Elucidating Metabolic Dysregulation In Alzheimer’s Disease: Profiling The Peripheral Immune Cell Lipidome To Unravel Pathological Mechanisms.
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Both the immune system and lipid metabolism have been identified to be important in Alzheimer’s disease (AD). With the failures of all clinical trials attempting to treat AD, we seek to determine a way to both better diagnose individuals with AD and to identify people at increased risk. This project uses a novel profiling technique to characterise the lipid composition of immune cells to diagnose, predict risk, monitor the disease and to identify potential disease modifying therapeutic targets.
Engineered interlayers of bio-retardant and nano-reinforcement on polymers. This project will address the important need for a highly effective lightweight coating. Different interlayers of bio-retardants derive from organic compounds and two-dimensional sheet-like nanomaterials are fabricated to enhance the charring, thermal barrier and flammability resistance. Molecular dynamics are adopted to deliver more targeted fabrication to achieve increased efficacy of the engineered interlayers and pro ....Engineered interlayers of bio-retardant and nano-reinforcement on polymers. This project will address the important need for a highly effective lightweight coating. Different interlayers of bio-retardants derive from organic compounds and two-dimensional sheet-like nanomaterials are fabricated to enhance the charring, thermal barrier and flammability resistance. Molecular dynamics are adopted to deliver more targeted fabrication to achieve increased efficacy of the engineered interlayers and provide important insights on the combustibility of polymers undergoing mass diffusivity, thermal diffusion and oxidation process at high temperatures. Expected outcomes of the project are lightweight coated polymers possessing elevated resistance to fire with a significant reduction of toxic gas emissions and smoke releases. Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100032
Funder
Australian Research Council
Funding Amount
$4,272,072.00
Summary
ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flamma ....ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flammability tests for compliance with fire safety regulatory standards. An expected outcome of this Training Centre is to accelerate the transformation of Australia’s industries in fire retardant materials, products and engineering services.Read moreRead less
Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans ....Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans to address the challenge of sodium stability in highly irradiated tubes by investigating mass, momentum, energy and radiative transport in liquid metals. It is intended that this will inform the design and testing of novel sodium boilers to provide stable and isothermal process heat for continuous or on-demand production of power, chemical fuels and commodities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101747
Funder
Australian Research Council
Funding Amount
$354,216.00
Summary
Mechanism and control of water droplets from condensation to defrosting. The deposition of frost/ice is inevitable and negatively impacts many fields and industries, such as the frosting of air source heat pumps and liquid natural gas vaporizers, and icing of aircraft and power cables. On the other hand, ice slurry is widely deployed for cold storage and transportation of food and organs. To accurately predict and control the frosting/icing process, this project aims to study and understand the ....Mechanism and control of water droplets from condensation to defrosting. The deposition of frost/ice is inevitable and negatively impacts many fields and industries, such as the frosting of air source heat pumps and liquid natural gas vaporizers, and icing of aircraft and power cables. On the other hand, ice slurry is widely deployed for cold storage and transportation of food and organs. To accurately predict and control the frosting/icing process, this project aims to study and understand the interrelated heat, mass and momentum transport phenomena of water droplets from condensation to defrosting. Outcomes of this project should contribute to the development of new material, such as applicable anti-icing/anti-frosting surfaces, and relative technology and equipment, and thus benefit a number of fields.Read moreRead less
3D Hypersonic Shock-Turbulent-Boundary-Layer Interactions. Shock-wave turbulent-boundary-layer interactions occur on hypersonic flight vehicles and can lead to high heating and increased drag. This is a paramount design issue that needs addressing. We aim to understand and quantify fundamental phenomena occurring in such interactions using state-of-the-art instrumentation and wind-tunnel facilities. Surfaces will be heated to realistic flight temperatures to simulate accurately the flight enviro ....3D Hypersonic Shock-Turbulent-Boundary-Layer Interactions. Shock-wave turbulent-boundary-layer interactions occur on hypersonic flight vehicles and can lead to high heating and increased drag. This is a paramount design issue that needs addressing. We aim to understand and quantify fundamental phenomena occurring in such interactions using state-of-the-art instrumentation and wind-tunnel facilities. Surfaces will be heated to realistic flight temperatures to simulate accurately the flight environment and include effects not reproduced with cold models. The effects of 3D features of the interactions will lead to new understanding of how the flow develops through a combination of experiments and numerical simulations. Future designs of hypersonic flight vehicles will benefit from knowledge gained.Read moreRead less
Thermal transport by design for fast and efficient solar thermochemical fuel production. This project aims to demonstrate the utility of the thermal transport by design approach to develop functionally graded reactive materials that allow for fast and efficient solar thermo-chemical fuel production. Prediction capabilities will be developed to optimise multi-scale radiative and gas transport coupled with non-stoichiometric redox reactions. Synthesis gas production will be demonstrated using the ....Thermal transport by design for fast and efficient solar thermochemical fuel production. This project aims to demonstrate the utility of the thermal transport by design approach to develop functionally graded reactive materials that allow for fast and efficient solar thermo-chemical fuel production. Prediction capabilities will be developed to optimise multi-scale radiative and gas transport coupled with non-stoichiometric redox reactions. Synthesis gas production will be demonstrated using the new structures in a prototype solar thermochemical reactor under high-flux irradiation. This project aims to advance the fields of thermal sciences and high-temperature solar thermochemical processing and expand the engineering knowledge base to pave the way to sustainable transportation with the existing infrastructure.Read moreRead less
Scaling laws for aerodynamics of moving wings in the Martian atmosphere. This project aims to increase understanding of the aerodynamics of bio-inspired flight in the low-density atmosphere of Mars. The significance of flight in planetary exploration is shown by the ongoing success of the Ingenuity helicopter on Mars, and the Dragonfly rotorcraft planned for use on Titan. Expected outcomes of this project will be innovative numerical modelling techniques validated using local specially designed ....Scaling laws for aerodynamics of moving wings in the Martian atmosphere. This project aims to increase understanding of the aerodynamics of bio-inspired flight in the low-density atmosphere of Mars. The significance of flight in planetary exploration is shown by the ongoing success of the Ingenuity helicopter on Mars, and the Dragonfly rotorcraft planned for use on Titan. Expected outcomes of this project will be innovative numerical modelling techniques validated using local specially designed low-pressure experimental facilities. Benefits will be more accurate design guidance for efficient and robust flapping and rotary wing robotic vehicles for Mars and other space exploration that take advantage of the unique atmospheric conditions, and in placing Australia at the forefront of such design technology.Read moreRead less
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less
Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxyge ....Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxygen enrichment can augment scramjet thrust at high altitudes and speeds, and a performance evaluation of a launch system optimised for this approach. This could provide significant benefits to the performance of reusable, air-breathing launch technology, where Australia is leading the push towards commercialisation.Read moreRead less