Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346903
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
LC-MS system for Faculty of Sciences, U.N.E. LC-MS is a technique for investigating the composition of complex mixtures and identifying its components. This instrumentation will be utilised at UNE in a diverse range of analytical investigations to further the research aims of scientists in chemistry, biological sciences, archaeology, physics, environmental sciences, marine science as well as biological researchers in specialised units based at UNE. The extraordinarily versatile capacity of this ....LC-MS system for Faculty of Sciences, U.N.E. LC-MS is a technique for investigating the composition of complex mixtures and identifying its components. This instrumentation will be utilised at UNE in a diverse range of analytical investigations to further the research aims of scientists in chemistry, biological sciences, archaeology, physics, environmental sciences, marine science as well as biological researchers in specialised units based at UNE. The extraordinarily versatile capacity of this technique for analysis and identification of organic substances, from small molecules through to large proteins and complex plant and animal metabolites, will provide impetus for existing research and stimulus for new research directions.Read moreRead less
Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and character ....Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and characterization. These approaches will allow the scientific community to further mine beneath the surface of the proteomics 'iceberg'.Read moreRead less
Establishing the role of alpha-2-macroglobulin in quality control of extracellular protein folding. The expected outcomes will provide important advances in understanding the role of alpha-2-macroglobulin (A2M) in maintaining the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad si ....Establishing the role of alpha-2-macroglobulin in quality control of extracellular protein folding. The expected outcomes will provide important advances in understanding the role of alpha-2-macroglobulin (A2M) in maintaining the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to world research outcomes. This project will also provide a direct social benefit by training research students with the skills necessary to further the development of biological research in Australia.Read moreRead less
Discovering Mechanisms for Quality Control of Extracellular Protein Folding. The expected outcomes will provide important advances in understanding of how the mammalian body maintains the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it w ....Discovering Mechanisms for Quality Control of Extracellular Protein Folding. The expected outcomes will provide important advances in understanding of how the mammalian body maintains the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to world research outcomes. This project will also provide a direct social benefit by training research students with the skills necessary to further the development of biological research in Australia. Read moreRead less