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Mechanisms Of Cell Death In Chronic Compressive Myelopathy Using A Rodent Model
Funder
National Health and Medical Research Council
Funding Amount
$56,765.00
Summary
This study investigates the process of cell death in the spinal cord following chronic compression using a rat model. Chronic spinal cord compression can occur in common conditions such as 'slipped disc' or disc prolapse, the increased formation of bone around the spinal cord that is more common with age, or from tumours forming around the spinal cord in cancer patients. The distribution, timing and the mechanism by which cells die in the cord after compression will be analysed.
Optimising The Bone And Cardiovascular Response To Dietary Calcium: A Physiological Approach In Experimental Models
Funder
National Health and Medical Research Council
Funding Amount
$35,670.00
Summary
We aim to identify a variable calcium diet that optimises bone mass, density and strength as well as blood pressure in a rat model of intrauterine growth restriction. We propose that a moderate calcium diet followed by a high calcium diet is beneficial for bone and heart health. This is based on the physiological effect of reduced calcium intake stimulating intestinal calcium absorption. This represents a novel research approach to improving calcium intake, bone as well as heart health.
VULNERABILITY OF THE INTRAUTERINE GROWTH RESTRICTED HEART AND KIDNEY TO ELEVATIONS IN BLOOD GLUCOSE LEVELS IN ADULTHOOD
Funder
National Health and Medical Research Council
Funding Amount
$58,288.00
Summary
It is proposed that the hearts and kidneys of subjects that were born small for gestational age are particularly vulnerable to the pathophysiological changes induced by hyperglycemia, even when blood glucose levels are only mildly elevated. In the present project, this concept will be investigated. The outcomes of this study will be particularly relevant to the Australian Aboriginal population, as they have a higher incidence than normal of low birth weight and impaired glucose metabolism.
Impact Of Fetal Growth Restriction On Skeletal Muscle Development, Mitochondrial Biogenesis And The Effect Of Exercise.
Funder
National Health and Medical Research Council
Funding Amount
$58,182.00
Summary
Being born small is associated with the development of adult diseases. Mitochondria generate energy within cells and impaired function is implicated in disease development. This project aims to define the impact of fetal growth restriction on skeletal muscle development and mitochondrial function in early life and the responsiveness to lifestyle interventions such as improved nutrition and exercise. The outcomes could provide the rationale for clinical and subsequent intervention trials.
Prognostic Markers Of Cardiovascular Risk In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$104,132.00
Summary
One in three Australians are at risk of chronic kidney disease; however, these patients are more likely to die of heart disease. There is a need to identify markers in kidney failure patients to detect heart disease early. Unmasking cardiac risk factors by using change in cardiac biomarkers and echocardiographic parameters with exercise is novel. This will help the physician to diagnose _subclinical� cardiovascular dysfunction early, hence preventing cardiovascular mortality by institution of ap ....One in three Australians are at risk of chronic kidney disease; however, these patients are more likely to die of heart disease. There is a need to identify markers in kidney failure patients to detect heart disease early. Unmasking cardiac risk factors by using change in cardiac biomarkers and echocardiographic parameters with exercise is novel. This will help the physician to diagnose _subclinical� cardiovascular dysfunction early, hence preventing cardiovascular mortality by institution of appropriate therapies.Read moreRead less