Element Labeling Antibodies For Bio-imaging Of Proteins: A Case Study Of Beta-amyloid In Alzheimer's Disease Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$221,136.00
Summary
This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relation ....This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relationship between amyloid proteins and metal ions.Read moreRead less
Chemical Aided Phospoproteome Sequencing With Mass Spectrometry
Funder
National Health and Medical Research Council
Funding Amount
$141,000.00
Summary
Essentially all of the body's functions from muscle contraction, energy expenditure through to appetite are controlled by a complex molecular communications system. One of the key elements involves the modification of proteins to alter their properties by adding and removing phosphate. By analysing this process in response to diet and exercise we will obtain a greater understanding of their health benefits and understand how type 2 diabetes and obesity develop at the molecular level.
Development And Application Of A Novel Ultrasensitive LC-MS Estradiol Assay
Funder
National Health and Medical Research Council
Funding Amount
$240,400.00
Summary
This project will develop a new ultrasensitive method using liquid chromatography-mass spectrometry to measure extremely low level of circulating estrogens in the bloodstream especially in mice. This will allow for the first time the ability to study the natural regulation of fertility in mice and other sub-primate mammals for which the present assay methods are not adequate.
The Identification Of Novel Diagnostics And Therapeutics From Bacterial Viruses Specific For The Foodborne Pathogen Campylobacter Jejuni Using Mass Spectrometry.
Funder
National Health and Medical Research Council
Funding Amount
$313,788.00
Summary
Campylobacter jejuni is the leading cause of foodborne illness within Australia. To improve food safety there is a critical need for new therapeutics and diagnostics that target this agent. Within nature bacterial viruses possess proteins that can perform such a task. By using mass spectrometric analysis we aim to exploit billions of years of co-evolution to identify bacterial viral proteins that bind C. jejuni to identify novel means to limit and lower C. jejuni numbers in food sources.
Development Of Small Molecule Isoform-Selective Dynamin Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
Dynamin has roles in nerve cell communication and in cell division. There are 3 dynamin genes: dynamin I in brain; dynamin II in all cells; and dynamin III in brain and testes. Determination of potential selectivity of small molecule dynamin inhibitors for each dynamin gene can provide a basis for the development of new antiepileptic drugs which are specific for dynamin I and thus neuronal tissues, as well as new anticancer drugs that target dynamin II in nonneuronal cells.