Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could l ....Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could lead to improved disease management and eradication programs through identification and treatment of drug resistant pathogens in individuals that have the potential to re-infect the community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100213
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Advanced fluorescence characterisation facility. Fluorescence is the emission of light by a substance that has absorbed light of a different wavelength. Fluorescence techniques and fluorescent molecules have enabled a great many of the most important advances in biology, chemistry and medicine in recent decades. This facility will support a wide range of research projects using or exploring fluorescence and luminescence. The research supported will underpin advances in diverse scientific fields.
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagn ....Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagnostics, forensic sample determination and industrial process monitoring through decreased analysis time with an increase in the chemical information gained. By performing chemical separations on a microfluidic scale a reduction in both the cost of analysis and impact of solvent waste on the environment will be achieved.Read moreRead less
Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation fr ....Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation from a single capillary and geometrically matching the bore of the tube collecting the emitted ion plume. NanoESI-MS has become an indispensable analytical tool for proteomics and synthetic chemistry. The significant enhancement of nanoESI-MS sensitivity in this project is expected to accelerate progress in disease research, biomarker discovery and drug development.Read moreRead less
Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Bet ....Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Better elemental and isotope ratio data from these high-throughput instruments will open up new real-world applications in many areas of Australian interest, such as biosecurity, forensics, groundwater management, and drug design. The research will also inform design of the next generation instruments by the industry partner.Read moreRead less