Development And Application Of A Novel Ultrasensitive LC-MS Estradiol Assay
Funder
National Health and Medical Research Council
Funding Amount
$240,400.00
Summary
This project will develop a new ultrasensitive method using liquid chromatography-mass spectrometry to measure extremely low level of circulating estrogens in the bloodstream especially in mice. This will allow for the first time the ability to study the natural regulation of fertility in mice and other sub-primate mammals for which the present assay methods are not adequate.
How Burkholderia Pseudomallei Subverts Host Ubiquitination And Autophagy Pathways
Funder
National Health and Medical Research Council
Funding Amount
$472,260.00
Summary
Burkholderia pseudomallei is a bacterial organism found in soil and water that is the causative agent of melioidosis, a serious invasive disease of humans and animals occurring in tropical areas including northern Australia. Mortality is high owing to only limited treatment options being available. By defining the molecular mechanisms how B. pseudomallei evades removal from infected cells, we aim to identify specific bacterial targets that may form the basis of future prevention strategies.
Skeletal Muscle Signal Transduction Related To Exercise, Metabolic Disease And Human Health
Funder
National Health and Medical Research Council
Funding Amount
$557,298.00
Summary
Exercise is one of the best prevention and treatment strategies for all major human diseases. Despite these well documented advantages, we still do not know exactly how exercise produces these benefits at the molecular level. A comprehensive understanding of this will lead to new avenues to treat many diseases. This project will monitor thousands of molecular changes that occur in human muscle biopsies following exercise and create the world’s first molecular blueprint of exercise.
Trends And Determinants Of Blood Pressure In Chinese Children And Adolescents During The Recent Obesity Epidemic: A Repeated Cross-sectional Study Over 25 Years
Funder
National Health and Medical Research Council
Funding Amount
$349,259.00
Summary
Over the last 25 years, the prevalence of overweight and obesity increased over 9 times among Chinese children and adolescents. The aims of this project are to assess the trends of blood pressure levels in children during the period of obesity epidemic, and to estimate the effects of obesity and other factors on the trends of blood pressure levels. In this repeated cross-sectional study, we will analyse the data of six surveys collected over a period of 25 years with over 1.4 million participant ....Over the last 25 years, the prevalence of overweight and obesity increased over 9 times among Chinese children and adolescents. The aims of this project are to assess the trends of blood pressure levels in children during the period of obesity epidemic, and to estimate the effects of obesity and other factors on the trends of blood pressure levels. In this repeated cross-sectional study, we will analyse the data of six surveys collected over a period of 25 years with over 1.4 million participants.Read moreRead less
The Role Of N-linked Protein Glycosylation In Campylobacter Jejuni Pathogenesis
Funder
National Health and Medical Research Council
Funding Amount
$757,600.00
Summary
Protein glycosylation is crucial in enabling C. jejuni to colonize poultry, which is the most common route to human infection. The roles played by this modification remain almost completely unknown yet are likely to be multi-factorial. This project will determine the function of glycosylation and thus lead to eventual interventions aimed at reducing the organism in poultry for human consumption.
Suppressor Of Cytokine Signalling (SOCS4) Is A Critical Regulator Of The Anti-viral Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$616,912.00
Summary
The SOCS proteins are negative regulators of cytokine signalling and immune cell development and function. SOCS4 is the last remaining SOCS protein for which there is no described function or intracellular target. We intend to use well-defined acute and chronic viral disease models, and investigate the role of SOCS4 in infection in order to unravel its function. We will also search for its binding partners and intracellular targets, and determine the signalling pathways regulated by SOCS4.
Understanding The Role Of O-linked Glycosylation In Burkholderia Cenocepica For Host Survival Using Proteomic Approaches
Funder
National Health and Medical Research Council
Funding Amount
$222,004.00
Summary
The bacteria Burkholderia cenocepecia (Bc) is a common infection of Cystic Fibrosis suffers in Australia. ~20% CF patients infected with Bc will die due to lung failure. Due to this high death rate there is an urgent need to understand how Bc survives and causes disease in the host. This grant aims to understand how the attachment of sugars, a process known as glycosylation, affects the ability of Bc to survive in mammalian cells.
Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Role Of RNA-binding Proteins In Cardiomyocyte Physiology
Funder
National Health and Medical Research Council
Funding Amount
$880,494.00
Summary
Interactions between ribonucleic acids and proteins are of critical importance to gene expression and may also connect it to cell metabolism in unexpected ways. We hypothesise that this is of particular importance in cardiac health and disease. We will employ the tools of proteomics and transcriptomics to characterise the topology and function of RNA-protein interaction networks in heart muscle cells, and thus contribute to the search for better treatment.
Identifying Metabolic Pathways In Leishmania Parasites And Their Host Cells Required For Virulence
Funder
National Health and Medical Research Council
Funding Amount
$989,110.00
Summary
Our lack of understanding of microbial metabolism in infected animal tissues has hindered the development of effective therapies. This is particularly true for many parasitic diseases, including Leishmania spp that cause devastating disease throughout the tropics. We will utilize a range of innovative analytical and genetic approaches to identify metabolic pathway in Leishmania parasites and infected host cells that are required for virulence and are potential drug targets.