of 50 academics and postgraduate students. The aims and significance of this infrastructure lie in it being one of the centrepieces of the partner institutions' aspirations to tak ....Ultra-High Resolution NMR Imaging System for Nanotechnology including Nanobiotechnology. The ultra-high resolution imaging NMR spectrometer at the centre of this application is a generation ahead of comparable facilities in Australia and will extend the research capacity of numerous research groups comprising in excess of 50 academics and postgraduate students. The aims and significance of this infrastructure lie in it being one of the centrepieces of the partner institutions' aspirations to take Australia to the cutting edge of nanotechnology and cognate disciplines many of which are areas of national priority. The expected manifold outcomes include research of the highest rank into fundamental problems of drug development through to applied outcomes such as new nanomaterials and improved horticulture/fruit preservation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775679
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Advanced Microscopy Infrastructure for use in Frontier Technologies. This proposal seeks to establish key microscopy facilities to support the research projects from leading researchers from four major Universities. The new facilities build on the close collaborative links between the partner organisations and the request is for specialised equipment that is complementary to that available at, for example, the Australian Synchrotron. The new facilities will enhance progress in the the important ....Advanced Microscopy Infrastructure for use in Frontier Technologies. This proposal seeks to establish key microscopy facilities to support the research projects from leading researchers from four major Universities. The new facilities build on the close collaborative links between the partner organisations and the request is for specialised equipment that is complementary to that available at, for example, the Australian Synchrotron. The new facilities will enhance progress in the the important areas of nanotechnology, biotechnology and advanced materials to the benefit of the community and will play a crucial role in training the next generation of researchers to drive these critical areas of science and technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560722
Funder
Australian Research Council
Funding Amount
$512,744.00
Summary
High-speed Ultracentrifuge Facility with Sensitive Scanning Optics for the Analysis of Interacting Biomolecules. This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning optics. The equipment, the first of its kind in Australia, would establish a world-class facility for analysing the size, shape, and stability of macromolecular complexes and their interactions in solution. This new facility will enable high through ....High-speed Ultracentrifuge Facility with Sensitive Scanning Optics for the Analysis of Interacting Biomolecules. This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning optics. The equipment, the first of its kind in Australia, would establish a world-class facility for analysing the size, shape, and stability of macromolecular complexes and their interactions in solution. This new facility will enable high through-put screening of small molecules with potential as new drugs. This core platform technology will cover the range of needs from basic research through to commercialization of discovery. The equipment will support existing high quality research projects in biotechnology and provide new opportunities for post-graduate training and international collaboration.Read moreRead less
Nanoengineered Colloids and thin films through self-assembly with potential applications in Bioscince and Nanotechnology. The proposed research program will focus on the preparation, characterisation and application of novel, small (nanometer size) particles and thin (micrometer thick)films derived from such particles. These new and advanced materials will be prepared by usinf a recently developed, highly versatile and facile technology to coat particles in solution. The strategy to be used en ....Nanoengineered Colloids and thin films through self-assembly with potential applications in Bioscince and Nanotechnology. The proposed research program will focus on the preparation, characterisation and application of novel, small (nanometer size) particles and thin (micrometer thick)films derived from such particles. These new and advanced materials will be prepared by usinf a recently developed, highly versatile and facile technology to coat particles in solution. The strategy to be used entails the step-by-step construction of well-defined layers of different composition on particles and flat surfaces, thereby allowing unprecendented control over the material properties and function. This will provide new avenues for the application of nanoscale materials in biotechnology and nanotechnology.Read moreRead less
Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The ....Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.Read moreRead less
Exploiting the self-assembly of hydrophobin proteins to engineer functional nanostructuring surfaces. There is an increasing world-wide demand for advanced nano-biomaterials with novel properties. We will use natural hydrophobin proteins to coat nanodevices and make them more compatible with biological systems. Hydrophobin coatings will be applicable to biosensors, medical devices, diagnostics and drug delivery systems. The research will lead to an understanding of the basic mechanisms of protei ....Exploiting the self-assembly of hydrophobin proteins to engineer functional nanostructuring surfaces. There is an increasing world-wide demand for advanced nano-biomaterials with novel properties. We will use natural hydrophobin proteins to coat nanodevices and make them more compatible with biological systems. Hydrophobin coatings will be applicable to biosensors, medical devices, diagnostics and drug delivery systems. The research will lead to an understanding of the basic mechanisms of protein self-assembly and will have application outcomes that contribute to Australia being an important player in the field of nanotechnology. This is critical for Australia's long term competitiveness and productivity in and beyond the 21st century.Read moreRead less
Optimised distributed stimulation of muscle. The project aims to extend to humans, a method of producing a non-fatiguing, smooth, submaximal muscle contraction. The method using multiple electrodes, stimulated at different times, with those times being adjusted for optimum smoothness at low stimulation rates. This will enable the gathering of information about the mechanics of muscle undergoing near physiological contractions, which will be of interest to researchers in Biomechanics. It will ....Optimised distributed stimulation of muscle. The project aims to extend to humans, a method of producing a non-fatiguing, smooth, submaximal muscle contraction. The method using multiple electrodes, stimulated at different times, with those times being adjusted for optimum smoothness at low stimulation rates. This will enable the gathering of information about the mechanics of muscle undergoing near physiological contractions, which will be of interest to researchers in Biomechanics. It will also be a step towards the restoration of function to spinal cord injured patients.Read moreRead less
DNA Dynamics is Shear and Extensional Flows: Simulation and Single Molecule Experiments. The proposal seeks to establish a collaboration between Monash University and Stanford University in order to combine several recent experimental and theoretical advances that have been made by the individual groups in single molecule experimental techniques, extensional rheometry, and molecular rheology, to obtain new insights into the structure and dynamics of biopolymers. The central aim is to make a sign ....DNA Dynamics is Shear and Extensional Flows: Simulation and Single Molecule Experiments. The proposal seeks to establish a collaboration between Monash University and Stanford University in order to combine several recent experimental and theoretical advances that have been made by the individual groups in single molecule experimental techniques, extensional rheometry, and molecular rheology, to obtain new insights into the structure and dynamics of biopolymers. The central aim is to make a significant contribution towards bringing state-of-the-art techniques used for the characterization of polymeric systems to bear on the nature and origin of the elastic properties of biopolymers.Read moreRead less